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21.发明授权COMPOUNDS AND METHODS FOR LOWERING CHOLESTEROL LEVELS WITHOUT INDUCING HYPERTRIGLYCERIDEMIA 有权化合物和方法降低胆固醇MIRROR时不感应高甘油三酯血症
公开(公告)号：EP1274717B1
公开(公告)日：2008-02-27
申请号：EP01926716.0
申请日：2001-04-06
IPC分类号： C07H21/04 , C07K14/775
CPC分类号： C07K14/775 , A61K38/00 , A61K48/00 , C12N2799/021
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22.发明公开Niacin-containing substained-release tablets and kits 失效Niacinhaltige Tabletten undSätzemitverzögerterWirkstoffabgabe
公开(公告)号：EP1688143A2
公开(公告)日：2006-08-09
申请号：EP06006409.4
申请日：1993-06-29
IPC分类号： A61K31/455 , A61K9/20 , A61K9/28
CPC分类号： A61K9/2013 , A61K9/2054 , A61K31/455 , Y10S514/824
摘要： The invention provides the use of niacin for the manufacture of a controlled release dosage form for the nocturnal treatment of hypercholesterolaemia in a single total daily dose.
摘要翻译： 本发明提供了烟酸用于制造用于单次总日剂量的夜间治疗高胆固醇血症的控释剂型的用途。
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23.发明授权TREATMENT OF STRESS-INDUCED SKIN DISEASE BY CORTICOTROPIN RELEASING HORMONE (CRH) ANTAGONISTS AND SKIN MAST CELL DEGRANULATION INHIBITORS 失效治疗压力诱导的皮肤疾病USING促肾上腺皮质激素（CRH）拮抗剂和皮肤的肥大细胞脱粒抑制剂的
公开(公告)号：EP0942749B1
公开(公告)日：2003-06-11
申请号：EP97936413.0
申请日：1997-08-06
IPC分类号： A61K39/395 , A61K38/17 , A61K38/22 , A61K31/35 , A61K31/495
CPC分类号： A61K45/06 , A61K31/352 , A61K31/495 , A61K38/2228 , A61K2300/00
摘要： A method of reducing or blocking a stress-related atopic skin disease such as exzema or urticaria in a subject comprising administering to the patient an agent that antagonizes CRH-induced activation of skin mast cells, the agent being used alone or together with a second agent that inhibits activation of skin mast cells. Such agents include compositions that reduce the production or secretion of CRH, neurotensin or somatostatin or an agent that inhibits the physiological action of CRH, neurotensin or somostatin on skin mast cells. The effects of CRH on skin mast cells can also be inhibited by histamine-3 receptor antagonists and by inhibitors of the phosphorylation of skin mast cell moesin.
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24.发明公开Compositions comprising a mast cell degranulation-blocking agent for treatment of endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin. 失效含有肥大细胞脱粒粘连剂，内源性的处理组合物，疼痛的胃肠道症状与非炎性，非溃疡性原点
公开(公告)号：EP1203586A3
公开(公告)日：2002-10-30
申请号：EP02075270.5
申请日：1995-02-09
IPC分类号： A61K31/417 , A61P1/06
CPC分类号： A61K38/09 , A61K31/00 , A61K31/13 , A61K31/135 , A61K31/35 , A61K31/415 , A61K31/417 , A61K31/445 , A61K31/495 , A61K31/55 , A61K31/565 , Y10S514/01 , A61K2300/00
摘要： A method for treating endogenous, painful gastrointestinal condition of non-inflammatory, non-ulcerative origin, such as abdominal migraine and irritable bowel syndrome, entails administering a pharmacologically effective amount of a mast cell degranulation-blocking agent, e.g. a histamine-3 receptor agonist.
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25.发明公开NICOTINIC ACID COMPOSITIONS FOR TREATING HYPERLIPIDEMIA AND RELATED METHODS THEREFOR 失效含有治疗高脂血症AND METHOD FOR应用他们烟酸组合物
公开(公告)号：EP0969837A1
公开(公告)日：2000-01-12
申请号：EP98907745.8
申请日：1998-03-06
发明人： CEFALI, Eugenio, A.
IPC分类号： A61K31/455 , A61K9/20
CPC分类号： A61K31/44 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K31/455
摘要： An orally administered antihyperlipidemia composition according to the present invention includes from about 250 to about 3000 parts by weight of nicotinic acid, and from about 5 to about 50 parts by weight of hydroxypropyl methylcellulose. Also, a method of treating hyperlipidemia in a hyperlipidemic having a substantially periodic physiological loss of consciousness includes the steps of forming a composition having an effective antihyperlipidemic amount of nicotinic acid and a time release sustaining amount of a swelling agent. The method also includes the step of orally administering the composition to the hyperlipidemic once per day 'nocturnally', that is in the evening or at night.
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26.发明公开TREATMENT OF STRESS-INDUCED SKIN DISEASE BY CORTICOTROPIN RELEASING HORMONE ANTAGONISTS AND SKIN MAST CELL DEGRANULATION INHIBITORS 失效治疗压力引起的皮肤疾病的使用促肾上腺皮质激素拮抗剂与皮肤肥大细胞脱颗粒抑制剂
公开(公告)号：EP0942749A2
公开(公告)日：1999-09-22
申请号：EP97936413.0
申请日：1997-08-06
IPC分类号： A61K38
CPC分类号： A61K45/06 , A61K31/352 , A61K31/495 , A61K38/2228 , A61K2300/00
摘要： A method of reducing or blocking a stress-related atopic skin disease such as exzema or urticaria in a subject comprising administering to the patient an agent that antagonizes CRH-induced activation of skin mast cells, the agent being used alone or together with a second agent that inhibits activation of skin mast cells. Such agents include compositions that reduce the production or secretion of CRH, neurotensin or somatostatin or an agent that inhibits the physiological action of CRH, neurotensin or somostatin on skin mast cells. The effects of CRH on skin mast cells can also be inhibited by histamine-3 receptor antagonists and by inhibitors of the phosphorylation of skin mast cell moesin.
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27.发明公开COMPOSITIONS COMPRISING A MAST CELL DEGRANULATION-BLOCKING AGENT FOR TREATMENT OF ENDOGENOUS, PAINFUL GASTROINTESTINAL CONDITIONS OF NON-INFLAMMATORY, NON-ULCERATIVE ORIGIN 失效组合物A的肥大细胞脱粒阻止活动CONTAIN内源性FUE的治疗，PAINFUL GASTROINTTESTINALEN COMPLAINTS NOT炎症，NICHTULZERATIVEN ORIGIN
公开(公告)号：EP0748217A1
公开(公告)日：1996-12-18
申请号：EP95909451.0
申请日：1995-02-09
CPC分类号： A61K38/09 , A61K31/00 , A61K31/13 , A61K31/135 , A61K31/35 , A61K31/415 , A61K31/417 , A61K31/445 , A61K31/495 , A61K31/55 , A61K31/565 , Y10S514/01 , A61K2300/00
摘要： A method for treating endogenous, painful gastrointestinal conditions of non-inflammatory, non-ulcerative origin, such as abdominal migraine and irritable bowel syndrome, entails administering a pharmacologically effective amount of a mast cell degranulation-blocking agent, e.g. a naturally occurring polyamine, a heterocyclic histamine-1 receptor antagonist, a histamine-3 receptor agonist or an anti-female sex hormone.
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