公开(公告)号：EP1513497A2

公开(公告)日：2005-03-16

申请号：EP03738984.8

申请日：2003-05-28

申请人： Alza Corporation

发明人： FINK, Tracy Ann ,  AYER, Atul D. ,  JOHNSON, Deborah J. ,  SHIVANAND, Padmaja

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61P25/04 ,  A61K31/485

CPC分类号： A61K31/485 ,  A61K9/0004

摘要： Dosage forms, compositions and methods for the controlled release of oxycodone over a prolonged period of time are described. The present invention discloses a novel means for delivering varying doses of oxycodone using a drug composition having only oxycodone, a polymer carrier and varying amounts of salt to provide a particular viscosity of the hydrated drug core for delivery of the drug at the desired release rate. The present invention functions by modulating the viscosity of the hydrated drug layer in operation by the addition or reduction of salts in the drug composition. The system is independent of solubility enhancers or pH modifiers. The sustained release dosage forms provide therapeutically effective average steady-state plasma oxycodone concentrations when administered once per day.

公开(公告)号：EP0957899A2

公开(公告)日：1999-11-24

申请号：EP97936421.0

申请日：1997-08-08

申请人： ALZA CORPORATION

发明人： SHIVANAND, Padmaja ,  AYER, Atul, D. ,  WRIGHT, Jeri, D. ,  LAM, Andrew ,  HAMEL, Lawrence, G.

IPC分类号： A61K9

CPC分类号： A61K9/0004

摘要： A bilayer and trilayer tablet and a dosage form are disclosed for administering a controlled and increasing dose of drug over time. A method is disclosed also for administering an increasing dose of drug over time.