公开(公告)号：EP0907358B1

公开(公告)日：2001-12-12

申请号：EP97916120.5

申请日：1997-03-20

申请人： ALZA CORPORATION

发明人： AYER, Atul, Devdatt ,  LAM, Andrew ,  MAGRUDER, Judy, A. ,  HAMEL, Lawrence, G. ,  WONG, Patrick, S.-L.

IPC分类号： A61K9/22 ,  A61K9/52

CPC分类号： A61K9/0004

公开(公告)号：EP0538335B1

公开(公告)日：1995-01-11

申请号：EP91912826.4

申请日：1991-07-08

申请人： ALZA CORPORATION

发明人： WONG, Patrick, S.- L. ,  JAO, Frank ,  THEEUWES, Felix ,  LAM, Andrew

IPC分类号： A61K9/22 ,  A61K9/00

CPC分类号： A61K9/0004

摘要： An osmotic device (10) is disclosed that comprises a first and second means that act together to provide a drug-free interval prior to the delivery of a drug (15) from inside the device (10). The first means slows the passage of fluid through wall (12) into device (10), and the second means in the device delays the delivery of drug (16) from device (10).

公开(公告)号：EP1677758A1

公开(公告)日：2006-07-12

申请号：EP04810119.0

申请日：2004-10-29

申请人： ALZA CORPORATION

发明人： WONG, Patrick, S., L. ,  YAN, Dong ,  LAM, Andrew ,  HWANG, Stephen ,  GUITTARD, George, V.

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K31/185 ,  A61K31/66 ,  A61P25/08

CPC分类号： A61K31/662 ,  A61K9/0004 ,  A61K31/155 ,  A61K31/185 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/20 ,  A61K31/295 ,  A61K31/66 ,  A61K33/26 ,  A61K47/541 ,  A61K47/585 ,  A61K2300/00

摘要： Disclosed are substances, compositions, dosage forms and methods relating to drugs including 3-aminopropyl-n-butyl-phosphinic acid; structural homologs thereof; 3-aminopropyl-n-butyl-phosphinic acid complexes; complexes that comprise structural homologs of 3-aminopropyl-n-butyl-phosphinic acid; pharmaceutically acceptable salts of 3-aminopropyl-n-butyl-phosphinic acid or structural homologs thereof; and mixtures of the above.

公开(公告)号：EP0957899B1

公开(公告)日：2003-03-19

申请号：EP97936421.3

申请日：1997-08-08

申请人： ALZA Corporation

发明人： SHIVANAND, Padmaja ,  AYER, Atul, D. ,  WRIGHT, Jeri, D. ,  LAM, Andrew ,  HAMEL, Lawrence, G.

IPC分类号： A61K9/00

CPC分类号： A61K9/0004

摘要： A bilayer and trilayer tablet and a dosage form are disclosed for administering a controlled and increasing dose of drug over time. A method is disclosed also for administering an increasing dose of drug over time.

公开(公告)号：EP0538335A1

公开(公告)日：1993-04-28

申请号：EP91912826.0

申请日：1991-07-08

申请人： ALZA CORPORATION

发明人： WONG, Patrick, S.- L. ,  JAO, Frank ,  THEEUWES, Felix ,  LAM, Andrew

IPC分类号： A61K ,  A61K9

CPC分类号： A61K9/0004

摘要： Dispositif osmotique (10) comportant un premier et un second éléments qui fonctionnent ensemble pour permettre un laps de temps sans décharge de médicament avant la libération d'un médicament (15) depuis l'intérieur dudit dispositif (10). Le premier élément ralentit le passage du liquide à travers la paroi (12) vers le dispositif (10) et le second élément dans le dispositif retarde la libération du médicament (16) par ledit dispositif (10).

公开(公告)号：EP0946151B1

公开(公告)日：2006-05-10

申请号：EP97947642.1

申请日：1997-11-12

申请人： ALZA CORPORATION

发明人： HAMEL, Lawrence, G. ,  AYER, Atul, Devdatt ,  WRIGHT, Jeri, D. ,  LAM, Andrew ,  SHIVANAND, Padmaja

IPC分类号： A61K9/22

CPC分类号： A61K9/0004

摘要： A dosage form and a method are disclosed for delivering to a human patient a drug in an ascending amount over time.

公开(公告)号：EP0957899A2

公开(公告)日：1999-11-24

申请号：EP97936421.0

申请日：1997-08-08

申请人： ALZA CORPORATION

发明人： SHIVANAND, Padmaja ,  AYER, Atul, D. ,  WRIGHT, Jeri, D. ,  LAM, Andrew ,  HAMEL, Lawrence, G.

IPC分类号： A61K9

CPC分类号： A61K9/0004

摘要： A bilayer and trilayer tablet and a dosage form are disclosed for administering a controlled and increasing dose of drug over time. A method is disclosed also for administering an increasing dose of drug over time.

公开(公告)号：EP0907358A2

公开(公告)日：1999-04-14

申请号：EP97916120.0

申请日：1997-03-20

申请人： ALZA CORPORATION

发明人： AYER, Atul, Devdatt ,  LAM, Andrew ,  MAGRUDER, Judy, A. ,  HAMEL, Lawrence, G. ,  WONG, Patrick, S.-L.

IPC分类号： A61K9 ,  A61K47

CPC分类号： A61K9/0004

摘要： The invention disclosed pertains to a novel delivery system comprising an agent formulation and means for dispensing the agent formulation from the delivery system.

公开(公告)号：EP1684713A1

公开(公告)日：2006-08-02

申请号：EP04819096.1

申请日：2004-11-12

申请人： ALZA CORPORATION

发明人： LI, Shaoling ,  LAM, Andrew ,  DONG, Liang

IPC分类号： A61K9/00 ,  A61K9/52 ,  A61K31/35

CPC分类号： A61K31/35 ,  A61K9/0004

摘要： This invention relates to novel formulations and methods for the controlled release delivery of topiramate; as well as to the use of these formulations and methods for treating disease.

公开(公告)号：EP1534238A1

公开(公告)日：2005-06-01

申请号：EP03771915.0

申请日：2003-07-28

申请人： ALZA Corporation

发明人： JAO, Frank ,  EDGREN, David ,  WONG, Patrick, S.L. ,  SKLUZACEK, Robert ,  LI, Shu ,  LAM, Andrew ,  AYER, Atul, D. ,  LI, Shaoling ,  TO, Winnie

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K31/35

CPC分类号： A61K31/35 ,  A61K9/0004

摘要： Dosage forms and devices for enhancing controlled delivery of lowly soluble active agents including topiramate by use of a drug core composition that increases the solubility of the pharmaceutical agent are described. The present invention provides a drug core composition for delivering high doses of lowly soluble topiramate in solid oral drug delivery systems that are convenient to swallow, for once-a-day administration. The drug core composition contains topiramate, a surfactant and a carrier in ratios for optimal solubility and delivery.