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21.发明公开9-AZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES WITH A HETEROATOM AT THE 3-POSITION AS RENIN INHIBITORS 审中-公开在3-位AS肾素抑制剂杂原子的9AZABICYCLO¬3.3.1NON-6-EE衍生物
公开(公告)号：EP1622685A1
公开(公告)日：2006-02-08
申请号：EP04729430.1
申请日：2004-04-26
发明人： BEZENCON, Oliver , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas , SIFFERLEN, Thierry
IPC分类号： A61P9/00 , A61K31/5386 , A61K31/547 , C07D513/08 , C07D498/08
CPC分类号： C07D513/08
摘要： The invention relates to novel 9-azabicyclo[3.3.1]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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公开(公告)号：EP3292127A1
公开(公告)日：2018-03-14
申请号：EP16719875.3
申请日：2016-05-03
发明人： BUR, Daniel , GRISOSTOMI, Corinna , KIMMERLIN, Thierry , REMEN, Lubos , SIENDT, Hervé , VERCAUTEREN, Magali , WELFORD, Richard
IPC分类号： C07D471/14 , A61K31/4375 , A61P11/00 , A61P35/00 , A61P1/00
CPC分类号： C07D471/14 , A61P1/00 , A61P1/04 , A61P1/08 , A61P1/10 , A61P1/16 , A61P3/10 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/12 , A61P11/00 , A61P11/06 , A61P19/10 , A61P25/00 , A61P25/06 , A61P25/20 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06
摘要： wherein R1a, R1b, R2, R3, (R4)n and ring (A) are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.
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公开(公告)号：EP1620403B1
公开(公告)日：2007-11-28
申请号：EP04729420.2
申请日：2004-04-26
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas
IPC分类号： C07D211/78 , A61K31/451
CPC分类号： C07D211/78
摘要： The invention relates to novel 3,4-disubstituted 1,2,3,6-tetrahydropyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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公开(公告)号：EP1786814A1
公开(公告)日：2007-05-23
申请号：EP05777694.0
申请日：2005-08-22
发明人： BEZENCON, Olivier , BOSS, Christoph , BUR, Daniel , CORMINBOEUF, Olivier , FISCHLI, Walter , GRISOSTOMI, Corinna , REMEN, Lubos , RICHARD, Sylvia , SIFFERLEN, Thierry , WELLER, Thomas
IPC分类号： C07D471/08 , A61K31/4995 , A61P13/12 , A61P9/12
CPC分类号： C07D471/08 , C07D513/08
摘要： The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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25.发明公开DIAZABICYCLONONENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS 审中-公开DIAZABICYCLONONENE衍生物及其作为肾素抑制剂的用途
公开(公告)号：EP1678176A1
公开(公告)日：2006-07-12
申请号：EP04790163.2
申请日：2004-10-07
发明人： BEZENCON, Olivier , SIFFERLEN, Thierry , BUR, Daniel , FISCHLI, Walter , WELLER, Thomas , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia
IPC分类号： C07D471/08 , A61K31/4995 , A61P13/12
CPC分类号： C07D471/08
摘要： The invention relates to novel derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
摘要翻译： 本发明涉及新型衍生物和相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及相关方面，包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是它们作为肾素抑制剂的用途。
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公开(公告)号：EP1622907A1
公开(公告)日：2006-02-08
申请号：EP04729428.5
申请日：2004-04-26
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas , SIFFERLEN, Thierry
IPC分类号： C07D471/08 , A61K31/4995
CPC分类号： C07D471/08
摘要： The invention relates to novel 9-azabicyclo[3.3.1 ]nonene derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
摘要翻译： 本发明涉及新的9-氮杂二环[3.3.1]壬烯衍生物和相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及相关方面，包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是它们作为肾素抑制剂的用途。
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27.发明公开7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES 有权7-芳基 - 3,9-二氮杂双环[3.3.1]壬-6-烯衍生物及其AS肾素抑制剂用于治疗高血压的治疗，心血管疾病和肾病
公开(公告)号：EP1501830A1
公开(公告)日：2005-02-02
申请号：EP03727287.9
申请日：2003-04-08
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WEBER, Hans-Peter , WELLER, Thomas
IPC分类号： C07D471/08 , A61K31/4995
CPC分类号： C07D471/08 , A61K31/4995 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.
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