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公开(公告)号：EP1948639A2
公开(公告)日：2008-07-30
申请号：EP06829926.2
申请日：2006-11-01
发明人： BOEHRINGER, Markus , GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , PANDAY, Narendra , RICKLIN, Fabienne , STAHL, Martin , SCHMITZ, Petra
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention is concerned with novel carbocyclyl fused cyclic amines of formula (I) wherein A, X1 to X3, Y1 to Y3, Z, R1, R2, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
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公开(公告)号：EP2964646B1
公开(公告)日：2017-04-19
申请号：EP14709590.5
申请日：2014-03-04
发明人： GRETHER, Uwe , KIMBARA, Atsushi , NETTEKOVEN, Matthias , RICKLIN, Fabienne , ROEVER, Stephan , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja
IPC分类号： C07D471/04 , C07D487/04 , C07D473/04
CPC分类号： A61K31/519 , C07D471/04 , C07D473/04 , C07D487/04
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公开(公告)号：EP2182953A2
公开(公告)日：2010-05-12
申请号：EP08775169.9
申请日：2008-07-17
发明人： AEBI, Johannes , BINGGELI, Alfred , GREEN, Luke , HARTMANN, Guido , MAERKI, Hans P. , MATTEI, Patrizio , RICKLIN, Fabienne , ROCHE, Olivier
IPC分类号： A61K31/538 , A61K31/4747 , C07D231/14 , C07D401/04 , C07D403/06
CPC分类号： C07D231/14 , C07D401/04 , C07D403/06
摘要： The invention is concerned with novel pyrazol derivatives of formula (I), wherein formula (II), R1, R2, R3, R4, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor and/or CCR-5 receptor and can be used as medicaments.
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公开(公告)号：EP2076511A1
公开(公告)日：2009-07-08
申请号：EP07821295.8
申请日：2007-10-15
发明人： GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , HILPERT, Hans , KUHN, Bernd , PANDAY, Narendra , RICKLIN, Fabienne
IPC分类号： C07D413/14 , A61K31/497 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention is concerned with novel heteroaryl carboxamides of formula (I), wherein A, R1, R2, X, Y, Z and m are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
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公开(公告)号：EP2029601A1
公开(公告)日：2009-03-04
申请号：EP07729022.9
申请日：2007-05-11
发明人： CONTE, Aurelia , DEHMLOW, Henrietta , GRETHER, Uwe , KRATOCHWIL, Nicole A. , KUEHNE, Holger , NARQUIZIAN, Robert , PANOUSIS, Constantinos , PETERS, Jens-Uwe , RICKLIN, Fabienne , ROEVER, Stephan
IPC分类号： C07D487/04 , A61K31/519 , A61P3/06
CPC分类号： C07D471/04
摘要： The invention is concerned with novel pyridopyrimidinone derivatives of formula (I), wherein R1 to R8, X, Y, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型吡啶并嘧啶酮衍生物，其中R 1至R 8，X，Y，m和n如说明书和权利要求中所定义，以及其生理上可接受的盐和酯。 这些化合物是HM74A激动剂，可以用作药物。
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公开(公告)号：EP2010506A1
公开(公告)日：2009-01-07
申请号：EP07727958.6
申请日：2007-04-11
发明人： AEBI, Johannes , GREEN, Luke , MATTEI, Patrizio , RICKLIN, Fabienne , ROCHE, Olivier , ZAHM, Peter
IPC分类号： C07D243/14 , C07D405/12 , C07D401/06 , C07D401/14 , C07D401/12 , C07D403/06 , C07D471/10 , A61K31/551 , C07D403/12 , C07D405/06 , C07D413/12
CPC分类号： C07D405/06 , C07D243/14 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/10
摘要： The invention is concerned with novel diazepan derivatives of formula (I) wherein A, X, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.
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27.发明授权CHIRALE OXAZOLE-ARYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS 有权手性OXAZOLYLARYLPROPIONSÄURE衍生物及其作为PPAR激动剂
公开(公告)号：EP1551814B1
公开(公告)日：2008-07-23
申请号：EP03757914.1
申请日：2003-10-06
发明人： BINGGELI, Alfred , BOEHRINGER, Markus , GRETHER, Uwe , HILPERT, Hans , HIRTH, Georges , MAERKI, Hans-Peter , MEYER, Markus , MOHR, Peter , RICKLIN, Fabienne
IPC分类号： C07D263/32 , A61K31/421 , A61P3/10
CPC分类号： C07D263/32
摘要： The present invention relates to compounds of Formula (I), wherein R1 to R6 and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment and/or prevention of diseases, which are modulated by PPARα and/or PPARϜ agonists as e.g. type II diabetes.
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公开(公告)号：EP1877404A2
公开(公告)日：2008-01-16
申请号：EP06777206.1
申请日：2006-04-24
发明人： GROEBKE-ZBINDEN, Katrin , HAAP, Wolfgang , HILPERT, Hans , PANDAY, Narendra , RICKLIN, Fabienne , WIRZ, Beat
IPC分类号： C07D409/14 , C07D413/14 , C07D401/14 , C07D513/04 , C07D207/16 , C07D207/14 , C07D207/12 , A61K31/4025 , A61P7/02
CPC分类号： C07D207/12 , C07D207/14 , C07D207/16 , C07D401/14 , C07D409/14 , C07D413/14 , C07D513/04
摘要： The invention is concerned with novel cyclic amines of formula (I) wherein X1 to X3, Y1 to Y3, R1’ , R1’’ and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
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29.发明公开CHIRALE OXAZOLE-ARYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS 有权手性OXAZOLYLARYLPROPIONSÄURE衍生物及其作为PPAR激动剂
公开(公告)号：EP1551814A1
公开(公告)日：2005-07-13
申请号：EP03757914.1
申请日：2003-10-06
发明人： BINGGELI, Alfred , BOEHRINGER, Markus , GRETHER, Uwe , HILPERT, Hans , HIRTH, Georges , MAERKI, Hans-Peter , MEYER, Markus , MOHR, Peter , RICKLIN, Fabienne
IPC分类号： C07D263/32 , A61K31/421 , A61P3/10
CPC分类号： C07D263/32
摘要： The present invention relates to compounds of Formula (I), wherein R1 to R6 and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment and/or prevention of diseases, which are modulated by PPARα and/or PPARϜ agonists as e.g. type II diabetes.
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30.发明公开CARBOXYLIC ACID SUBSTITUTED OXAZOLE DERIVATIVES FOR USE AS PPAR-ALPHA AND -GAMMA ACTIVATORS IN THE TREATMENT OF DIABETES 有权羧酸取代恶唑衍生物FOR USE AS PPAR-α和-gamma活化剂以治疗糖尿病
公开(公告)号：EP1392295A1
公开(公告)日：2004-03-03
申请号：EP02742955.4
申请日：2002-05-06
发明人： BINGGELI, Alfred , BOEHRINGER, Markus , GRETHER, Uwe , HILPERT, Hans , MAERKI, Hans-Peter , MEYER, Markus , MOHR, Peter , RICKLIN, Fabienne
IPC分类号： A61K31/421 , A61K31/422 , A61P3/10 , C07D263/22 , C07D413/12
CPC分类号： C07D413/12 , C07D263/32 , C07D413/14
摘要： The present invention relates to compounds of formula (I) wherein R1 to R7 are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.
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