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1.发明授权CARBOXYLIC ACID SUBSTITUTED OXAZOLE DERIVATIVES FOR USE AS PPAR-ALPHA AND -GAMMA ACTIVATORS IN THE TREATMENT OF DIABETES 有权羧酸取代恶唑衍生物FOR USE AS PPAR-α和-gamma活化剂以治疗糖尿病
公开(公告)号：EP1392295B1
公开(公告)日：2006-05-31
申请号：EP02742955.4
申请日：2002-05-06
发明人： BINGGELI, Alfred , BOEHRINGER, Markus , GRETHER, Uwe , HILPERT, Hans , MAERKI, Hans-Peter , MEYER, Markus , MOHR, Peter , RICKLIN, Fabienne
IPC分类号： A61K31/421 , A61K31/422 , A61P3/10 , C07D263/22 , C07D413/12
CPC分类号： C07D413/12 , C07D263/32 , C07D413/14
摘要： The present invention relates to compounds of formula (I) wherein R1 to R7 are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.
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公开(公告)号：EP1833782B1
公开(公告)日：2009-04-08
申请号：EP05817968.0
申请日：2005-12-14
发明人： BOEHRINGER, Markus , HUNZIKER, Daniel , KUHN, Bernd , LOEFFLER, Bernd, Michael , MARTY, Hans, Peter , MATTEI, Patrizio , NARQUIZIAN, Robert
IPC分类号： C07C211/35 , C07D207/26 , C07D207/32 , A61K31/135 , A61K31/4015 , A61K31/4418
CPC分类号： C07C211/35 , C07D207/27 , C07D207/325
摘要： The present invention relates to compounds of formula (I) wherein Rl is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
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公开(公告)号：EP1948639A2
公开(公告)日：2008-07-30
申请号：EP06829926.2
申请日：2006-11-01
发明人： BOEHRINGER, Markus , GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , PANDAY, Narendra , RICKLIN, Fabienne , STAHL, Martin , SCHMITZ, Petra
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention is concerned with novel carbocyclyl fused cyclic amines of formula (I) wherein A, X1 to X3, Y1 to Y3, Z, R1, R2, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
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公开(公告)号：EP1476429A1
公开(公告)日：2004-11-17
申请号：EP03704539.0
申请日：2003-02-05
发明人： BOEHRINGER, Markus , LOEFFLER, Bernd, Michael , PETERS, Jens-Uwe , RIEMER, Claus , WEISS, Peter
IPC分类号： C07D215/38 , C07D221/16 , C07D491/04 , C07D495/04 , A61K31/435 , A61K31/47 , A61P1/04 , A61P3/10
CPC分类号： C07D215/38 , C07D221/16 , C07D491/04 , C07D495/04
摘要： The present invention relates to compounds of formula (I), wherein Rl, R2, R3 and R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
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5.发明授权N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS 有权N-二SUBSTITUIRTE吡咯烷衍生物作为抑制剂二肽酶
公开(公告)号：EP1441719B1
公开(公告)日：2011-03-30
申请号：EP02777318.3
申请日：2002-10-18
发明人： BOEHRINGER, Markus , HUNZIKER, Daniel , KUEHNE, Holger , LOEFFLER, Bernd, Michael , SARABU, Ramakanth , WESSEL, Hans, Peter
IPC分类号： A61K31/401 , A61K31/4155 , A61K31/4025 , A61K31/4178 , A61K31/416 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/454 , C07D207/16 , C07D403/12 , C07D471/04 , C07D413/12 , C07D401/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D401/14 , C07D409/14 , C07D403/14 , C07D513/04
CPC分类号： C07D277/06 , A61K9/0019 , A61K9/1623 , A61K9/2853 , A61K9/2866 , A61K9/4825 , A61K9/4858 , A61K9/4875 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I), wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
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6.发明授权
公开(公告)号：EP1638970B1
公开(公告)日：2010-11-24
申请号：EP04739841.7
申请日：2004-06-11
IPC分类号： C07D471/06 , A61P3/10
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2853 , A61K9/2866 , A61K9/4825 , A61K9/4858 , A61K9/4875
摘要： The present invention relates to compounds of formula (I) wherein R1, R2 R3 and R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
摘要翻译： 本发明涉及式（I）的化合物及其药学上可接受的盐，其中R 1，R 2，R 3和R 4如说明书和权利要求书中所定义。 该化合物可用于治疗和/或预防与DPP-IV相关的疾病，例如糖尿病，特别是非胰岛素依赖性糖尿病和葡萄糖耐量降低。
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7.发明公开
公开(公告)号：EP1638970A1
公开(公告)日：2006-03-29
申请号：EP04739841.7
申请日：2004-06-11
IPC分类号： C07D471/06 , A61P3/10
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2853 , A61K9/2866 , A61K9/4825 , A61K9/4858 , A61K9/4875
摘要： The present invention relates to compounds of formula (I) wherein R1, R2 R3 and R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
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公开(公告)号：EP1476435B1
公开(公告)日：2010-06-30
申请号：EP03704536.6
申请日：2003-02-05
发明人： BOEHRINGER, Markus , LOEFFLER, Bernd, Michael , PETERS, Jens-Uwe , STEGER, Matthias , WEISS, Peter
IPC分类号： C07D239/42 , C07D213/73 , C07D401/04 , C07D405/04 , C07D409/04 , A61K31/505 , A61P3/10
CPC分类号： C07D213/73 , C07D239/42 , C07D401/04 , C07D405/04 , C07D409/04
摘要： The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4 and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
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公开(公告)号：EP1907388A1
公开(公告)日：2008-04-09
申请号：EP06764077.1
申请日：2006-07-05
发明人： BOEHRINGER, Markus , GROEBKE ZBINDEN, Katrin , HAAP, Wolfgang , HILPERT, Hans , PANDAY, Narendra , RICKLIN, Fabienne
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4162 , A61K31/4355 , A61K31/4375 , A61P7/02
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention is concerned with novel heteroaryl fused cyclic amines of formula (I) wherein A, X1 to X3, Y1 to Y3, Z, R1, R2, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型杂芳基稠合环胺，其中A，X 1至X 3，Y 1至Y 3，Z，R 1，R 2，m和n如说明书和权利要求书中所定义，以及生理学上 其可接受的盐。 这些化合物抑制凝血因子Xa并可用作药物。
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公开(公告)号：EP1476429B1
公开(公告)日：2005-11-16
申请号：EP03704539.0
申请日：2003-02-05
发明人： BOEHRINGER, Markus , LOEFFLER, Bernd, Michael , PETERS, Jens-Uwe , RIEMER, Claus , WEISS, Peter
IPC分类号： C07D215/38 , C07D221/16 , C07D491/04 , C07D495/04 , A61K31/435 , A61K31/47 , A61P1/04 , A61P3/10
CPC分类号： C07D215/38 , C07D221/16 , C07D491/04 , C07D495/04
摘要： The present invention relates to compounds of formula (I), wherein Rl, R2, R3 and R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
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