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公开(公告)号：EP2935306B1
公开(公告)日：2016-11-30
申请号：EP13808024.7
申请日：2013-12-18
CPC分类号： C12Q1/6876 , C07H21/00 , C12Q1/686 , C12Q2535/131 , C12Q2563/107
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公开(公告)号：EP3083992A1
公开(公告)日：2016-10-26
申请号：EP14821146.9
申请日：2014-12-18
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/686 , C12Q2549/10 , C12Q2563/107
摘要： The present invention provides for methods and compositions that use fluorescent dyes for the identification of reagents and solutions that are used to perform PCR assays.
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23.发明公开METHODS AND COMPOSITIONS FOR DETECTING MUTATION IN THE HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR GENE 审中-公开方法和组合物检测突变人类表皮生长因子受体基因
公开(公告)号：EP2655659A2
公开(公告)日：2013-10-30
申请号：EP11808168.6
申请日：2011-12-17
发明人： BAUER, Keith , SCHOENBRUNNER, Nancy , TSAN, Alison
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/156
摘要： The invention comprises reagents and methods for detecting cancer- causing mutations in the human EGFR gene. Further, a method of detecting the mutations and a method of treatment are disclosed.
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24.发明公开NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF MIXTURES BY DEEP SEQUENCING OF HLA GENE AMPLICONS USING NEXT GENERATION SYSTEMS 审中-公开移植固体的无创的早期检测BY BY混合体HLA-GEN组的深度测序的定量分析手段扩增子系统的下一代BASIS
公开(公告)号：EP2994539A1
公开(公告)日：2016-03-16
申请号：EP14722660.9
申请日：2014-05-07
发明人： ERLICH, Henry, A. , HOGLUND, Bryan , HOLCOMB, Cherie , MOONSAMY, Priscilla , NEWTON, Nicolas , RASTROU, Melinda , SALOMON, Daniel, R. , SCHOENBRUNNER, Nancy , TSAN, Alison
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/118
摘要： The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
摘要翻译： 本发明是检测或通过接枝（移植）接受者的血液样品中检测的供体特异性的HLA等位基因assesing实体器官移植物（移植）排斥的方法。 本发明还包括检测后代的血液样品中的母体细胞的存在的方法。
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公开(公告)号：EP2935306A1
公开(公告)日：2015-10-28
申请号：EP13808024.7
申请日：2013-12-18
CPC分类号： C12Q1/6876 , C07H21/00 , C12Q1/686 , C12Q2535/131 , C12Q2563/107
摘要： The present invention is directed to methods for generating a labeled oligonucleotide probe that contains a fluorescent rhodamine-derived dye for use in PCR reactions to detect a target nucleic acid.
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公开(公告)号：EP1761640B1
公开(公告)日：2010-06-02
申请号：EP05737453.0
申请日：2005-05-04
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods of detecting cancer cells by detecting the quantity of SENP1 and/or telomerase in a sample.
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公开(公告)号：EP2785863B1
公开(公告)日：2016-08-24
申请号：EP12801454.5
申请日：2012-11-30
发明人： CHEN, Xiaoying , CHENG, Suzanne , MYERS, Thomas W. , PATTEN, Nancy , SCHOENBRUNNER, Nancy , TRUONG, Sim-Jasmine C.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6848 , C12N15/11 , C12Q1/6858 , G06F17/50 , G06F19/12 , G06F19/22 , C12Q2537/163 , C12Q2549/126
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28.发明公开
公开(公告)号：EP2935619A1
公开(公告)日：2015-10-28
申请号：EP13814889.5
申请日：2013-12-19
发明人： GUPTA, Amar , SCHOENBRUNNER, Nancy
CPC分类号： C12Q1/6806 , C07F15/0073 , C12Q1/6827 , C12Q2535/131 , C12Q2537/113 , C12Q2563/173
摘要： The detection of the presence of rare somatic mutations from a biological sample is often challenging due to the simultaneous presence of a vast excess of wild-type DNA. The present invention describes novel compounds and methods that would allow the enrichment of mutant DNA by depleting amplifiable wild-type DNA.
摘要翻译： 罕见的体细胞突变的来自生物样品的存在的检测是经常具有挑战性，因为广大过量野生型DNA的同时存在。 本发明描述了新的化合物和方法做将允许突变体DNA的富集通过耗尽扩增野生型DNA。
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公开(公告)号：EP2785863A1
公开(公告)日：2014-10-08
申请号：EP12801454.5
申请日：2012-11-30
发明人： CHEN, Xiaoying , CHENG, Suzanne , MYERS, Thomas W. , PATTEN, Nancy , SCHOENBRUNNER, Nancy , TRUONG, Sim-Jasmine C.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6848 , C12N15/11 , C12Q1/6858 , G06F17/50 , G06F19/12 , G06F19/22 , C12Q2537/163 , C12Q2549/126
摘要： The invention comprises suppressor oligonucleotides for reducing amplification of a non- target nucleic acid sequences; the method of designing and using such oligonucleotides, as well as kits and reaction mixtures.
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30.发明公开USE OF G-CLAMP FOR IMPROVED ALLELE-SPECIFIC PCR 有权VERWENDUNG VON G-CLAMPFÜRVERBESSERTE ALLELSPEZIFISCHE PCR
公开(公告)号：EP2758546A1
公开(公告)日：2014-07-30
申请号：EP12770415.3
申请日：2012-09-12
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , C12Q2525/117 , C12Q2535/125
摘要： The present invention includes a method of allele-specific amplification, utilizing an allele- specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having at least one selective nucleotide complementary to only one variant of the target sequence and incorporating at least one "G-clamp" nucleotide.
摘要翻译： 本发明包括等位基因特异性扩增的方法，利用与靶序列的多于一个变体至少部分互补的等位基因特异性寡核苷酸，但具有至少一个与靶序列的一个变体互补的选择性核苷酸， 并入至少一个“G-钳”核苷酸。
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