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1.发明公开NON-INVASIVE EARLY DETECTION OF SOLID ORGAN TRANSPLANT REJECTION BY QUANTITATIVE ANALYSIS OF MIXTURES BY DEEP SEQUENCING OF HLA GENE AMPLICONS USING NEXT GENERATION SYSTEMS 审中-公开移植固体的无创的早期检测BY BY混合体HLA-GEN组的深度测序的定量分析手段扩增子系统的下一代BASIS
公开(公告)号：EP2994539A1
公开(公告)日：2016-03-16
申请号：EP14722660.9
申请日：2014-05-07
发明人： ERLICH, Henry, A. , HOGLUND, Bryan , HOLCOMB, Cherie , MOONSAMY, Priscilla , NEWTON, Nicolas , RASTROU, Melinda , SALOMON, Daniel, R. , SCHOENBRUNNER, Nancy , TSAN, Alison
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/118
摘要： The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
摘要翻译： 本发明是检测或通过接枝（移植）接受者的血液样品中检测的供体特异性的HLA等位基因assesing实体器官移植物（移植）排斥的方法。 本发明还包括检测后代的血液样品中的母体细胞的存在的方法。
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公开(公告)号：EP1761640A1
公开(公告)日：2007-03-14
申请号：EP05737453.0
申请日：2005-05-04
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods of detecting cancer cells by detecting the quantity of SENP1 and/or telomerase in a sample.
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公开(公告)号：EP1761640B1
公开(公告)日：2010-06-02
申请号：EP05737453.0
申请日：2005-05-04
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods of detecting cancer cells by detecting the quantity of SENP1 and/or telomerase in a sample.
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4.发明公开METHOD OF DETERMINING THE FRACTION OF FETAL DNA IN MATERNAL BLOOD USING HLA MARKERS 审中-公开PROCEDURE测定胎儿DNA母体血液的共享HLA-MARKERS
公开(公告)号：EP2994538A1
公开(公告)日：2016-03-16
申请号：EP14722211.1
申请日：2014-05-07
发明人： ERLICH, Henry A. , HOGLUND, Bryan , HOLCOMB, Cherie , MOONSAMY, Priscilla , NEWTON, Nicolas , RASTROU, Melinda , TSAN, Alison , SCHOENBRUNNER, Nancy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： The invention comprises a method of determining the fraction of fetal DNA in maternal blood or plasma using HLA locus wherein the maternal and fetal HLA alleles are detected and quantified by clonal or digital methods.
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公开(公告)号：EP2419530A1
公开(公告)日：2012-02-22
申请号：EP10714201.0
申请日：2010-04-15
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6869 , C12Q2600/156 , C12Q2535/122
摘要： A method for detecting one or more HLA sequence types is described that comprises the steps of: amplifying a plurality of first amplicons from a double stranded nucleic acid sample, wherein the first amplicons are amplified with a plurality of pairs of nucleic acid primers that define exons 2 and 3 of both strands of HLA loci from the group consisting of HLA-A, HLA-B, and HLA-C; amplifying the first amplicons to produce a plurality of populations of second amplicons, wherein each population of second amplicons is clonally amplified from one of the first amplicons; sequencing the plurality of populations of second amplicons to generate a nucleic acid sequence composition for each of the plurality of second amplicons; and detecting variation in the sequence composition from one or more of the second amplicons for one or more of the HLA loci..
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公开(公告)号：EP3510153A1
公开(公告)日：2019-07-17
申请号：EP17777180.5
申请日：2017-09-12
发明人： BELLARE, Priya , HOLCOMB, Cherie , CASILLA, Alan , HRYCE, Trevor , RUAN, Qiao , KAMPANI, Karan , KOZLOV, Igor
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公开(公告)号：EP3400308B1
公开(公告)日：2020-02-19
申请号：EP17701273.9
申请日：2017-01-04
发明人： HOLCOMB, Cherie , CASILLA, Alan , GRISWOLD, Jennifer , HRYCE, Trevor , KAMPANI, Karan , LEGASPI, Sharon
IPC分类号： C12Q1/6806 , C12N15/10
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公开(公告)号：EP3400308A1
公开(公告)日：2018-11-14
申请号：EP17701273.9
申请日：2017-01-04
发明人： HOLCOMB, Cherie , CASILLA, Alan , GRISWOLD, Jennifer , HRYCE, Trevor , KAMPANI, Karan , LEGASPI, Sharon
摘要： Provided herein are methods and components for successive capture of nucleic acids using magnetic glass particles.
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