公开(公告)号：EP2571355B1

公开(公告)日：2016-09-07

申请号：EP10851696.4

申请日：2010-05-20

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  RAJI REDDY, Rapolu ,  VAMSI KRISHNA, Bandi ,  SUBASH CHANDER REDDY, Kesireddy

IPC分类号： A01N43/08 ,  A61K31/34

CPC分类号： C07D493/04 ,  C07D307/93

公开(公告)号：EP2499125B1

公开(公告)日：2016-01-27

申请号：EP09851229.6

申请日：2009-11-12

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  RAJI REDDY, Rapolu ,  MURALIDHARA REDDY, Dasari ,  VAMSI KRISHNA, Bandi ,  RAMESH REDDY, Voggu

IPC分类号： C07D401/12

CPC分类号： C07D401/12 ,  C07D401/14

公开(公告)号：EP2760853A1

公开(公告)日：2014-08-06

申请号：EP12836162.3

申请日：2012-09-12

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  MOHANBABU, Maradolla ,  VAMSI KRISHNA, Bandi

IPC分类号： C07D401/04

CPC分类号： C07D401/04

摘要： The present invention provides a novel process for the preparation of amorphous alogliptin benzoate. The present invention also provides amorphous alogliptin benzoate co-precipitated on copovidone, process for its preparation and pharmaceutical compositions comprising it. The present invention further provides novel salts of alogliptin, processes for their preparation and pharmaceutical compositions comprising them. The present invention further provides crystalline hydrochloride salt of alogliptin, process for its preparation and pharmaceutical compositions comprising it. The present invention further provides crystalline tartrate salt of alogliptin, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明提供了制备无定形阿格列汀苯甲酸酯的新方法。 本发明还提供了在共聚维酮上共沉淀的无定形阿格列汀苯甲酸酯，其制备方法和包含它的药物组合物。 本发明进一步提供了奥曲霉素的新型盐，其制备方法和包含它们的药物组合物。 本发明进一步提供了一种钠离子的结晶盐酸盐，其制备方法和包含它的药物组合物。 本发明还提供了一种奥曲肽的结晶酒石酸盐，其制备方法和包含它的药物组合物。

公开(公告)号：EP2744573A2

公开(公告)日：2014-06-25

申请号：EP12823566.0

申请日：2012-08-13

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  VAMSI KRISHNA, Bandi

IPC分类号： A61P31/18

CPC分类号： A61K31/513 ,  A61K9/146 ,  A61K9/2027 ,  A61K31/427 ,  A61K2300/00

摘要： The present invention relates to amorphous mixture of lopinavir and ritonavir co-precipitated on copovidone, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明涉及共沉淀在共聚维酮上的洛匹那韦和利托那韦的无定形混合物，其制备方法和包含它的药物组合物。

公开(公告)号：EP2720547A2

公开(公告)日：2014-04-23

申请号：EP12803460.0

申请日：2012-05-24

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  VAMSI KRISHNA, Bandi

IPC分类号： A01N43/52

CPC分类号： C07D235/16 ,  C07D513/04

摘要： The present invention provides a process for the preparation of 1H-benzimidazol-1-methyl-5-N,N-di(2-hydroxyethyl)-2-butanoic acid ethyl ester. The present invention also provides a process for the preparation of bendamustine hydrochloride. The present invention further provides a process for the purification of bendamustine hydrochloride.

摘要翻译： 本发明提供了制备1H-苯并咪唑-1-甲基-5-N，N-二（2-羟乙基）-2-丁酸乙酯的方法。 本发明还提供了制备盐酸苯达莫司汀的方法。 本发明还提供了一种纯化盐酸苯达莫司汀的方法。

公开(公告)号：EP2714683A2

公开(公告)日：2014-04-09

申请号：EP12792066.8

申请日：2012-05-21

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  VAMSI KRISHNA, Bandi

IPC分类号： C07D417/02 ,  A61K31/427

CPC分类号： C07D277/28 ,  A61K31/427 ,  A61K45/06 ,  A61K47/32

摘要： The present invention relates to amorphous ritonavir co-precipitated on copovidone, process for its preparation and pharmaceutical compositions comprising it.

公开(公告)号：EP2683378A2

公开(公告)日：2014-01-15

申请号：EP12754225.6

申请日：2012-03-05

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  SUBASH CHANDER REDDY, Kesireddy ,  VAMSI KRISHNA, Bandi

IPC分类号： A61K31/426

CPC分类号： A61K31/513 ,  A61K31/427 ,  C07D239/10 ,  C07D417/12 ,  A61K2300/00

摘要： The present invention relates to a novel amorphous Form of lopinavir and ritonavir mixture in the ratio of 3.8: 1.2 to 4.2:0.8, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明涉及比例为3.8：1.2至4.2：0.8的新型无定形形式的洛匹那韦和利托那韦混合物，其制备方法和包含其的药物组合物。

公开(公告)号：EP2638013A1

公开(公告)日：2013-09-18

申请号：EP11840517.4

申请日：2011-08-23

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  MALLA REDDY, Samala ,  VAMSI KRISHNA, Bandi

IPC分类号： C07D215/16

CPC分类号： C07D215/04 ,  C07D215/14 ,  C07D215/16

摘要： The present invention provides a solid of pitavastatin tert-butyl ester and process for its preparation. The present invention also provides a novel crystalline form of pitavastatin calcium, process for its preparation and pharmaceutical compositions comprising it.

摘要翻译： 本发明提供了匹伐他汀叔丁酯的固体及其制备方法。 本发明还提供了匹伐他汀钙的新型结晶形式，其制备方法和包含它的药物组合物。

公开(公告)号：EP2584901A1

公开(公告)日：2013-05-01

申请号：EP10854026.1

申请日：2010-06-28

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  RAJI REDDY, Rapolu ,  VAMSI KRISHNA, Bandi ,  VENKAT NARSIMHA REDDY, Adulla

IPC分类号： A01N43/54 ,  A61K31/505

CPC分类号： C07D239/47 ,  A61K31/505

摘要： 4-[[6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-benzonitrile is a key intermediate for the preparation of etravirine. The present invention provides a process for preparation of 4-[[6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile. The present invention also provides a novel process for the preparation of etravirine crystalline form I. The present invention further provides novel crystalline forms of etravirine, processes for their preparation and pharmaceutical compositions comprising them.

公开(公告)号：EP2555616A1

公开(公告)日：2013-02-13

申请号：EP10849334.7

申请日：2010-04-08

申请人： Hetero Research Foundation

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, Kura ,  MURALIDHARA REDDY, Dasari ,  RAJI REDDY, Rapolu ,  RAMAKRISHNA REDDY, Matta ,  VAMSI KRISHNA, Bandi

IPC分类号： A01N33/02 ,  A61K31/13

CPC分类号： C07C231/22 ,  C07C17/06 ,  C07C209/62 ,  C07C209/84 ,  C07C231/10 ,  C07C2603/74 ,  C07C233/06 ,  C07C211/38 ,  C07C23/46

摘要： The present invention provides an improved process for the preparation of 1-bromo-3,5-dimethyladamantane. The present invention also provides a process for preparing free flowing solid of 1-acetamido-3,5-dimethyladamantane. The present invention further provides a process for the preparation of memantine hydrochloride substantially free of 1-amino-3,5,7-trimethyladamantane hydrochloride and/or 1-amino-3-methyladamantane hydrochloride impurity.

摘要翻译： 本发明提供了制备1-溴-3,5-二甲基金刚烷的改进方法。 本发明还提供了制备1-乙酰氨基-3,5-二甲基金刚烷的自由流动固体的方法。 本发明还提供了一种制备基本上不含1-氨基-3,5,7-三甲基金刚烷盐酸盐和/或1-氨基-3-甲基金刚烷盐酸盐杂质的美金刚盐酸盐的方法。