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公开(公告)号：EP2086938B1
公开(公告)日：2012-01-25
申请号：EP07862645.4
申请日：2007-12-07
申请人： Novartis AG
IPC分类号： C07D213/75 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/06 , A61K31/44 , A61P35/00
CPC分类号： C07D405/12 , C07D213/75 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/06
摘要： The present disclosure relates to XIAP inhibitor compound of the formula I: [Chemical formula should be inserted here as it appears on Abstract in paper form] Formula I
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22.发明公开6-OXO.-1, 6-DIHYDROPYRIMIDIN-2-YLS IN THE TREATMENT OF PROLIFERATIVE DISEASES 有权6-氧代-1,6-二氢-2- YLE在治疗增殖性疾病
公开(公告)号：EP2099769A1
公开(公告)日：2009-09-16
申请号：EP07862644.7
申请日：2007-12-07
申请人： NOVARTIS AG
IPC分类号： C07D233/96 , C07D241/18 , C07D403/10
CPC分类号： C07D241/20 , C07D239/47 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D417/06
摘要： The present invention relates to novel IAP inhibitor compounds of Formula (I)
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公开(公告)号：EP2089024A2
公开(公告)日：2009-08-19
申请号：EP07868853.8
申请日：2007-11-27
IPC分类号： A61K31/427 , A61K31/437 , A61K31/553 , A61K31/704 , A61K31/7068 , A61P35/00
CPC分类号： A61K31/553 , A61K31/427 , A61K31/437 , A61K31/704 , A61K31/7068 , A61K2300/00
摘要： The present invention relates to combinations of IAP inhibitors and FLT3 inhibitors, pharmacological compositions comprising said combination, methods of treating hematological malignancies, including acute myeloid leukemia (AML), comprising the combination of a compound that inhibits the binding of the second mitochondria-derived activator of caspase (Smac) protein to inhibitor of apoptosis (IAPs) (IAP inhibitor) and one or more pharmaceutically active agents and the use of these combinations for the treatment of acute myeloid leukemia; and a commercial package comprising said combination.
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