公开(公告)号：EP0058057A1

公开(公告)日：1982-08-18

申请号：EP82300567.3

申请日：1982-02-04

申请人： Takeda Chemical Industries, Ltd.

发明人： Watanabe, Masazumi ,  Imada, Isuke

IPC分类号： C07C50/28 ,  C07C46/06 ,  C07C46/00 ,  C07C69/14

CPC分类号： C07C50/28 ,  C07C43/2055 ,  C07C43/23 ,  C07C46/00

摘要： A compound of the formula
wherein R stands for an alkyl group having 1 to 22 carbon atoms and having at its terminal end a hydroxyl group which may be protected can be obtained with an industrial advantage by allowing a compound representable by the formula;
to react with a peroxide of a carboxylic acid representable by the formula; RCOOH wherein R is of the same meaning as defined above, or with a peroxide of an acid anhydride of the carboxylic acid.
A compound of the formula;
wherein R 2 stands for an alkyl group having 1 to 2 carbon atoms and having at its terminal end an optionally protected hydroxyl group, is a novel compound and has antifibrotic activity.

摘要翻译： 其中R代表具有1至22个碳原子的烷基并且其末端具有可被保护的羟基的化合物可通过工业上的优点得到，通过使化合物可被 式; ... ...与由式表示的羧酸的过氧化物反应; ... RCOOH ...其中R与上述定义相同，或与羧酸的酸酐的过氧化物反应。 一种式的化合物; ... ...其中R 2代表具有1至2个碳原子的烷基，并且在其末端具有任选保护的羟基，是新化合物并具有抗纤维化活性。

公开(公告)号：EP0038576A3

公开(公告)日：1981-11-18

申请号：EP81104398

申请日：1980-05-01

申请人： Takeda Chemical Industries, Ltd.

发明人： Sugihara, Hirosada ,  Watanabe, Masazumi ,  Kawada, Mitsuru ,  Imada, Isuke

IPC分类号： C07D307/94 ,  A61K31/34 ,  C07D307/32

CPC分类号： C07D307/33 ,  C07D307/94 ,  C07D493/10

摘要： A novel 7-acetylspirobenzofuranone compound of the formula:
has gastric secretion inhibitive, antiiflammatory and analgesic activities, and is of value as a drug.