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22 条记录 (耗时 0.01 秒)

    Spirobenzofuranones, their production and use
    3.
    发明公开
    Spirobenzofuranones, their production and use 失效
    SPIROBENZOFURANONES，其生产和使用

    公开(公告)号：EP0018830A3

    公开(公告)日：1980-12-10

    申请号：EP80301431

    申请日：1980-05-01

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Sugihara, Hirosada ,  Watanabe, Masazumi ,  Kawada, Mitsuru ,  Imada, Isuke

    IPC分类号： C07D307/94 ,  A61K31/34

    CPC分类号： C07D307/33 ,  C07D307/94 ,  C07D493/10

    摘要： Novel spirobenzofuranone compounds of the formula:
    wherein Ring A represents a benzene ring which is substituted by at least one of carboxyl, lower alkoxycarbonyl, carbamoyl which may be substituted, ureido which may be substituted, thioureido which may be substituted, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, mono- or bis-(β-hydroxyethyl) amino, aminoethyl which may be substituted, cyano and phenyl, and pharmaceutically acceptable salts thereof, have gastric secretion inhibitive, antiinflammatory and analgesic activities, and are of value as drugs. The invention relates to such compounds, to processes for their production and to their use as drugs.

    Hair revitalizing tonic composition containing a 2,2-dimethylpropanediol compound and use thereof
    4.
    发明公开
    Hair revitalizing tonic composition containing a 2,2-dimethylpropanediol compound and use thereof 失效
    2,2-二甲基丙酸酯衍生物

    公开(公告)号：EP0823251A2

    公开(公告)日：1998-02-11

    申请号：EP97113699.9

    申请日：1997-08-07

    申请人： SHISEIDO COMPANY LIMITED ,  TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Magara, Tsunao ,  Tsuji, Yoshiharu ,  Tajima, Masahiro ,  Kobayashi, Koji ,  Fukunishi, Hirotada ,  Watanabe, Masazumi

    IPC分类号： A61K7/06

    CPC分类号： A61Q7/00 ,  A61K8/44 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/494 ,  A61Q5/02

    摘要： Disclosed is a hair revitalizing tonic composition containing a dimethylpropanediol derivative of the formula:

    wherein R 1 and R 2 are each independently a C 1-30 hydrocarbon group which may be substituted, or a five- or six-membered heterocyclic group which contains 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen atoms and which may be substituted, R 3 is hydrogen atom, an alkyl group which may be substituted, an acyl group, an alkoxycarbonyl group, a phenoxycarbonyl group, or a carbamoyl group which may be substituted, and a and b are each 0 or 1, as well as a method for effecting hair growth promotion, hair growth stimulation, or hair loss prevention in mammals by using such a hair revitalizing tonic composition. Also disclosed is the use of a compound of formula (I) in the preparation of a hair revitalizing tonic composition. Thus, this invention can provide an excellent means of hair revitalization or hair loss prevention in mammals.

    摘要翻译： 本发明公开了一种含有下式的二甲基丙二醇衍生物的头发活力补品组合物：其中R 1和R 2各自独立地为可被取代的C 1-30烃基，或五元或六元 含有1至4个选自氧，硫和氮原子并且可以被取代的杂原子的杂环基，R 3是氢原子，可以被取代的烷基，酰基，烷氧基羰基，苯氧基羰基， 或可以被取代的氨基甲酰基，a和b各自为0或1，以及通过使用这种头发活化的补品组合物来实现哺乳动物的毛发生长促进，毛发生长刺激或脱发防止的方法。 还公开了式（I）化合物在制备头发活化滋补组合物中的用途。 因此，本发明可以提供哺乳动物的头发复兴或脱发预防的优良手段。

    Benzoquinone derivatives, their production and use
    9.
    发明公开
    Benzoquinone derivatives, their production and use 失效
    苯醌衍生物，它们的生产和使用

    公开(公告)号：EP0201196A2

    公开(公告)日：1986-12-17

    申请号：EP86302464.2

    申请日：1986-04-03

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Watanabe, Masazumi ,  Imada, Isuke

    IPC分类号： C07C50/28 ,  C07C46/06 ,  C07C46/00 ,  C07C69/145 ,  A61K31/12

    摘要： Compounds of the formula:
    wherein ℓ is an integer of 0 to 18, X is hydrogen, an alkyl having 1 to 4 carbon atoms or a carboxylic "acyl having 2 to 4 carbon atoms and Y is a phenylene, a cycloalkylene having 3 to 7 carbon atoms or a group of the formula:
    in which m is an integer of 0 to 3, and R, and R 2 each is an alkyl having 1 to 4 carbon atoms, are novel compounds, possess circulatory disturbance-improving activity and inhibitory activity of the generation and release of SRS-A, and used for prophylactic or therapy of ischemic diseases such as cerebral apoplexy or allergic diseases.

    摘要翻译： 下式化合物：其中l为0至18的整数，X为氢，具有1至4个碳原子的烷基或具有2至4个碳原子的羧酸“酰基，Y为亚苯基，具有3至7个亚环烷基 碳原子或下式的基团：其中m是0-3的整数，R 1和R 2各自是具有1至4个碳原子的烷基，是新化合物，具有循环障碍改善活性和抑制活性 SRS-A的产生和释放，并用于预防或治疗脑卒中或过敏性疾病等缺血性疾病。