公开(公告)号：EP0980435A1

公开(公告)日：2000-02-23

申请号：EP98918909.7

申请日：1998-05-01

申请人： ZymoGenetics, Inc.

发明人： LOK, Si ,  JASPERS, Stephen, R.

IPC分类号： C12N15/55 ,  C12N5/10 ,  C12N15/62 ,  C12N9/64 ,  C07K16/40

CPC分类号： C12N9/6454 ,  C07K2319/00

摘要： The present invention provides polynucleotide and polypeptide molecules for a novel human prohormone convertase 4. The polynucleotides encoding human prohormone convertase 4, are located on chromosome (19), and may, for example, be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein and antibodies thereto.

公开(公告)号：EP0918859A1

公开(公告)日：1999-06-02

申请号：EP97937147.0

申请日：1997-08-01

申请人： ZymoGenetics, Inc.

发明人： LOK, Si ,  CONKLIN, Darrell C. ,  ADAMS, Robyn, L. ,  JELMBERG, Anna, C. ,  LOFTON-DAY, Catherine, E. ,  JASPERS, Stephen, R.

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K48 ,  A61P15 ,  A61P43 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12P21

CPC分类号： C07K14/62 ,  A61K38/00 ,  C07K14/64

摘要： The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.