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公开(公告)号：EP1237921A1
公开(公告)日：2002-09-11
申请号：EP00973811.3
申请日：2000-10-23
申请人： ZymoGenetics, Inc.
发明人： XU, Wenfeng , LOFTON-DAY, Catherine, E. , HENNE, Randall , PRESNELL, Scott, R. , YAO, Yue , NOVAK, Julia, E. , FOSTER, Donald, C. , YEE, David, P.
CPC分类号： C07K14/7151
摘要： Novel secreted and membrane bound tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligands, agonists and antagonist. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate inflammation, tumor growth and metastasis, infection, immunity, and cellular maturation.
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公开(公告)号：EP0804480A1
公开(公告)日：1997-11-05
申请号：EP95943915.0
申请日：1995-12-20
申请人： ZymoGenetics, Inc.
CPC分类号： C07K14/715 , A61K38/00 , C07K14/52
摘要： Purified mammalian thrombopoietin proteins and methods of making them are disclosed. The proteins are characterized by a Mr=70,000 ± 10,000 daltons as determined by SDS-polyacrylamide gel electrophoresis under denaturing conditions and are at least 90 % pure with respect to contaminating proteins. The proteins can be prepared by a method in which thrombopoietin is adsorbed to and eluted from a polypeptide comprising a ligand-binding domain of an MPL receptor, then the eluted thrombopoieting is fractionated by anion exchange chromatography.
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3.发明公开SECRETED ALPHA-HELICAL PROTEIN ZLMDA24 审中-公开SEKRETIERTES ALPHA-HELICALES CYTOKIN-ÄHNLICHESPROTEIN ZLMDA24
公开(公告)号：EP1328638A2
公开(公告)日：2003-07-23
申请号：EP01988513.6
申请日：2001-10-19
申请人： ZymoGenetics, Inc.
CPC分类号： C07K14/52 , C07K2319/00
摘要： The present invention relates to zlmda24 polynucleotide and polypeptide molecules. Zlmda24 is a novel cytokine-like polypeptide with an anti-parallel alphahelical structure. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. Moreover, zlmda24 polynucleotides, polypeptides and antibodies can be used as a diagnostic to detect the presence of human testis tissue. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
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4.发明授权PURIFIED THROMBOPOIETIN AND METHOD OF MAKING IT 失效GEREINIGTE THROMBOPOIETIN UND VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP0804480B1
公开(公告)日：2006-03-08
申请号：EP95943915.9
申请日：1995-12-20
申请人： ZymoGenetics, Inc.
CPC分类号： C07K14/715 , A61K38/00 , C07K14/52
摘要： Purified mammalian thrombopoietin proteins and methods of making them are disclosed. The proteins are characterized by a Mr=70,000 +/- 10,000 daltons as determined by SDS-polyacrylamide gel electrophoresis under denaturing conditions and are at least 90 % pure with respect to contaminating proteins. The proteins can be prepared by a method in which thrombopoietin is adsorbed to and eluted from a polypeptide comprising a ligand-binding domain of an MPL receptor, then the eluted thrombopoieting is fractionated by anion exchange chromatography.
摘要翻译： 公开了纯化的哺乳动物血小板生成蛋白及其制备方法。 蛋白质的特征在于Mr = 70,000 +/- 10,000道尔顿，在变性条件下通过SDS-聚丙烯酰胺凝胶电泳测定，并且相对于污染蛋白质至少为90％纯度。 蛋白质可以通过其中血小板生成素被吸附到包含MPL受体的配体结合结构域的多肽洗脱的方法来制备，然后通过阴离子交换色谱分离洗脱的血小板生成素。
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公开(公告)号：EP0918859A1
公开(公告)日：1999-06-02
申请号：EP97937147.0
申请日：1997-08-01
申请人： ZymoGenetics, Inc.
发明人： LOK, Si , CONKLIN, Darrell C. , ADAMS, Robyn, L. , JELMBERG, Anna, C. , LOFTON-DAY, Catherine, E. , JASPERS, Stephen, R.
IPC分类号： C12N15 , A61K31 , A61K38 , A61K39 , A61K45 , A61K48 , A61P15 , A61P43 , C07K14 , C07K16 , C12N1 , C12N5 , C12P21
摘要： The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.
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