公开(公告)号：EP1218031B1

公开(公告)日：2006-06-28

申请号：EP00969387.0

申请日：2000-10-02

申请人： Intercell AG

发明人： FLEITMANN, Julia-Kristina ,  MATTNER, Frank ,  BUSCHLE, Michael ,  MELLING, Jack

IPC分类号： A61K39/39 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  A61K39/29

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/29 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55522 ,  A61K2039/55555 ,  A61K2039/55583 ,  C12N2710/16234 ,  C12N2740/16034 ,  C12N2770/24222 ,  C12N2770/24234

摘要： The inventions discloses a pharmaceutical composition comprising an antigen, an immunostimulating substance selected from neuroactive compounds, hormones, compounds having a growth hormone activity, and mixtures thereof, and a polycationic polymer.

公开(公告)号：EP1551869A2

公开(公告)日：2005-07-13

申请号：EP03757983.6

申请日：2003-10-15

申请人： Intercell AG

发明人： REINSCHEID, Dieter, J. ,  GUTEKUNST, Heike ,  SCHUBERT, Axel ,  EIKMANNS, Bernhard, J. ,  MEINKE, Andreas

IPC分类号： C07K14/315

CPC分类号： C07K14/315 ,  A61K39/00

摘要： The present invention is related to nucleic acids coding for adhesion factors of group B streptococcus, adhesion factors of group B streptococcus and uses thereof. More particularly, the present invention is related to a polypeptide being such adhesion factors and comprising an amino acid sequence, whereby the amino acid sequence is selected from the group comprising SEQ ID NO 11 to SEQ ID NO 20, and the use of such polypeptide for the manufacture of a vaccine.

公开(公告)号：EP1537418A2

公开(公告)日：2005-06-08

申请号：EP03794948.4

申请日：2003-08-27

申请人： Intercell AG

发明人： BUSCHLE, Michael ,  HABEL, Andre ,  KLADE, Christoph ,  MATTNER, Frank ,  OTAVA, Oleksandr ,  VYTVYTSKA, Oresta ,  ZAUNER, Wolfgang ,  ZINKE, Sandra ,  KIRLAPPOS, Helen

IPC分类号： G01N33/576

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/525 ,  A61K2039/57 ,  C07K7/08 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/16122 ,  C12N2760/16122 ,  C12N2770/24222 ,  C12N2770/24234 ,  G01N2500/04 ,  Y10S930/223

摘要： Described is a method for isolating Hepatitis C Virus peptides (HPs) which have a binding capacity to a MHC/HLA molecule or a complex comprising said HCV-peptide and said MHC/HLA molecule characterized by the following steps: - providing a pool of HCV-peptide, said pool containing HCV-peptides which bind to said MHC/HLA molecules and HCV-peptides which do not bind to said MHC/HLA molecule, -contacting said MHC/HLA molecule with said pool of HCV-peptides whereby a HCV-peptide which has a binding capacity to said MHC/HLA molecule binds to said MHC/HLA molecule and a complex comprising said HCV-peptide and said MHC/HLA molecule is formed, -detecting and optionally separating said complex from the HCV-peptide which do not bind to said MHC/HLA molecule and optionally isolating and characterising the HCV-peptide from said complex.

公开(公告)号：EP2511291A2

公开(公告)日：2012-10-17

申请号：EP12164042.9

申请日：2008-06-13

申请人： Intercell AG

发明人： Meinke, Andreas ,  Nagy, Eszter ,  Noiges, Birgit ,  Von Gabain, Alexander ,  Asklin, Johanna

IPC分类号： C07K14/295

CPC分类号： C07K14/295 ,  A61K39/118 ,  G01N33/56927 ,  G01N2469/20

摘要： The present invention relates to isolated nucleic acid molecules which encode an antigen from a Chlamydia species, a vector which comprises such nucleic acid molecule, and a host cell comprising such vector. Furthermore, the invention provides antigens from a Chlamydia species, as well as fragments and variants thereof, a process for producing such antigens, and a process for producing a cell, which expresses such antigen. More specifically such antigens are produced by or associated with bacterial infections caused by Chlamydia pneumoniae. Moreover, the present invention provides antibodies binding to such antigen, a hybridoma cell producing such antibodies, methods for producing such antibodies, a pharmaceutical composition comprising such nucleic acid molecule, antigen, vector or antibody, the use of such nucleic acid molecule, antigen, vector or antibody for the preparation of a pharmaceutical composition, methods for identifying an antagonist capable of binding such antigen or of reducing or inhibiting the interaction activity of such antigen, methods for diagnosing an infection with Chlamydia and methods for the treatment or prevention of an infection with Chlamydia.

摘要翻译： 本发明涉及编码来自衣原体物种的抗原的分离的核酸分子，包含该核酸分子的载体和包含该载体的宿主细胞。 此外，本发明提供了来自衣原体物种的抗原，以及其片段和变体，产生此类抗原的方法，以及表达该抗原的细胞的制备方法。 更具体地，这种抗原由肺炎衣原体引起的细菌感染产生或与其相关。 此外，本发明提供了与这种抗原结合的抗体，产生此类抗体的杂交瘤细胞，产生此类抗体的方法，包含该核酸分子，抗原，载体或抗体的药物组合物，使用此类核酸分子，抗原， 用于制备药物组合物的载体或抗体，用于鉴定能够结合此类抗原的拮抗剂或降低或抑制此类抗原的相互作用活性的方法，用于诊断衣原体感染的方法以及用于治疗或预防感染的方法 与衣原体。

公开(公告)号：EP2275435A3

公开(公告)日：2011-08-31

申请号：EP10178861.0

申请日：2004-05-06

申请人： Intercell AG

发明人： Meinke, Andreas ,  Nagy, Eszter ,  Hanner, Markus ,  Horky, Markus ,  Kallenda, Sabine ,  Prustomersky, Sonja

IPC分类号： C07K14/315 ,  A61K39/09 ,  C12N15/31 ,  C07K16/12 ,  C12Q1/68 ,  C12N15/11 ,  G01N33/50

CPC分类号： C07K16/1275 ,  C07K14/315 ,  C07K2317/00

摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. agalactiae, methods for isolating such antigens and specific uses thereof.

公开(公告)号：EP2336357A1

公开(公告)日：2011-06-22

申请号：EP10178910.5

申请日：2004-04-15

申请人： Intercell AG

发明人： Meinke, Andreas ,  Nagy, Eszter ,  Hanner, Markus ,  Dewasthaly, Shailesh ,  Stierschneider, Ulrike

IPC分类号： C12Q1/68 ,  C07K14/31

CPC分类号： C07K14/3156 ,  A61K39/00 ,  A61K39/092 ,  C12Q1/689 ,  C12Q2600/158

摘要： The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments thereof from S. pneumoniae, methods for isolating such antigens and specific uses thereof.

公开(公告)号：EP2314603A3

公开(公告)日：2011-05-18

申请号：EP10010866.1

申请日：2003-10-15

申请人： Intercell AG

发明人： Reinscheid, Dieter J. ,  Boisvert, Heike ,  Schubert, Axel ,  Eikmanns, Bernhard ,  Meinke, Andreas

IPC分类号： C07K14/315

CPC分类号： C07K14/315 ,  A61K39/00

摘要： The present invention is related to nucleic acids coding for adhesion factors of group B streptococcus, adhesion factors of group B streptococcus and uses thereof. More particularly, the present invention is related to a polypeptide being such adhesion factors and comprising an amino acid sequence, whereby the amino acid sequence is SEQ ID NO 18, and the use of such polypeptide for the manufacture of a vaccine.

公开(公告)号：EP2292648A2

公开(公告)日：2011-03-09

申请号：EP10011209.3

申请日：2007-07-06

申请人： Intercell AG

发明人： Meinke, Andreas ,  Nagy, Eszter ,  Von Gabain, Alexander ,  Berger, Manfred ,  Tschanun, Beatrice ,  Schunn, Michael

IPC分类号： C07K14/315

CPC分类号： C07K14/315 ,  A61K39/00

摘要： The present invention relates to a peptide consisting of one antigen of Streptococcus pyogenes ( S. pyogenes ) of SEQ ID NO: 132 or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a S. pyogenes infection; a method for identifying a ligand capable of binding to said peptide; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

摘要翻译： 本发明涉及由SEQ ID NO：132的化脓性链球菌（Streptococcus pyogenes）（化脓性链球菌）的一种抗原或其功能活性变体组成的肽，任选地还包含另外的氨基酸残基; 编码该核酸的核酸; 包含所述肽或所述核酸的药物组合物，特别是疫苗; 与抗原特异性结合的抗体或功能活性片段; 产生所述抗体的杂交瘤细胞系; 一种生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制备用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 诊断化脓性链球菌感染的方法; 用于鉴定能够结合所述肽的配体的方法; 以及所述肽用于分离和/或纯化和/或鉴定该肽的相互作用配偶体的用途。

公开(公告)号：EP2292645A2

公开(公告)日：2011-03-09

申请号：EP10010868.7

申请日：2007-07-06

申请人： Intercell AG

发明人： Meinke, Andreas ,  Nagy, Eszter ,  Von Gabain, Alexander ,  Berger, Manfred ,  Tschanun, Beatrice ,  Schunn, Michael

IPC分类号： C07K14/315

CPC分类号： C07K14/315 ,  A61K39/00

摘要： The present invention relates to a peptide consisting of one antigen of Streptococcus pyogenes ( S. pyogenes ) of SEQ ID NO: 1 or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a S. pyogenes infection; a method for identifying a ligand capable of binding to said peptide; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

摘要翻译： 本发明涉及由SEQ ID NO：1的化脓性链球菌（Streptococcus pyogenes）（化脓性链球菌）的一种抗原或其功能活性变体组成的肽，任选地还包含另外的氨基酸残基; 编码该核酸的核酸; 包含所述肽或所述核酸的药物组合物，特别是疫苗; 与抗原特异性结合的抗体或功能活性片段; 产生所述抗体的杂交瘤细胞系; 一种生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制备用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 诊断化脓性链球菌感染的方法; 用于鉴定能够结合所述肽的配体的方法; 以及所述肽用于分离和/或纯化和/或鉴定该肽的相互作用配偶体的用途。

公开(公告)号：EP2292644A2

公开(公告)日：2011-03-09

申请号：EP10010865.3

申请日：2007-07-06

申请人： Intercell AG

发明人： Meinke, Andreas ,  Nagy, Eszter ,  Von Gabain, Alexander ,  Berger, Manfred ,  Tschanun, Beatrice ,  Schunn, Michael

IPC分类号： C07K14/315

CPC分类号： C07K14/315 ,  A61K39/00

摘要： The present invention relates to a peptide consisting of one antigen of Streptococcus pyogenes ( S. pyogenes ) of SEQ ID NO: 10 or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a S. pyogenes infection; a method for identifying a ligand capable of binding to said peptide; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

摘要翻译： 本发明涉及由SEQ ID NO：10的化脓性链球菌（化脓链球菌）的一种抗原或其功能活性变体组成的肽，其任选进一步由另外的氨基酸残基组成; 编码它的核酸; 包含所述肽或所述核酸的药物组合物，特别是疫苗; 特异性结合抗原的抗体或其功能活性片段; 产生所述抗体的杂交瘤细胞系; 生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制造用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 诊断化脓性链球菌感染的方法; 鉴定能够结合所述肽的配体的方法; 以及所述肽用于肽的相互作用配偶体的分离和/或纯化和/或鉴定的用途。