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    COMPOSITIONS AND METHODS FOR DETECTING C. JEJUNI AND AT LEAST ONE OF SALMONELLA, C. COLI, SHIGELLA, AND STEC
    3.
    发明公开
    COMPOSITIONS AND METHODS FOR DETECTING C. JEJUNI AND AT LEAST ONE OF SALMONELLA, C. COLI, SHIGELLA, AND STEC 审中-实审

    公开(公告)号：EP4382620A3

    公开(公告)日：2024-08-07

    申请号：EP24163934.3

    申请日：2022-07-26

    申请人： Gen-Probe Incorporated

    发明人： PANUGANTI, Sree Divya

    IPC分类号： C12Q1/689

    CPC分类号： C12Q1/689 ,  C12Q1/686 ,  Y02A50/30 ,  C12Q2600/1620130101

    摘要： There is described a set of oligonucleotides for determining the presence or absence of at least two enteric pathogens, said set of oligonucleotides comprising (a) and at least one of (b)-(e): (a) a C. jejuni-specific amplification oligomer set comprising first and second oligomers respectively comprising target-hybridizing sequences consisting of the nucleotide sequences of: SEQ ID NO:11 and SEQ ID NO:19; (b) a Salmonella-specific amplification oligomer set comprising first and second oligomers respectively comprising target-hybridizing sequences consisting of the nucleotide sequences of: (i) SEQ ID NO:12 and SEQ ID NO:14; (ii) SEQ ID NO:21 and SEQ ID NO:47; (iii) SEQ ID NO:38 and SEQ ID NO:36; (iv) SEQ ID NO:35 and SEQ ID NO:40; (v) SEQ ID NO:12 and SEQ ID NO:28; (vi) SEQ ID NO:42 and SEQ ID NO:31; or (vii) SEQ ID NO:41 and SEQ ID NO:27; (c) a C. coli-specific amplification oligomer set comprising first and second oligomers respectively comprising target-hybridizing sequences consisting of the nucleotide sequences of: (i) SEQ ID NO:8 and SEQ ID NO:10; (d) a Shigella-specific amplification oligomer set comprising first and second oligomers respectively comprising target-hybridizing sequences consisting of the nucleotide sequences of: (i) SEQ ID NO:15 and SEQ ID NO:17; (ii) SEQ ID NO:34 and SEQ ID NO:22; or (iii) SEQ ID NO:32 and SEQ ID NO:33; and (e)a Shigatoxigenic E. coli (STEC)-specific amplification oligomer set comprising first and second oligomers respectively comprising target-hybridizing sequences consisting of the nucleotide sequences of: (i) SEQ ID NO:20 and SEQ ID NO:3; (ii) SEQ ID NO:49 and SEQ ID NO:3; or (iii) SEQ ID NOT and SEQ ID NO:7.

    COMPOSITIONS AND METHODS FOR DETECTING GROUP A STREPTOCOCCUS
    4.
    发明公开
    COMPOSITIONS AND METHODS FOR DETECTING GROUP A STREPTOCOCCUS 审中-实审

    公开(公告)号：EP4407046A2

    公开(公告)日：2024-07-31

    申请号：EP24172440.0

    申请日：2020-03-20

    申请人： Gen-Probe Incorporated

    发明人： PANUGANTI, Sree Divya ,  SHAH, Ankur

    IPC分类号： C12Q1/689

    CPC分类号： C12Q1/689

    摘要： There is described a composition or kit comprising at least first and second amplification oligomers, wherein:(a) the first amplification oligomer and second amplification oligomer are configured to amplify a Group A Streptococcus amplicon; (b) the first amplification oligomer: (i) comprises a first sequence which is SEQ ID NO: 4; (ii) comprises a sequence with 0, 1, or 2 mismatches to a first sequence which is SEQ ID NO: 4; (iii) competes for hybridization to a Group A Streptococcus (GAS) nucleic acid under stringent conditions with an amplification oligomer whose sequence consists of a first sequence which is SEQ ID NO: 4; or (iv) comprises at least 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 contiguous nucleotides of a first sequence which is SEQ ID NO: 4; and (c) the second amplification oligomer: (i) comprises a second sequence which is SEQ ID NO: 6; (ii) comprises a sequence with 0, 1, or 2 mismatches to a second sequence which is SEQ ID NO: 6; (iii) competes for hybridization to a Group A Streptococcus (GAS) nucleic acid under stringent conditions with an amplification oligomer whose sequence consists of a second sequence which is SEQ ID NO: 6; or (iv) comprises at least 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 contiguous nucleotides of a second sequence which is SEQ ID NO: 6.

    NUCLEIC ACID DETECTION REAGENT AND DETECTION METHOD FOR MYCOBACTERIUM TUBERCULOSIS
    5.
    发明公开
    NUCLEIC ACID DETECTION REAGENT AND DETECTION METHOD FOR MYCOBACTERIUM TUBERCULOSIS 审中-实审

    公开(公告)号：EP4403650A1

    公开(公告)日：2024-07-24

    申请号：EP23156490.7

    申请日：2023-02-14

    申请人： Anbio Biotechnology Limited ,  Wang, Jincheng

    发明人： WANG, Daming ,  WANG, Jincheng

    IPC分类号： C12Q1/689 ,  C12Q1/6844

    CPC分类号： C12Q1/689 ,  C12Q2600/15820130101 ,  C12Q1/6844

    摘要： The present application provides a nucleic acid detection reagent and detection method for Mycobacterium tuberculosis, comprising: Tris-HCL, MgCl2, UNG enzyme, Bst DNA polymerase, reverse transcriptase, trehalose, sucrose, mannitol, Tween 20, guanidine hydrochloride and the primers of six kinds of Mycobacterium tuberculosis, the primers of six kinds of Mycobacterium tuberculosis are TB-F3, TB-R3, TB-FIP, TB-BIP, TB-LF and TB-LB, wherein TB is tuberculosis branch bacilli. In the embodiment of the present application, the nucleic acid detection reagent can be used to perform a one-step detection method for the nucleic acid (DNA or RNA) of pathogens present in throat swabs, nasal swabs, saliva, etc., thereby realizing a convenient, efficient and rapid detection, to achieve the sample in, the result out.