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公开(公告)号：EP2621945B1
公开(公告)日：2018-04-11
申请号：EP11833072.9
申请日：2011-09-28
申请人： NoNO Inc.
CPC分类号： C07K14/00 , A61K38/00 , C07K7/06 , C07K2319/10 , C07K2319/22 , C07K2319/23 , C12N9/0036 , C12Y106/05003
摘要： The invention is based in part on identifying a core region of ND2 responsible for interacting with Src to within residues 289-321 of ND2 and more particularly residues 307-321 or 310-321 of ND2. Peptides including, overlapping or from within this region can be used to inhibit ND2 interaction with Src Inhibition of this interaction is useful for treatment or prophylaxis of neurological diseases and disorders, pain and cancer.
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公开(公告)号：EP3149048A4
公开(公告)日：2018-01-03
申请号：EP15799583
申请日：2015-05-28
申请人： NONO INC
CPC分类号： A61K38/162 , A61K9/0019 , A61K9/19 , A61K38/00 , A61K47/12 , A61K47/183 , A61K47/26 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/16 , C07K14/163 , C07K14/705 , C07K19/00 , C12N2740/16322
摘要： The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c, as chloride salts. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. The chloride salt of TAT-NR2B9c shows improved stability compared with the acetate salt form of prior formulations. Formulations of the chloride salt of TAT-NR2B9c are stable at ambient temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.
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23.发明公开
公开(公告)号：EP3148568A1
公开(公告)日：2017-04-05
申请号：EP15800695.7
申请日：2015-05-28
申请人： Nono Inc.
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/00 , A61K38/10 , A61K47/183 , A61K47/26 , C07K14/16 , C07K14/70571 , C07K2319/10
摘要： The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c including histidine, trehalose and lysine. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. Such formulations are stable at ambient temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.
摘要翻译： 本发明提供了活性剂的冻干制剂，特别是包含组氨酸，海藻糖和赖氨酸的TAT-NR2B9c的冻干制剂。 TAT-NR2B9c显示了治疗中风，动脉瘤，蛛网膜下腔出血和其他神经或神经外伤的前景。 这样的制剂在环境温度下是稳定的，因此有助于在救护车中维持这种制剂的供应，以用于在疾病或事故现场或在医院过境中的施用。
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公开(公告)号：EP2925338A1
公开(公告)日：2015-10-07
申请号：EP13859059.1
申请日：2013-11-25
申请人： Nono Inc.
CPC分类号： A61K38/10 , A61K9/0019 , A61K9/19 , A61K38/177 , A61K47/183 , A61K47/26
摘要： The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. Such formulations are stable at room temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.
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25.发明公开CO-ADMINISTRATION OF AN AGENT LINKED TO AN INTERNALIZATION PEPTIDE WITH AN ANTI-INFLAMMATORY 审中-公开共施用WITH A INTERNALISIERUNGSPEPTID补救和抗炎药联
公开(公告)号：EP2440231A4
公开(公告)日：2013-04-24
申请号：EP10786870
申请日：2010-06-10
申请人： NONO INC
CPC分类号： A61K47/48315 , A61K31/275 , A61K31/277 , A61K38/08 , A61K38/10 , A61K45/06 , A61K47/645 , A61K2300/00
摘要： The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.
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27.发明公开MODEL SYSTEMS AND TREATMENT REGIMES FOR TREATMENT OF NEUROLOGICAL DISEASE 审中-公开模型系统和治疗可用于治疗神经系统疾病方法
公开(公告)号：EP2440230A2
公开(公告)日：2012-04-18
申请号：EP10786859.8
申请日：2010-06-10
申请人： Nono, Inc.
摘要： The invention provides animal models and clinical trials for assessing agents for potential use in treating and effecting prophylaxis stroke and other neurological diseases, particularly those mediated at least in part by excitoxitity. The invention also provides preferred dosage and infusion regimes and pharmaceutical compositions for clinical application of such agents.
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公开(公告)号：EP2723363B1
公开(公告)日：2018-08-29
申请号：EP12802409.8
申请日：2012-06-23
申请人： NoNO Inc.
发明人： TYMIANSKI, Michael
CPC分类号： A61K38/10 , A61K38/1787 , A61K38/49 , A61K2300/00
摘要： The invention provides a combination treatment for ischemia conditions in or otherwise affecting the CNS, such as stroke. The treatment invoices administration of a PSD-95 inhibitor and performing reperfusion therapy (e.g. by administration of tPA). Administration a PSD-95 inhibitor in combination with reperfusion therapy increases the efficacy of the reperfusion therapy and/or slows the decline in efficacy of reperfusion therapy with time after onset of ischemia thus extending the window in which reperfusion therapy can be administered.
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公开(公告)号：EP3149048A1
公开(公告)日：2017-04-05
申请号：EP15799583.8
申请日：2015-05-28
申请人： Nono Inc.
CPC分类号： A61K38/162 , A61K9/0019 , A61K9/19 , A61K38/00 , A61K38/10 , A61K47/12 , A61K47/183 , A61K47/26 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/16 , C07K14/163 , C07K14/705 , C07K19/00 , C12N2740/16322
摘要： The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c, as chloride salts. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. The chloride salt of TAT-NR2B9c shows improved stability compared with the acetate salt form of prior formulations. Formulations of the chloride salt of TAT-NR2B9c are stable at ambient temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.
摘要翻译： 本发明提供活性剂，特别是作为氯化物盐的TAT-NR2B9c的冻干制剂。 TAT-NR2B9c已经显示出治疗中风，动脉瘤，蛛网膜下腔出血以及其他神经或神经功能障碍的前景。 与先前制剂的乙酸盐形式相比，TAT-NR2B9c的氯化物盐显示出改进的稳定性。 TAT-NR2B9c的氯化物盐的配方在环境温度下是稳定的，因此有助于维护在救护车上的这种制剂的供应，以便在疾病或意外现场进行管理或者转运到医院。
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