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    BIOSENSOR SYSTEM FOR THE RAPID DETECTION OF ANALYTES
    1.
    发明公开
    BIOSENSOR SYSTEM FOR THE RAPID DETECTION OF ANALYTES 审中-公开

    公开(公告)号：EP3404411A2

    公开(公告)日：2018-11-21

    申请号：EP18180724.9

    申请日：2016-03-31

    申请人： Fundamental Solutions Corporation

    发明人： ZENG, Lingchun ,  ZUPANCIC, Thomas, J. ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

    IPC分类号： G01N33/554

    CPC分类号： C07K14/70535 ,  C07K14/7051 ,  C07K2319/00 ,  C07K2319/22 ,  G01N33/554 ,  G01N33/56911 ,  G01N33/56983

    摘要： A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.

    COMPOSITIONS COMPRISING NATRIURETIC PEPTIDES AND METHODS OF USE THEREOF
    4.
    发明授权
    COMPOSITIONS COMPRISING NATRIURETIC PEPTIDES AND METHODS OF USE THEREOF 有权
    包含NATRIURETIC肽的组合物及其使用方法

    公开(公告)号：EP2658979B1

    公开(公告)日：2018-02-14

    申请号：EP11853820.6

    申请日：2011-12-23

    申请人： Alexion Pharmaceuticals, Inc.

    发明人： CRINE, Philippe ,  JOUBERT, Simon ,  PARAT, Marie

    IPC分类号： C12N15/16 ,  A61K38/17 ,  A61P19/08 ,  C07K14/575 ,  C07K19/00 ,  C12N15/62

    CPC分类号： C07K14/58 ,  A61K31/7088 ,  A61K38/2242 ,  C07K2319/22 ,  C07K2319/30 ,  C07K2319/31

    摘要： The present invention provides methods, compositions, and kits for the treatment of disorders associated with overactivation of FGFR3, such as achondroplasia; bone or cartilage disorders; or vascular smooth muscle disorders, or for the elongation of bone. In some embodiments, the present invention provides polypeptides having a natriuretic peptide fused to an Fc domain of an immunoglobulin. Such polypeptides can be administered to subjects, e.g., subcutaneously, to treat a disorder associated with overactivation of FGFR3, a bone or cartilage disorder, or a vascular smooth muscle disorder, or to elongate bone. The invention also features nucleic acid molecules encoding such polypeptides and the use of the nucleic acid molecules for treating disorders associated with overactivation of FGFR3, bone or cartilage disorders, or vascular smooth muscle disorders, or for elongating bone.

    BIOSENSOR SYSTEM FOR THE RAPID DETECTION OF ANALYTES
    5.
    发明公开
    BIOSENSOR SYSTEM FOR THE RAPID DETECTION OF ANALYTES 审中-公开
    生物传感器系统快速检测分析

    公开(公告)号：EP3277831A2

    公开(公告)日：2018-02-07

    申请号：EP16774179.2

    申请日：2016-03-31

    申请人： Fundamental Solutions Corporation

    发明人： ZUPANCIC, Thomas, J. ,  ZENG, Lingchun ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

    IPC分类号： C12Q1/04 ,  G01N33/554 ,  G01N33/569

    CPC分类号： C07K14/70535 ,  C07K14/7051 ,  C07K2319/00 ,  C07K2319/22 ,  G01N33/554 ,  G01N33/56911 ,  G01N33/56983

    摘要： A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.

    NEW BACTERIOPHAGE ADHESION PROTEINS
    10.
    发明公开
    NEW BACTERIOPHAGE ADHESION PROTEINS 审中-公开
    新的细菌粘附蛋白

    公开(公告)号：EP3124492A1

    公开(公告)日：2017-02-01

    申请号：EP16188008.3

    申请日：2009-07-03

    申请人： bioMérieux S.A.

    发明人： BIEBL, Manfred ,  GRASSL, Renate ,  WALTER, Monika ,  MILLER, Stefan

    IPC分类号： C07K14/005 ,  G01N33/569

    CPC分类号： C07K14/005 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/40 ,  C12N2700/00 ,  C12N2795/10322 ,  G01N33/56911 ,  G01N2333/005

    摘要： The present invention relates to bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysacchaiides. The invention further relates to nucleic acid molecules comprising a sequence encoding the proteins according to the present invention. In addition, the present invention relates to a method for generating bacteriophage adhesion proteins according to the present invention. The invention further relates to the use of said proteins and methods of detection, purification and enrichment of bacteria.

    摘要翻译： 本发明涉及与革兰氏阴性菌的O-抗原结合的噬菌体粘附蛋白，其缺乏结合噬菌体和水解脂多糖的能力。 本发明进一步涉及包含编码根据本发明的蛋白质的序列的核酸分子。 此外，本发明涉及根据本发明的产生噬菌体粘附蛋白的方法。 本发明进一步涉及所述蛋白质的用途以及检测，纯化和富集细菌的方法。