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    COMPOSITION FOR IMAGING ATHEROSCLEROSIS AND METHOD FOR DIAGNOSING ATHEROSCLEROSIS BY USING SAME
    25.
    发明公开
    COMPOSITION FOR IMAGING ATHEROSCLEROSIS AND METHOD FOR DIAGNOSING ATHEROSCLEROSIS BY USING SAME 审中-公开
    组成动脉粥样硬化和方法，动脉粥样硬化，以便诊断成像

    公开(公告)号：EP3108901A1

    公开(公告)日：2016-12-28

    申请号：EP15752671.6

    申请日：2015-02-17

    申请人： Korea University Research and Business Foundation ,  Seoul National University R & DB Foundation

    发明人： SEO, Hong Seog ,  KIM, Sungeun ,  KIM, Eung Ju ,  JEONG, Jae Min

    IPC分类号： A61K51/04 ,  A61K49/06 ,  A61K51/02 ,  A61P9/10

    CPC分类号： A61K51/081 ,  A61K51/04 ,  A61K51/044 ,  A61K51/048 ,  A61K51/0482 ,  A61K51/0491

    摘要： The present disclosure relates to a composition for imaging atherosclerosis and a method for diagnosing atherosclerosis using the same. The composition for imaging atherosclerosis according to the present disclosure shows excellent atherosclerosis diagnosis accuracy, enables diagnosis of atherosclerosis even for a person with diseases of glucose metabolism such as diabetes and enables effective diagnosis even for atherosclerosis occurring in the brain and heart. In addition, manufacturing cost is low compared with the existing imaging composition for diagnosis of atherosclerosis. Therefore, atherosclerosis can be effectively diagnosed by using the same.

    摘要翻译： 本发明涉及一种用于成像动脉粥样硬化的组合物和用于使用相同的诊断动脉粥样硬化的方法。 动脉粥样硬化gemäß成像本公开的组合物显示出优异的动脉粥样硬化的诊断精确度，动脉粥样硬化启用诊断即使对于葡萄糖代谢的疾病的人：如糖尿病和启用有效的诊断即使对于动脉粥样硬化在大脑和心脏发生的。 另外，制造成本低与动脉粥样硬化的诊断现有成像组合物相比。 因此，动脉粥样硬化可以通过有效地使用相同的诊断。

    Technetium-99m radiolabelled diethylene triamine pentaacetic acid diester and process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester
    27.
    发明公开
    Technetium-99m radiolabelled diethylene triamine pentaacetic acid diester and process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester 失效
    Technetium-99m markierteDiäthylentriaminpentaessigsäure-Diester und Verfahren zu deren Herstellung

    公开(公告)号：EP0953360A1

    公开(公告)日：1999-11-03

    申请号：EP98250102.5

    申请日：1998-03-24

    申请人： Council of Scientific and Industrial Research

    发明人： Chatterjee, Mita ,  Sen, Karabi ,  Banerjee, Some Nath

    IPC分类号： A61K51/04

    CPC分类号： A61K51/048

    摘要： The present invention relates a technetium-99m radiolabelled diethylene triamine pentaacetic acid diester kit for the diagnosis of renal disorders.
    Accordingly, the present invention provides a technetium-99m radiolabelled diethylene triamine pentaacetic acid diester kit for the diagnosis of renal disorders wherein technetium-99m diethylene triamine pentaacetic acid dimethyl ester has Rf value = zero in silica gel / acetone TLC system and Rf value = 1 in silica gel / acetonitrile water (1:1) TLC system and technecium-99m diethylene triamine pentaacetic acid dimethyl ester movement is of the order of half of the distance as compared to the standard compound (technecium-99m diethylene triamine pentaacetic acid) on conducting paper electrophoresis.
    The process for the preparation of a technetium-99m radiolabelled diethylene triamine pentaacetic acid diester kit for the diagnosis of renal disorders comprises:

    (a) Adding appropriate amount of stannous ion to a dilute aqueous solution of diethylene triamine pentaacetic diester prepared by known methods
    (b) Keeping the resultant solution abtained in step (a) in an evacuated rubber sealed injection vial flushed with nitrogen;
    (c) lyophilising the said kit and storing the lyophilised product an obtained in step (b) at 4°C;
    (d) radiolabelling the said lyophilised product with Tc-99m by allowing the kit to attain the room temparature before addition of 99m TcO 4 ;
    (e) shaking the kit vigorously to obtain the radiolabelled product available for use within a period of an hour.

    摘要翻译： 本发明涉及锝-99m放射性标记的二亚乙基三胺五乙酸二酯试剂盒，用于诊断肾脏疾病。 因此，本发明提供了用于诊断肾脏疾病的锝-99m放射性标记的二亚乙基三胺五乙酸二酯试剂盒，其中锝-99m二亚乙基三胺五乙酸二甲酯在硅胶/丙酮TLC系统中的Rf值= 0，Rf值= 1 在硅胶/乙腈水（1:1）中，TLC系统和技术99m二亚乙基三胺五乙酸二甲酯的运动与标准化合物（technecium-99m二亚乙基三胺五乙酸）相比，传导距离的一半是导电 纸电泳。 用于制备用于诊断肾脏疾病的锝-99m放射性标记的二亚乙基三胺五乙酸二酯试剂盒的方法包括：（a）通过已知方法（b）制备的二亚乙基三胺五乙酸二酯的稀二水溶液中加入适量的亚锡离子 ）在用氮气冲洗的抽真空的橡胶密封注射小瓶中，使步骤（a）中保持所得溶液; （c）将所述试剂盒冻干，并将步骤（b）中获得的冻干产品在4℃下储存; （d）通过允许试剂盒在加入99m TcO 4之前达到室温，用Tc-99m放射性标记所述冻干产物; （e）大力摇动试剂盒，以获得可在一小时内使用的放射性标记产品。