公开(公告)号：EP3400085A1

公开(公告)日：2018-11-14

申请号：EP16826752.4

申请日：2016-12-29

Applicant: Bayer AS

Inventor： MANTZILAS, Dimitrios ,  KARLSON, Jan Roger ,  ØSTBY, Judit Tjelmeland ,  FRENVIK, Janne Olsen

IPC: B01D15/36 ,  A61K51/06 ,  A61K51/12 ,  B01J41/05

CPC classification number: B01D15/363 ,  A61K51/0478 ,  A61K51/065 ,  A61K51/1093 ,  A61K51/1282 ,  B01J41/05 ,  B01J49/60

Abstract: The present invention provides a method for the purification of 227Th from a mixture comprising 227Th and 223Ra, said method comprising: i) preparing a first solution comprising a mixture of 227Th and 223Ra ions dissolved in an aqueous solution of first mineral acid; ii) loading said first solution onto a strong base anion exchange resin; iii) eluting 223Ra from said strong base anion exchange resin using a second mineral acid in an aqueous solution; iv) optionally rinsing said strong base anion exchange resin using a first aqueous medium; v) eluting 227Th from said strong base anion exchange resin using a third mineral acid in an aqueous solution whereby to generate a second solution comprising 227Th. The invention further provides a purified 227Th solution, a corresponding pharmaceutical formulation and methods of treatment of neoplastic disease.

公开(公告)号：EP2673257B1

公开(公告)日：2018-07-18

申请号：EP12744282.0

申请日：2012-02-10

Applicant: Washington University

Inventor： SHARMA, Vijay ,  SIVAPACKIAM, Jothilingam ,  PIWNICA-WORMS, David

IPC: C07C211/49 ,  C07F5/00 ,  C05D9/00

CPC classification number: A61K51/0478 ,  C05D9/02 ,  C07B59/001 ,  C07B59/002 ,  C07C251/24 ,  C07F5/003

Abstract: Tracers that can be used for PET or SPECT imaging of the distribution of Pgp are disclosed. The tracers are metalloprobes that can comprise a radioactive metal ion such as 67Ga or 68Ga. Methods of synthesizing the tracers, and methods of imaging heart and other tissues are also disclosed. The tracers can be used to obtain high signal-to-background ratios for imaging tissues in vivo such as heart or tumor tissue. In various embodiments, disclosed tracers can exhibit, a) enhanced first pass extraction into heart tissue compared to presently available probes, b) linearity with true blood flow, c) enhanced detection of myocardial viability compared to presently available probes, d) reduced liver retention compared to presently available probes, and e) more efficient clearance from non-cardiac and adjoining tissues compared to presently available probes.

公开(公告)号：EP2533817B1

公开(公告)日：2018-03-28

申请号：EP11702857.1

申请日：2011-02-14

Applicant: Bayer AS

Inventor： RAMDAHL, Thomas

IPC: A61K51/10 ,  A61K51/04 ,  A61P35/00

CPC classification number: A61K51/0478 ,  A61K51/1045 ,  A61K51/1051 ,  A61K51/1072 ,  A61K51/1093 ,  A61P35/00

Abstract: The present invention provides a tissue-targeting complex comprising a tissue targeting moiety, an octadentate hydroxypyridinone-containing ligand and the ion of an alpha-emitting thorium radionuclide. The invention additionally provides therapeutic methods employing such complexes, methods of their production and use, and kits and pharmaceutical compositions comprising such complexes.

公开(公告)号：EP3265134A2

公开(公告)日：2018-01-10

申请号：EP16762295.0

申请日：2016-03-07

Applicant: Mayo Foundation for Medical Education and Research

Inventor： BANSAL, Aditya ,  DEGRADO, Timothy, R. ,  PANDEY, Mukesh, K.

IPC: A61K51/04 ,  A61K49/12

CPC classification number: A61K51/0478 ,  A61K49/103 ,  A61K49/106 ,  A61K49/1896 ,  A61K51/1203

Abstract: Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89Zr-Desferrioxamine-NCS labeling agent.

公开(公告)号：EP2838880A4

公开(公告)日：2015-12-09

申请号：EP13778788

申请日：2013-04-17

Applicant: MERRIMACK PHARMACEUTICALS INC

Inventor： DRUMMOND DARYL C ,  KIRPOTIN DMITIRI B ,  WICKHAM THOMAS ,  HENDRIKS BART S ,  AGRESTA SAMUEL ,  LEE HELEN

IPC: C07C337/08 ,  A61K51/04 ,  A61K51/12

CPC classification number: A61K51/0478 ,  A61K9/1271 ,  A61K31/4745 ,  A61K31/704 ,  A61K51/1234 ,  C07C337/08

Abstract: The present invention relates to a novel composition useful in targeted diagnostic and/or therapy of a target site, such as cancerous tissue. The composition and methods disclosed herein find particular use in diagnosing and imaging cancerous tissue. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.

Abstract translation: 本发明涉及可用于目标部位如癌组织的靶向诊断和/或治疗的新型组合物。 本文公开的组合物和方法在诊断和成像癌组织中特别有用。 本发明提供了一种用于正电子发射断层摄影（PET）成像技术的新诊断工具。

公开(公告)号：EP2800471A4

公开(公告)日：2015-11-04

申请号：EP13733617

申请日：2013-01-04

Applicant: MOLECULAR INSIGHT PHARM INC

Inventor： BABIC JOHN W ,  ZIMMERMAN CRAIG ,  JOYAL JOHN ,  LU SHAWN ,  HILLIGER SHAWN ,  MARESCA KEVIN P ,  MARQUIS JOHN

IPC: C07D233/64 ,  A61K51/04 ,  C07F13/00

CPC classification number: C07D249/04 ,  A61K51/0453 ,  A61K51/0478 ,  C07D233/00 ,  C07D233/64 ,  C07D403/12 ,  C07D417/12 ,  C07F13/00 ,  C07F13/005

Abstract: The present invention is directed to CA IX inhibitors that conform to Formula I where the substituents X, A, B, D, E, E′ and G are as defined above. Also described are Pt, 64Cu, 186Re, 188Re and 99mTc metal complexes of Formula I compounds which find use as candidate agents for imaging tumors.

公开(公告)号：EP2440584A4

公开(公告)日：2015-09-23

申请号：EP10786957

申请日：2010-06-13

Applicant: HARVARD COLLEGE

Inventor： MAHMOOD ASHFAQ ,  JONES ALUN G ,  LIMPA-AMARA NAENGNOI ,  PENG YIJIE ,  AKGUN ZEYNEP

IPC: C08F4/44 ,  A61K49/00 ,  A61K51/02 ,  A61K51/04 ,  C07C319/00 ,  C07C323/41 ,  C07D211/14 ,  C07D211/22 ,  C07D213/36 ,  C07D333/20 ,  C07D401/12 ,  C07F13/00

CPC classification number: A61K49/0002 ,  A61K51/02 ,  A61K51/04 ,  A61K51/0478 ,  A61K2123/00 ,  C07C323/41 ,  C07C2602/10 ,  C07D211/14 ,  C07D211/22 ,  C07D213/36 ,  C07D333/20 ,  C07D401/12 ,  C07F13/005

公开(公告)号：EP2749295A1

公开(公告)日：2014-07-02

申请号：EP13199365.1

申请日：2013-12-23

Applicant: NIHON MEDI-PHYSICS CO., LTD. ,  National Institute of Radiological Sciences ,  National Cancer Center

Inventor： Yoshii, Yukie ,  Matsumoto, Hiroki ,  Yoshimoto, Mitsuyoshi

IPC: A61K51/04 ,  A61K31/195 ,  A61K31/555 ,  A61P35/00

CPC classification number: A61K51/0497 ,  A61K31/195 ,  A61K31/555 ,  A61K51/0478 ,  A61K2300/00

Abstract: A radiopharmaceutical comprising a particular radioactive dithiosemicarbazone copper complex, wherein the radiopharmaceutical is used for combined administration with a chelating agent, and wherein the chelating agent comprises a multidentate ligand having a maximum dentate number of 2 or more to 4 or less.

Abstract translation: 一种包含特定放射性二硫代缩氨基脲铜络合物的放射性药物，其中所述放射性药物用于与螯合剂组合施用，并且其中所述螯合剂包含最大齿数为2以上至4以下的多齿配体。

公开(公告)号：EP1968647B1

公开(公告)日：2013-10-16

申请号：EP06840896.2

申请日：2006-12-29

Applicant: Leibniz-Institut für Neurobiologie

Inventor： ZIABREVA, Iryna ,  HENRICH-NOACK, Petra ,  GOLDSCHMIDT, Jürgen ,  BALDAUF, Kathrin ,  SCHEICH, Henning ,  REYMANN, Klaus G. ,  SCHRÖDER, Ulrich H. ,  PFORTE, Claudia ,  RIEK-BURCHARDT, Monika

IPC: A61K49/00

CPC classification number: A61K49/0002 ,  A61K49/103 ,  A61K51/0476 ,  A61K51/0478

公开(公告)号：EP2598175A1

公开(公告)日：2013-06-05

申请号：EP11741553.9

申请日：2011-07-27

Applicant: GE Healthcare Limited

Inventor： BARNETT, David, Jonathan

IPC: A61K51/04

CPC classification number: A61K51/088 ,  A61K51/0478 ,  A61K51/082

Abstract: The present invention relates to 99mTc-maraciclatide radiopharmaceutical compositions, which are stabilised with a radioprotectant. Also described are kits for the preparation of the radiopharmaceutical compositions, as well methods of preparing such compositions from the kit. The invention also includes methods of imaging the mammalian body using the radiopharmaceutical compositions.