公开(公告)号：EP2721410A2

公开(公告)日：2014-04-23

申请号：EP12800484.3

申请日：2012-06-16

Applicant: Pitari, Giovanni, M. ,  Zuzga, David, S.

Inventor： Pitari, Giovanni, M. ,  Zuzga, David, S.

IPC: G01N33/53

CPC classification number: G01N33/57484 ,  G01N33/57446 ,  G01N2333/4712

Abstract: Disclosed herein are methods for diagnosing the state of an epithelial tumor or tissue in a subject. Also disclosed are methods of diagnosing tumor initiation in an epithelial tissue of a subject. Also disclosed are methods of determining prognosis of a subject with an epithelial tumor. These methods include, in part, measuring the amount of pSer239-VASP, pSerl57-VASP, and/or total VASP in a subject or in a tissue or tumor of a subject and comparing those levels to an appropriate reference level. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：EP2653546A2

公开(公告)日：2013-10-23

申请号：EP11849123.2

申请日：2011-12-13

Applicant: Samsung Life Public Welfare Foundation

Inventor： PAIK, Soon Myung ,  KIM, Sung ,  KANG, Won Ki ,  LEE, Jee Yun ,  BAE, Jae Moon ,  SOHN, Tae Sung ,  NOH, Jae Hyung ,  CHOI, Min Gew ,  PARK, Young Suk ,  PARK, Joon Oh ,  PARK, Se Hoon ,  LIM, Ho Yeong ,  JUNG, Sin Ho

IPC: C12N15/11 ,  G01N33/574 ,  C12Q1/68 ,  G01N33/68 ,  G06F17/10

CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57446 ,  G01N2800/52 ,  G06F19/34

Abstract: The present invention relates to a marker for predicting a gastric cancer prognosis, a composition and a kit for predicting gastric cancer prognosis comprising an agent for measuring the expression level thereof, and a method for predicting gastric cancer prognosis using the marker. According to the present invention, gastric cancer prognosis may be predicted promptly and accurately, and an appropriate treatment plan can be determined based on the predicted prognosis, which has an advantage of contributing to significant reduction of death caused by gastric cancer. Particularly, according to the present invention, the survival rate can be remarkably increased by using the treatment method for a stage III gastric cancer patient to a patient who has been predicted to have a negative prognosis among stage Ib/II gastric cancer patients.

Abstract translation: 本发明涉及用于预测胃癌预后的标记物，用于预测胃癌预后的组合物和试剂盒，其包含用于测量其表达水平的试剂，以及使用该标记物预测胃癌预后的方法。 根据本发明，可以及时，准确地预测胃癌预后，并且可以基于预测的预后来确定适当的治疗计划，其具有有助于显着降低由胃癌引起的死亡的优点。 特别地，根据本发明，通过对预期在Ib / II期胃癌患者中具有阴性预后的患者使用III期胃癌患者的治疗方法，可以显着提高存活率。

公开(公告)号：EP2544004A4

公开(公告)日：2013-07-31

申请号：EP11750735

申请日：2011-03-03

Applicant: TORAY INDUSTRIES ,  UNIV KYOTO

Inventor： KOBAYASHI MICHIMOTO ,  TANAKA YOSHINORI ,  KANAMORI SATOKO ,  JUNG GIMAN ,  SAKAI YOSHIHARU ,  OKABE HIROSHI

IPC: G01N33/574 ,  C07K14/47 ,  C07K16/18

CPC classification number: G01N33/57446 ,  C07K14/4702 ,  G01N33/57488

公开(公告)号：EP2065372B1

公开(公告)日：2012-11-28

申请号：EP07806561.2

申请日：2007-08-27

Applicant: Eisai R&D Management Co., Ltd.

Inventor： YAMAMOTO, Yuji ,  MATSUSHIMA, Tomohiro ,  TSURUOKA, Akihiko ,  OBAISHI, Hiroshi ,  NAKAGAWA, Takayuki

IPC: C07D215/22 ,  A61K31/47 ,  A61P35/00 ,  A61P43/00 ,  C12Q1/02 ,  C07D215/48 ,  G01N33/574

CPC classification number: C07D215/22 ,  A61K31/47 ,  C07D215/48 ,  G01N33/57446 ,  G01N2333/71 ,  G01N2800/52

公开(公告)号：EP2405269A4

公开(公告)日：2012-08-15

申请号：EP10748464

申请日：2010-02-23

Applicant: NAT INST OF ADVANCED IND SCIEN ,  UNIV TSUKUBA

Inventor： KUNO ATSUSHI ,  HIRABAYASHI JUN ,  MATSUDA ATSUSHI ,  NARIMATSU HISASHI ,  IKEHARA YUZURU ,  SHODA JUNICHI ,  KAWAMOTO TORU

IPC: G01N33/574 ,  G01N21/64 ,  G01N37/00

CPC classification number: G01N21/648 ,  G01N33/57407 ,  G01N33/57438 ,  G01N33/57446

公开(公告)号：EP2347261B1

公开(公告)日：2012-08-15

申请号：EP09795836.7

申请日：2009-11-20

Applicant: Biodesix Inc.

Inventor： RÖDER, Heinrich ,  TSYPIN, Maxim ,  GRIGORIEVA, Julia

IPC: G01N33/574 ,  G01N33/68

CPC classification number: G01N33/57446 ,  G01N33/6848 ,  G01N2800/52 ,  G06F19/707 ,  Y02A90/26 ,  Y10T436/24

Abstract: Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a colorectal cancer (CRC) patient is likely to benefit from a drug targeting an epidermal growth factor receptor pathway, such as monoclonal antibody EGFR inhibitors.

公开(公告)号：EP2435071A1

公开(公告)日：2012-04-04

申请号：EP10730108.7

申请日：2010-05-28

Applicant: F.Hoffmann-La Roche AG

Inventor： KIERMAIER, Astrid ,  PICKL, Marlene ,  RUESCHOFF, Josef

IPC: A61K39/00 ,  G01N33/574 ,  C12Q1/68

CPC classification number: G01N33/57446 ,  A61K2039/505 ,  C07K16/32 ,  C12Q1/6886 ,  C12Q2600/106

Abstract: The present invention relates to means and methods for the identification of responders for or a patient sensitive to a modulator of the HER2/neu (ErbB2) signaling pathway. Also described herein are corresponding methods of treatment of a group of patients determined and defined in accordance with the identification method of the present invention, whereby said group of patients is known or suspected to suffer from or being prone to suffer from gastric cancer, in particular invasive gastric cancer.

公开(公告)号：EP2412824A1

公开(公告)日：2012-02-01

申请号：EP10194720.8

申请日：2007-01-11

Applicant: Genomic Health, Inc. ,  NSABP Foundation, Inc.

Inventor： Cowens, Wayne ,  Baker, Joffre ,  Hackett, James ,  Watson, Drew ,  Paik, Soonmyung ,  Clark, Kim

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N33/57419 ,  G01N33/57446

Abstract: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of an RNA transcript of EREG or its expression product in a biological sample of cancer cells obtained from the subject.

Abstract translation: 预测诊断患有结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中EREG或其表达产物的RNA转录物的表达的证据。

公开(公告)号：EP2412822A1

公开(公告)日：2012-02-01

申请号：EP10194717.4

申请日：2007-01-11

Applicant: Genomic Health, Inc. ,  NSABP Foundation, Inc.

Inventor： Cowens, Wayne ,  Baker, Joffre ,  Hackett, James ,  Watson, Drew ,  Paik, Soonmyung ,  Clark, Kim

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N33/57419 ,  G01N33/57446

Abstract: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of an RNA transcript of GADD45B or an expression product thereof in a biological sample of cancer cells obtained from the subject.

Abstract translation: 预测诊断患有结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中GADD45B或其表达产物的RNA转录物的表达的证据。

公开(公告)号：EP2407553A1

公开(公告)日：2012-01-18

申请号：EP10194715.8

申请日：2007-01-11

Applicant: Genomic Health, Inc. ,  NSABP Foundation, Inc.

Inventor： Cowens, Wayne ,  Baker, Joffre ,  Hackett, James ,  Watson, Drew ,  Paik, Soonmyung ,  Clark, Kim

IPC: C12Q1/68 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N33/57419 ,  G01N33/57446

Abstract: A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of an RNA transcript of cMYC or an expression product thereof in a biological sample of cancer cells obtained from the subject.

Abstract translation: 一种预测诊断为结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中cMYC或其表达产物的RNA转录物的表达的证据。