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    Gene expression markers for colorectal cancer prognosis
    3.
    发明公开
    Gene expression markers for colorectal cancer prognosis 有权
    Genexpressionsmarker zur Kolorektalkrebsprognose

    公开(公告)号：EP2377950A1

    公开(公告)日：2011-10-19

    申请号：EP10177406.5

    申请日：2007-01-11

    申请人： Genomic Health, Inc. ,  NSABP Foundation, Inc.

    发明人： Cowens, Wayne ,  Baker, Joffre B. ,  Clark, Kim ,  Hackett, James ,  Watson, Drew ,  Paik, Soonmyung

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N33/57419 ,  G01N33/57446

    摘要： A method of predicting clinical outcome for a human subject diagnosed with colorectal cancer following surgical resection of said cancer is disclosed. A normalized expression level is determined of an RNA transcript of MYBL2, or an expression product thereof, in a biological sample comprising cancer cells obtained from said human subject. The likelihood of a positive clinical outcome for said human subject is then predicted based on said normalized expression level, wherein normalized expression of an RNA transcript of MYBL2, or an expression product thereof, is positively correlated with an increased likelihood of a positive clinical outcome.

    摘要翻译： 公开了一种用于预测所述癌症手术切除后诊断为结肠直肠癌的人类受试者的临床结果的方法。 在包含从所述人受试者获得的癌细胞的生物样品中确定MYBL2或其表达产物的RNA转录物的归一化表达水平。 然后基于所述归一化表达水平预测所述人受试者的阳性临床结果的可能性，其中MYBL2或其表达产物的RNA转录物的标准化表达与阳性临床结果的增加的可能性呈正相关。

    IDENTIFICATION AND USE OF PROGNOSTIC AND PREDICTIVE MARKERS IN CANCER TREATMENT
    4.
    发明公开
    IDENTIFICATION AND USE OF PROGNOSTIC AND PREDICTIVE MARKERS IN CANCER TREATMENT 审中-公开
    鉴定及预后标志物的使用和预测癌症治疗

    公开(公告)号：EP1825003A2

    公开(公告)日：2007-08-29

    申请号：EP05854106.1

    申请日：2005-12-15

    申请人： NSABP Foundation, Inc.

    发明人： PAIK, Soonmyung ,  KIM, Chungyeul

    IPC分类号： C12Q1/68 ,  A61K39/395 ,  A61K39/40

    CPC分类号： G01N33/5082 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57415 ,  G01N33/57492 ,  G01N33/6845 ,  G01N2500/00

    摘要： The present invention provides a method of screening for markers useful in predicting the efficacy of a specified cancer that includes: (a) constructing a tissue microarray from a tissue bank comprising multiple tissue samples that are annotated with clinical follow up data; (b) labeling polynucleic acid probes specific for oncogenes or cancer associated genes known to be potential amplicons; (c) performing fluorescent in situ hybridization analysis on the tissue microarray; and (d) correlating the result of the fluorescent in situ hybridization with the clinical follow up data. In addition, the present invention provides a method of treating breast cancer that includes measuring the expression levels or amplification of HTPAP in a patient having breast cancer and then providing a patient having increased levels of HTPAP expression or HTPAP amplification with therapeutic quantities of at least one compound that interferes with the phosphatidic acid phosphatase activity of HTPAP. The present invention also encompasses a method of treating breast cancer that includes screening a breast cancer patient for amplification of the cMYC gene and then treating a patient having amplification of the cMYC gene with therapeutic quantities of a compound that interferes with HER2 signaling.