公开(公告)号：EP3632899A1

公开(公告)日：2020-04-08

申请号：EP19210864.5

申请日：2010-05-31

申请人： RaQualia Pharma Inc.

发明人： INOUE, Tadashi ,  WATANABE, Shuzo ,  YAMAGISHI, Tatsuya ,  ARANO, Yoshimasa ,  MORITA, Mikio ,  SHIMADA, Kaoru

IPC分类号： C07D213/65 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/506 ,  A61P1/00 ,  A61P1/18 ,  A61P9/00 ,  A61P9/06 ,  A61P13/00 ,  A61P13/10 ,  A61P15/00 ,  A61P19/02 ,  A61P21/02

摘要： The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blockers such as Na V1.3 and Na V1.7 , and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.

公开(公告)号：EP2435407B1

公开(公告)日：2019-12-25

申请号：EP10780311.6

申请日：2010-05-31

申请人： RaQualia Pharma Inc.

发明人： INOUE, Tadashi ,  WATANABE, Shuzo ,  YAMAGISHI, Tatsuya ,  ARANO, Yoshimasa ,  MORITA, Mikio ,  SHIMADA, Kaoru

IPC分类号： C07D213/65 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/506 ,  A61P1/00 ,  A61P1/18 ,  A61P9/00 ,  A61P9/06 ,  A61P13/00 ,  A61P13/10 ,  A61P15/00 ,  A61P19/02 ,  A61P21/02

公开(公告)号：EP2968992B1

公开(公告)日：2019-12-11

申请号：EP14762323.5

申请日：2014-03-14

申请人： Tonix Pharma Holdings Limited

发明人： NEBULONI, Marino ,  COLOMBO, Patrizia

IPC分类号： A61P21/02 ,  A61K9/14 ,  A61K9/16 ,  A61K31/135 ,  A61P43/00

摘要： The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol or Amitriptyline HCl and mannitol.

公开(公告)号：EP3501530A1

公开(公告)日：2019-06-26

申请号：EP18185393.8

申请日：2018-07-25

申请人： Iyer, Ravi Ramamoorthy

发明人： Iyer, Ravi Ramamoorthy

IPC分类号： A61K36/9066 ,  A61K36/324 ,  A61K36/534 ,  A61K36/54 ,  A61K36/61 ,  A61K36/67 ,  A61P21/02 ,  A61P21/00 ,  A61P19/02

摘要： A topical liniment composition that boost muscle relaxation, increase blood flow, and increase cutaneous delivery of herbal extract that contains polyphenols derived from red chili, black pepper, cinnamon, and turmeric includes a quantity of castor-mineral oil-camphor solution, a quantity of eucalyptus oil, a quantity of clove oil, a quantity of peppermint oil, a quantity of frankincense oil, a quantity of herbal extract concentrate solution, and a quantity of castor oil. Aforementioned ingredients are heterogeneously mixed with each other to formulate the topical liniment composition at standard temperature and pressure (STP). Additionally, a quantity of petroleum jelly and a quantity of beeswax can be heterogeneously mixed with the topical liniment composition to formulate the topical balm composition.

公开(公告)号：EP3257511B1

公开(公告)日：2018-10-24

申请号：EP15882014.2

申请日：2015-09-10

申请人： FUJIFILM Corporation

发明人： OKADA, Kotaro ,  MORI, Hisahiro ,  TSUJIHATA, Shigetomo ,  SAKATA, Yoshinori

IPC分类号： A61K31/46 ,  A61K9/20 ,  A61K47/04 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/32 ,  A61P1/06 ,  A61P13/06 ,  A61P21/02 ,  A61P25/08

CPC分类号： A61K9/0056 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2081 ,  A61K9/2086 ,  A61K9/2095 ,  A61K31/46 ,  A61K31/5383

摘要： An orally disintegrating tablet including: fine granules, each fine granule having, at its center, an active pharmaceutical ingredient-containing core that includes butylscopolamine bromide and water-insoluble particles, and having an intermediate layer that includes water-insoluble particles and coats the active pharmaceutical ingredient-containing core, and a bitterness-masking layer that includes talc and at least one water-insoluble polymer, in sequence from the active pharmaceutical ingredient-containing core side; and an excipient component positioned on the outside of the fine granules, and a method for producing the same.

公开(公告)号：EP3194026A4

公开(公告)日：2018-05-16

申请号：EP15842827

申请日：2015-09-17

申请人： DART NEUROSCIENCE CAYMAN LTD

发明人： TULLY TIMOTHY ,  PERERA PHILIP

IPC分类号： A61P21/02 ,  A61K45/06 ,  A63B21/00 ,  A63B21/002

CPC分类号： A61K31/47 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/435 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4725 ,  A61K45/06

摘要： Methods of rehabilitation of neurological disorders, including neurological deficits associated with neurotraumas, such as stroke and traumatic brain injury, and with muscle disorders, that includes administering to a subject a MAO-B inhibitor.

公开(公告)号：EP3204097A1

公开(公告)日：2017-08-16

申请号：EP15848881.7

申请日：2015-10-08

申请人： Solaeromed Inc.

发明人： DENNIS, John H. ,  MCAFFER, Ian G. C. ,  DALBERG, Stefan ,  GREEN, Francis ,  CLARK, Andy

IPC分类号： A61M11/02 ,  A61K31/02 ,  A61K31/025 ,  A61K31/131 ,  A61K31/341 ,  A61K9/72 ,  A61M15/00 ,  A61P11/00 ,  A61P21/02

CPC分类号： A61M11/02 ,  A61K31/02 ,  A61M11/003 ,  A61M11/04 ,  A61M15/0025 ,  A61M15/009 ,  A61M2202/0476 ,  A61M2205/7536 ,  A61M2205/8225 ,  A61M2210/1035

摘要： Disclosed are apparatus and methods for producing and delivering vapour medicament. An exemplary apparatus disclosed comprises: a gas inlet for receiving a gas from a source of pressurized gas; a chamber for receiving a liquid medicament therein, the chamber being in communication with the gas inlet for permitting entrance and expansion of the gas in the chamber in the presence of the liquid medicament to produce the vapour medicament; and a vapour outlet in communication with the chamber for delivering the vapour medicament.

摘要翻译： 公开了用于生产和输送蒸汽药剂的设备和方法。 所公开的示例性设备包括：用于接收来自加压气体源的气体的气体入口; 用于在其中接收液体药剂的腔室，腔室与气体入口连通以允许在存在液体药剂的情况下腔室中的气体进入和扩展以产生蒸气药剂; 以及与腔室连通以输送蒸气药剂的蒸气出口。

公开(公告)号：EP1824488B1

公开(公告)日：2017-08-09

申请号：EP05747904.0

申请日：2005-05-06

申请人： Algenis SpA

发明人： WILSON, Nestor Antonio Lagos

IPC分类号： A61K31/519 ,  A61P23/00 ,  A61P21/02 ,  A61K31/505

CPC分类号： A61K31/505 ,  Y02A50/469

摘要： Pharmaceutical compositions comprising tricyclic 3,4-propinoperhydropurines and uses thereof for blocking neuronal transmission which are useful in treating anal fissure and other wounds and muscle disorders are provided. Also provided are methods of treating wounds and muscle disorders by administering the composition of the invention to a muscle or in the vicinity of a muscle either topically or by injection.

摘要翻译： 提供了包含三环3,4-丙酮全氢嘌呤的药物组合物及其用于阻断神经元传递的用途，其可用于治疗肛裂和其他伤口以及肌肉病症。 还提供了通过局部或通过注射将本发明的组合物施用于肌肉或肌肉附近来治疗伤口和肌肉病症的方法。

公开(公告)号：EP3193854A1

公开(公告)日：2017-07-26

申请号：EP15841528.1

申请日：2015-09-18

申请人： Tonix Pharma Holdings Limited

发明人： LEDERMAN, Seth ,  NEBULONI, Marino

IPC分类号： A61K31/135 ,  A61K31/047 ,  A61P21/02

CPC分类号： A61K31/135 ,  A61K9/1623 ,  A61K9/2018 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12

摘要： The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol.

摘要翻译： 本发明涉及药物组合物及其制造方法，包括环苯扎林HCl和甘露醇的共晶。

公开(公告)号：EP2809320B1

公开(公告)日：2017-03-22

申请号：EP13701807.3

申请日：2013-02-01

申请人： Grünenthal GmbH

发明人： FROSCH, Stefanie ,  LINZ, Klaus ,  BLOMS-FUNKE, Petra

IPC分类号： A61K31/407 ,  A61P21/02

CPC分类号： A61K31/407