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公开(公告)号：EP3607943A1
公开(公告)日：2020-02-12
申请号：EP19194585.6
申请日：2012-04-03
申请人： Grünenthal GmbH
发明人： CHRISTOPH, Thomas , DE VRY, Jean , TZSCHENTKE, Thomas , BLOMS-FUNKE, Petra , SCHIENE, Klaus , HAMON, Michel
IPC分类号： A61K31/137 , A61K9/00 , A61K9/20 , A61P25/00 , A61P25/04
摘要： The invention relates to tapentadol for use in the treatment of pain associated with disorders of the trigeminal nerve, in particular for use in the treatment of pain associated with trigeminal neuralgia.
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2.发明授权GESÄTTIGTE UND UNGESÄTTIGTE HETEROARYLCYCLOALKYMETHYL-AMINE ALS ANTIDEPRESSIVA 有权饱和和非饱和HETEROARYLCYCLOALKYMETHYL胺抗抑郁药
公开(公告)号：EP1572653B1
公开(公告)日：2007-11-21
申请号：EP03815065.2
申请日：2003-12-19
申请人： Grünenthal GmbH
发明人： BLOMS-FUNKE, Petra , PÜTZ, Claudia , GRAUDUMS, Ivars , KLESS, Achim , GRIEBEL, Carsten , HENNIES, Hagen-Heinrich , KAULARTZ, Dagmar , REINARDY, Sabine , SAUNDERS, Derek , SCHIENE, Klaus , ENGLBERGER, Werner , ZIMMER, Oswald ,
IPC分类号： C07D213/38 , C07D213/61 , C07D213/65 , C07D405/04 , A61K31/4433 , A61K31/44 , A61P25/24 , A61P29/00
CPC分类号： C07D405/04 , C07D213/38 , C07D213/61 , C07D213/65
摘要： The invention relates to saturated and unsaturated heteroarylcycloalkylmethyl amines of general formula (I) wherein W is equal to CH2, O, S, SO or SO2, and n is equal to a number between 0 and 3. The invention also relates to a method for the production of said compounds, to medicaments containing the same, to the use of said compounds for producing medicaments, and to methods for treating depression, anxiety disorders and/or pain.
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3.发明公开GESÄTTIGTE UND UNGESÄTTIGTE 3-PYRIDYL-BENZOCYCLOALKYLMETHYL-AMINE ZUR BEHANDLUNG VON SCHMERZEN, DEPRESSIONEN UND ANGSTZUSTÄNDEN 有权饱和，非饱和3吡啶benzocycloalkylmethyl胺为疼痛，抑郁和焦虑的治疗
公开(公告)号：EP1758860A1
公开(公告)日：2007-03-07
申请号：EP05766092.0
申请日：2005-06-20
申请人： Grünenthal GmbH
发明人： SUNDERMANN, Bernd , HENNIES, Hagen-Heinrich , SCHIENE, Klaus , BLOMS-FUNKE, Petra , ENGLBERGER, Werner , FRORMANN, Sven , SAUNDERS, Derek
IPC分类号： C07D213/38 , C07D417/06 , C07D413/06 , A61K31/435 , A61P25/00
CPC分类号： C07D417/06 , C07D213/38 , C07D413/06
摘要： The invention relates to the saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines of general formula (I), to methods for producing drugs containing said compounds, to the use of saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines in the production of drugs and to methods for treating pains, depressions and/or anxiety states.
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4.发明公开SUBSTITUIERTE 5,6,6A,11B-TETRAHYDRO-7-OXA-5-AZA-BENZO[C]FLUOREN-6-CARBONSÄUREDERIVATE ALS NMDA-ANTAGONISTEN 有权取代的5,6,6a，11B四氢-7-氧杂-5-氮杂 - 苯并[c]芴-6-羧酸衍生物作为NMDA拮抗剂
公开(公告)号：EP1412361A1
公开(公告)日：2004-04-28
申请号：EP02764838.5
申请日：2002-08-05
申请人： Grünenthal GmbH
发明人： GERLACH, Matthias , PRZEWOSNY, Michael , ENGLBERGER, Werner, Günter , REISSMÜLLER, Elke , BLOMS-FUNKE, Petra , MAUL, Corinna , JAGUSCH, Utz-Peter
IPC分类号： C07D491/04 , A61K31/445 , A61K31/34 , A61P25/04 , A61P25/06 , A61P25/00
CPC分类号： C07D491/04
摘要： The invention relates to substituted 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid derivatives, to methods for the production thereof, medicaments containing these compounds, and to their use for producing medicaments for certain indications, particularly for treating pain.
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5.发明授权INTRATHECAL OR EPIDURAL ADMINISTRATION OF 3-[(1S,2S)-3-(DIMETHYLAMINO)-1-ETHYL-2-METHYLPROPYL]PHENOL 有权3 - [（1S，2S）-3-（二甲基氨基）-1-乙基-2-甲基丙基]苯酚鞘内或硬膜外给药
公开(公告)号：EP2736501B1
公开(公告)日：2017-12-20
申请号：EP12747973.1
申请日：2012-07-27
申请人： Grünenthal GmbH
IPC分类号： A61K31/137 , A61K45/06 , A61P25/04 , A61K9/00
CPC分类号： A61K9/0085 , A61K31/135 , A61K31/137 , A61K45/06
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6.发明公开PHARMACEUTICAL COMBINATION OF 3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL AND AN ANTIEPILEPTIC 有权从3-（3-二甲基氨基-1-乙基-2-甲基 - 丙基） - 苯酚和甲抗癫痫药物化合物
公开(公告)号：EP2331210A2
公开(公告)日：2011-06-15
申请号：EP09778335.1
申请日：2009-09-04
申请人： Grünenthal GmbH
IPC分类号： A61P25/04 , A61K31/137
CPC分类号： A61K45/06 , A61K31/137 , A61K2300/00
摘要： A composition of matter comprising in combination as component (a) at least one 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol compound, and as component (b) at least one antiepileptic, a pharmaceutical formulation and a dosage form comprising said composition of matter, and a method of treating pain, e.g. neuropathic pain, in which components (a) and (b) are administered simultaneously or sequentially to a mammal, whereby component (a) may be administered before or after component (b) and whereby components (a) or (b) are administered to the mammal either via the same or a different pathway of administration.
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7.发明授权VERWENDUNG VON C-(2-PHENYL-CYCLOHEXYL)-METHYLAMINVERBINDUNGEN ZUR THERAPIE VON ANGSTSTÖRUNGEN 有权C-（2-苯基环己基）-METHYLAMINVERBINDUNGEN用于治疗焦虑症USE
公开(公告)号：EP1686984B1
公开(公告)日：2011-05-18
申请号：EP04819227.2
申请日：2004-11-26
申请人： Grünenthal GmbH
IPC分类号： A61K31/35 , A61K31/137 , A61K31/145 , A61P25/22 , A61P25/24
CPC分类号： A61K31/137 , A61K31/145 , A61K31/35
摘要： The invention relates to the use of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for producing a medicament that is used for treating anxiety attacks or for producing an adjuvant to standard antidepressants. Also disclosed are methods for the treatment of anxiety attacks or depressions.
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公开(公告)号：EP2155179B1
公开(公告)日：2010-12-01
申请号：EP08758440.5
申请日：2008-05-09
申请人： Grünenthal GmbH
IPC分类号： A61K31/135 , A61P19/02 , A61P25/04
CPC分类号： A61K31/135
摘要： The invention relates to the use of axomadol for producing a medication for treating pain from arthritis.
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9.发明公开SUBSTITUIERTE AMINOVERBINDUNGEN ALS 5-HT/NA UPTAKEHEMMER 有权SUBSTITUIERTE AMINOVERBINDUNGEN ALS 5-HT / NA越来越多
公开(公告)号：EP1768948A1
公开(公告)日：2007-04-04
申请号：EP05758901.2
申请日：2005-07-12
申请人： Grünenthal GmbH
发明人： BLOMS-FUNKE, Petra , FRIDERICHS, Elmar , GRAUDUMS, Ivars , HENNIES, Hagen-Heinrich , KLESS, Achim , SCHIENE, Klaus , ZIMMER, Oswald
IPC分类号： C07C211/28 , C07C211/29 , A61K31/135 , A61P13/06 , A61P25/22 , A61P25/24 , A61P29/02
CPC分类号： C07C211/29 , C07C2601/18
摘要： The invention relates to substituted amino compounds, methods for the production thereof, medicaments containing said compounds, the use of said substances for producing medicaments, preferably for the treatment of depressions, anxiety attacks, pain, and renal incontinence, and methods for treating said diseases.
摘要翻译： 本发明涉及取代的氨基化合物，其制备方法，含有这些化合物的药物制剂以及这些物质在制备药物制剂中的用途，特别是用于治疗或抑制抑郁症，焦虑症，疼痛和尿失禁， 以及治疗或抑制这些疾病的相关方法。
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公开(公告)号：EP1254118B1
公开(公告)日：2005-11-09
申请号：EP01901176.6
申请日：2001-01-19
申请人： Grünenthal GmbH
发明人： GERLACH, Matthias , PRZEWOSNY, Michael , ENGLBERGER, Werner , REISSMÜLLER, Elke , BLOMS-FUNKE, Petra , MAUL, Corinna , JAGUSCH, Utz-Peter
IPC分类号： C07D215/48 , A61K31/47 , A61P25/32 , C07D221/16 , C07D221/22 , C07D491/04 , C07D495/04
CPC分类号： C07D221/22 , C07D215/48 , C07D221/16 , C07D221/18 , C07D405/04 , C07D491/04 , C07D495/04
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