公开(公告)号：EP2432799A1

公开(公告)日：2012-03-28

申请号：EP10723079.9

申请日：2010-05-20

Applicant: Pierre Fabre Medicament ,  Centre National de la Recherche Scientifique (C.N.R.S.)

Inventor： LONG, Christophe ,  GUMINSKI, Yves ,  DERGUINI, Fadila ,  BECK, Joséphine ,  CANTAGREL, Frédéric

IPC: C07J53/00 ,  C07J71/00 ,  A61K31/58 ,  A61K31/575 ,  A61P35/00

CPC classification number: C07J53/004 ,  C07J71/0005

Abstract: The present invention relates to a compound with the following formula (I), or to a pharmaceutically acceptable salt thereof, as well as to pharmaceutical compositions including same and to the use thereof as a drug, in particular for treating a proliferative disease such as cancer.

公开(公告)号：EP2417149A1

公开(公告)日：2012-02-15

申请号：EP10714129.3

申请日：2010-04-06

Applicant: Evestra, Inc.

Inventor： NICKISCH, Klaus ,  ACOSTA, Kirk ,  SANTHAMMA, Bindu

IPC: C07J21/00 ,  C07J41/00 ,  C07J53/00

CPC classification number: C07J21/003 ,  C07J41/0094 ,  C07J53/008

Abstract: Described herein are methods of making drospirenone. Also described are intermediate compounds that may be used to synthesis drospirenone.

公开(公告)号：EP0918791B3

公开(公告)日：2012-01-18

申请号：EP97937562.3

申请日：1997-08-11

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： MOHR, Jörg-Thorsten ,  NICKISCH, Klaus

IPC: C07J53/00

CPC classification number: C07J53/007 ,  C07J53/008

公开(公告)号：EP2250185A4

公开(公告)日：2011-11-16

申请号：EP08869088

申请日：2008-12-23

Applicant: VIROCHEM PHARMA INC

Inventor： MOINET CHRISTOPHE ,  HALAB LILIANE ,  TURCOTTE NATHALIE ,  BUBENIK MONICA ,  COURCHESNE MARC ,  POISSON CARL ,  PEREIRA OSWY Z ,  NGUYEN-BA PAUL ,  LIU BINGCAN ,  CHAURET NATHALIE ,  CADILHAC CAROLINE ,  CHAN CHUN KONG LAVAL

IPC: C07J63/00 ,  A61K31/575 ,  A61K31/58 ,  A61K38/55 ,  A61K45/00 ,  A61K45/06 ,  A61P31/12 ,  A61P31/18 ,  C07J41/00 ,  C07J43/00 ,  C07J53/00

CPC classification number: A61K45/06 ,  A61K31/575 ,  A61K31/58 ,  A61K38/05 ,  A61K38/55 ,  A61K2300/00

公开(公告)号：EP2265629A2

公开(公告)日：2010-12-29

申请号：EP09718334.7

申请日：2009-03-04

Applicant: Evestra, Inc.

Inventor： NICKISCH, Klaus ,  RAO, Pemmaranu N. ,  CESSAC, James W. ,  SIMMONS, Anne Marie

IPC: C07J53/00 ,  A61K31/58 ,  A61P5/34 ,  A61P5/42

CPC classification number: C07J53/007 ,  C07J53/008

Abstract: Described herein are bismethylene-17α carbolactone derivatives having progestational and/or antimineralocorticoid and/or aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.

公开(公告)号：EP2240504A1

公开(公告)日：2010-10-20

申请号：EP08867782.8

申请日：2008-12-23

Applicant: Virochem Pharma Inc.

Inventor： MOINET, Christophe ,  CHAN CHUN KONG, LAVAL ,  COURCHESNE, Marc ,  HALAB, LILIANE ,  CHAURET, Nathalie

IPC: C07J63/00 ,  A61K31/575 ,  A61K31/58 ,  A61K45/00 ,  A61P31/12 ,  A61P31/18 ,  C07J41/00 ,  C07J43/00 ,  C07J53/00

CPC classification number: A61K31/575 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention relates to 21 -keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.

公开(公告)号：EP2238151A1

公开(公告)日：2010-10-13

申请号：EP08868806.4

申请日：2008-12-23

Applicant: Bayer Schering Pharma Aktiengesellschaft

Inventor： KLAR, Ulrich ,  KUHNKE, Joachim ,  BOHLMANN, Rolf ,  HÜBNER, Jan ,  RING, Sven ,  FRENZEL, Thomas ,  MENGES, Frederik ,  BORDEN, Steffen ,  MUHN, Hans, Peter ,  PRELLE, Katja

IPC: C07J53/00 ,  A61P5/34 ,  A61K31/585

CPC classification number: C07J53/00 ,  C07J19/00

Abstract: The invention relates to 17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivatives with the chemical formula (I) wherein R4, R6a, R6b, R7, R15, R16a, R16b, R18 and Z have the designations given in claim 1, and to the solvates, hydrates, stereoisomers and salts thereof. The invention also relates to the use of said derivatives for producing a medicament for oral contraception and for the treatment of premenopausal, perimenopausal and postmenopausal troubles, and medicaments containing said derivatives. The derivatives according to the invention have a gestagen effect, and in preferred cases, also an anti-mineral corticoid and neutral to lightly androgenous effect.

公开(公告)号：EP2238150A1

公开(公告)日：2010-10-13

申请号：EP08868567.2

申请日：2008-12-23

Applicant: Bayer Schering Pharma Aktiengesellschaft

Inventor： KLAR, Ulrich ,  KUHNKE, Joachim ,  BOHLMANN, Rolf ,  HÜBNER, Jan ,  RING, Sven ,  FRENZEL, Thomas ,  MENGES, Frederik ,  BORDEN, Steffen ,  MUHN, Hans, Peter ,  PRELLE, Katja

IPC: C07J53/00 ,  A61K31/58 ,  A61P5/34 ,  A61P5/42 ,  A61P5/28

CPC classification number: C07J53/008

Abstract: The invention relates to a 15, 16-methylene-17-hydroxy-19-nor-21 -carboxylic acid-steroid γ-lactone derivative with general chemical formula (I) wherein R4, R6a, R6b, R7 and Z have the designations given in claim 1, and to the solvates, hydrates, stereoisomers and salts thereof. The invention also relates to the use of said derivatives for producing a medicament for oral contraception and for the treatment of premenopausal, perimenopausal and postmenopausal complaints, and medicaments containing said derivatives. The derivatives according to the invention have a gestagenic effect, and in preferred cases, also an anti-mineral corticoidal and neutral to lightly androgenous effect.

公开(公告)号：EP2088152A4

公开(公告)日：2010-03-10

申请号：EP07852031

申请日：2007-10-24

Applicant: INST NEFTEKHIMII I KATALIZA RO

Inventor： DZHEMILEV USEIN MEMETOVICH ,  TOLSTIKOV GENRIKH ALEXANDROVICH ,  POKROVSKY ANDREI GEORGIEVICH ,  SALAKHUTDINOV NARIMAN FARIDOVICH ,  TOLSTIKOVA TATYANA GENRIKHOVNA ,  SHULTS ELVIRA EDUARDOVNA

IPC: C07K5/062 ,  A61K38/05 ,  A61P31/18 ,  C07J53/00 ,  C07J63/00

CPC classification number: C07J53/00 ,  C07J63/00

公开(公告)号：EP2037872A2

公开(公告)日：2009-03-25

申请号：EP07730819.5

申请日：2007-06-06

Applicant: Valtion Teknillinen Tutkimuskeskus

Inventor： YLI-KAUHALUOMA, Jari ,  KOSKIMIES, Salme ,  ALAKURTTI, Sami ,  BERGSTRÖM, Pia ,  AHLNÄS, Thomas ,  MEINANDER, Kristian ,  TAMMELA, Päivi

IPC: A61K8/63 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q99/00 ,  C07J63/00 ,  C07J71/00 ,  A61K31/56 ,  A61P31/04 ,  C07J53/00

CPC classification number: A61K31/56 ,  C07J53/00 ,  C07J63/00 ,  C07J71/00 ,  Y02A50/409

Abstract: The invention relates to compouns derived from betulin, and to the use thereof as antibacterial agents in pharmaceutical and cosmetic applications.