公开(公告)号：EP0935654A1

公开(公告)日：1999-08-18

申请号：EP97916166.0

申请日：1997-03-21

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： NATHANS, Jeremy ,  SMALLWOOD, Philip, M. ,  TONG, Patrick

IPC分类号： C12N15 ,  A61K31 ,  A61K35 ,  A61K48 ,  A61K49 ,  A61K51 ,  A61P25 ,  A61P35 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12P21 ,  A61K38

CPC分类号： C07K14/50 ,  A61K38/00 ,  C12N2799/027

摘要： A novel protein, fibroblast growth factor homologous factor-3 (FHF-3), the polynucleotide sequence encoding FHF-3, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-3 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-3.

公开(公告)号：EP0929318A2

公开(公告)日：1999-07-21

申请号：EP97936164.0

申请日：1997-08-04

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE ,  THE UNITED STATES OF AMERICA

发明人： PARDOLL, Drew, M. ,  JAFFEE, Elizabeth, M. ,  ADLER, Adam ,  TOPALIAN, Suzanne, L. ,  ROSENBERG, Steven, A.

IPC分类号： A61K48 ,  A61K35 ,  A61K39 ,  A61P35

CPC分类号： A61K39/0011 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/5152 ,  A61K2039/5156 ,  A61K2039/55522

摘要： The invention pertains to a method of treating or protecting against melanoma that comprises (a) obtaining a melanoma cell line that expresses one or more shared immunodominant melanoma antigens, (b) modifying the melanoma cell line to render it capable of producing an increased level of a citokyne relative to the unmodified cell line, and (c) administering the melanoma cell line to a mammalian host that has melanoma or is at risk for developing melanoma. Preferably the melanoma cell line is allogenic and is not MHC-matched to the host.

公开(公告)号：EP0852467A1

公开(公告)日：1998-07-15

申请号：EP96933034.0

申请日：1996-09-13

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： FAHEY, Jed, W., J.Hopkins Univ. School of Medicine ,  TALALAY, Paul, J. Hopkins Univ. School of Medicine

IPC分类号： A01H5 ,  A21D2 ,  A21D13 ,  A23L1 ,  A23L2 ,  A61K31 ,  A61K36 ,  A61P35

CPC分类号： A21D2/36 ,  A23L11/20 ,  A23L19/03 ,  A23L19/09 ,  A23L25/30 ,  A23L33/105 ,  A61K36/31 ,  A61K2300/00

摘要： Vegetable sources of cancer chemoprotective agents have been identified which are extraordinarily rich in glucosinolates, metabolic precursors of isothiocyanates. The vegetable sources are used to provide a dietary means of reducing the level of carcinogens in mammals.

公开(公告)号：EP0832109A1

公开(公告)日：1998-04-01

申请号：EP96915686.0

申请日：1996-05-10

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： NATHANS, Jeremy ,  SMALLWOOD, Philip, M. ,  MACKE, Jennifer, P.

IPC分类号： G01N33 ,  A61K9 ,  A61K35 ,  A61K39 ,  A61K48 ,  A61P35 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21 ,  A61K38

CPC分类号： C07K16/22 ,  A61K38/00 ,  C07K14/50

摘要： A novel growth factor, fibroblast growth factor homologous factor-2 (FHF-2) polypeptide, the polynucleotide sequence encoding FHF-2 and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-2 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-2.

公开(公告)号：EP0825996A1

公开(公告)日：1998-03-04

申请号：EP96915685.0

申请日：1996-05-10

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： NATHANS, Jeremy ,  SMALLWOOD, Philip, M. ,  MACKE, Jennifer, P.

IPC分类号： G01N33 ,  A61K9 ,  A61K31 ,  A61K35 ,  A61K39 ,  A61K45 ,  A61K48 ,  A61K49 ,  A61P25 ,  A61P27 ,  A61P35 ,  C07K14 ,  C07K16 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  A61K38 ,  C12R1

CPC分类号： C07K16/22 ,  A61K38/00 ,  C07K14/50 ,  C12Q1/6886 ,  C12Q2600/158

摘要： A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-1 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-1.

公开(公告)号：EP0804214A1

公开(公告)日：1997-11-05

申请号：EP94922520.0

申请日：1994-07-08

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： LEE, Se-Jin ,  HUYNH, Thanh

IPC分类号： G01N33 ,  A61K9 ,  A61K31 ,  A61K39 ,  A61K48 ,  A61K49 ,  C07H21 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21 ,  A61K38

CPC分类号： C07K14/495 ,  A61K38/00 ,  C07K16/22

摘要： Growth differentiation factor-6 (GDF-6) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-6 polypeptide and polynucleotide sequences.

公开(公告)号：EP0799055A1

公开(公告)日：1997-10-08

申请号：EP95939164.0

申请日：1995-11-16

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： ZEIMER, Ran

IPC分类号： A61K9 ,  A61K41 ,  A61K45 ,  A61K49 ,  A61P41

CPC分类号： A61K49/0043 ,  A61K41/0042 ,  A61K49/0034 ,  A61K49/0084 ,  Y10S514/912

摘要： Disclosed are methods and materials for visualizing or treating vasculature. The methods and materials in this invention relate to selective and non-invasive visualization, or treatment such as chemical occlusion, of vasculature in the mammalian eye. The methods utilize fluorescent dyes and tissue-reactive substances encapsulated within heat-sensitive liposomes which are subsequently heated to release the contents thereof at a predetermined anatomical locus. The methods of this invention further utilize tissue-reactive agents which, when activated, are effective to cause localized tissue damage and occlusion of blood vessels and/or blood sinuses. The materials of this invention relate to diagnostic reagents and kits for visualizing or treating a mammalian blood vessel or sinus.

公开(公告)号：EP0792168A1

公开(公告)日：1997-09-03

申请号：EP95942863.0

申请日：1995-11-15

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： BAYLIN, Stephen B. ,  WALES, Michele Makos, Unit 1

IPC分类号： G01N33 ,  A61K35 ,  A61K48 ,  A61P1 ,  A61P7 ,  A61P13 ,  A61P15 ,  A61P25 ,  A61P31 ,  A61P35 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  A61K38

CPC分类号： C07K14/4703 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/027

摘要： Polynucleotide and polypeptide sequences encoding a novel tumor suppressor, HIC-1, are provided. Also included is a method for detecting a cell proliferative disorder associated with HIC-1. HIC-1 is a marker which can be used diagnostically, prognostically and therapeutically over the course of such disorders.

公开(公告)号：EP0784484A2

公开(公告)日：1997-07-23

申请号：EP95933167.0

申请日：1995-09-19

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE ,  THE ADMINISTRATORS OF THE TULANE UNIVERSITY EDUCATIONAL FUND

发明人： CLEMENTS, Janice E. ,  MURPHEY-CORB, Michael ,  ZINK, M.Christine

IPC分类号： C07K14 ,  C07K16 ,  C12N15 ,  A61K38

CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K16/1063 ,  C12N2740/15022

摘要： A method of treating a host prophylactically or therapeutically for infection with human immunodeficiency virus (HIV) is described. A simian immunodeficiency virus (SIV)-macaque monkey model shows that infection with a non-pathogenic, macrophage-tropic, recombinant SIV provides systemic immunity to the host by stimulation of production of neutralizing antibodies. Tests provided show that the neutralizing antibodies produced are broadly reactive with several heterologous strains of SIV. Also provided are pharmaceutical compositions useful for treatment of a subject prior to or following infection with HIV.

公开(公告)号：EP0770089A1

公开(公告)日：1997-05-02

申请号：EP95928062.0

申请日：1995-07-12

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： LEE, Se-Jin ,  ESQUELA, Aurora, F.

IPC分类号： G01N33 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61P1 ,  A61P35 ,  A61P43 ,  C07H21 ,  C07K14 ,  C07K16 ,  C12N15 ,  C12P21

CPC分类号： C07K14/475 ,  A61K38/00

摘要： Growth differentiation factor-12 (GDF-12) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-12 polypeptide and polynucleotide sequences.