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58 条记录 (耗时 0.035 秒)

    POLYCYCLO DYES AND USE THEREOF
    31.
    发明授权
    POLYCYCLO DYES AND USE THEREOF 有权

    公开(公告)号：EP2118206B9

    公开(公告)日：2018-08-29

    申请号：EP08729371.8

    申请日：2008-02-08

    申请人： VisEn Medical, Inc.

    发明人： NARAYANAN, Nara

    IPC分类号： C09B23/08 ,  C09B23/00

    CPC分类号： C09B23/0075 ,  C09B23/0033 ,  C09B23/005 ,  C09B23/0066

    摘要： The invention relates to a family of fluorescent compounds of Formula (I). The compounds can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications, and are particularly useful for the in vivo imaging of regions of interest within a mammal.

    FLUORESCENT IMAGING AGENTS
    32.
    发明公开
    FLUORESCENT IMAGING AGENTS 审中-公开
    荧光成像剂

    公开(公告)号：EP3320923A1

    公开(公告)日：2018-05-16

    申请号：EP17188506.4

    申请日：2009-01-17

    申请人： VisEn Medical, Inc.

    发明人： RAJOPADHYE, Milind ,  GROVES, Kevin ,  PREDA, Dorin V

    IPC分类号： A61K49/00 ,  A61K49/04

    CPC分类号： A61K49/0032 ,  A61K47/65 ,  A61K49/0056 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/64 ,  C09B23/0008 ,  C09B23/083 ,  C09B23/086

    摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

    摘要翻译： 提供了用于体内和体外成像的分子内猝灭成像剂家族，其包含至少一种酶促可裂解的寡肽和两种荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团不被猝灭，并且在用适当波长的光激发时能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。

    POLYCYCLO DYES AND USE THEREOF
    33.
    发明授权
    POLYCYCLO DYES AND USE THEREOF 有权
    POLYCYCLO染料及其用途

    公开(公告)号：EP2118206B1

    公开(公告)日：2018-04-11

    申请号：EP08729371.8

    申请日：2008-02-08

    申请人： VisEn Medical, Inc.

    发明人： NARAYANAN, Nara

    IPC分类号： C09B23/08 ,  C09B23/00

    CPC分类号： C09B23/0075 ,  C09B23/0033 ,  C09B23/005 ,  C09B23/0066

    摘要： The invention relates to a family of fluorescent compounds of Formula (I). The compounds can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications, and are particularly useful for the in vivo imaging of regions of interest within a mammal.

    Imaging Volumes with Arbitrary Geometries in Contact and Non-Contact Tomography
    37.
    发明公开
    Imaging Volumes with Arbitrary Geometries in Contact and Non-Contact Tomography 审中-公开
    BildgebungsdatenträgermitwillkürlichenGeometrien bei Kontakt- und kontaktloser Tomographie

    公开(公告)号：EP2410315A2

    公开(公告)日：2012-01-25

    申请号：EP11182730.9

    申请日：2003-06-04

    申请人： Visen Medical, Inc.

    发明人： Ripoll, Jorge ,  Ntziachristos, Vasilis ,  Madden, Karen N

    IPC分类号： G01N21/47 ,  A61B5/00

    摘要： A method for tomographic imaging of diffuse medium includes directing waves into a diffusive medium, solving a surface-bounded inversion problem by forward field calculations calculations through decomposition of contributions from the multiple reflections from an arbitrary surface within the diffusive medium or outside the diffusive medium into a sum of different orders of reflection up to an arbitrary order, and using contact or non-contact measurements of waves outside said diffusive medium to generate a tomographic image.

    摘要翻译： 扩散介质的层析成像方法包括将波浪引导到漫射介质中，通过前向场计算计算来解析表面有界的反转问题，通过分解来自扩散介质内或漫射介质外的任意表面的多次反射的贡献，分解成 不同顺序的反射到达任意顺序的总和，以及使用在所述漫射介质之外的波的接触或非接触测量来产生断层图像。

    BIOCOMPATIBLE FLUORESCENT METAL OXIDE NANOPARTICLES
    40.
    发明公开
    BIOCOMPATIBLE FLUORESCENT METAL OXIDE NANOPARTICLES 有权
    生物活性荧光素金属氧化物-NANOTEILCHEN

    公开(公告)号：EP1973575A2

    公开(公告)日：2008-10-01

    申请号：EP06851312.6

    申请日：2006-12-22

    申请人： Visen Medical, Inc.

    发明人： GROVES, Kevin ,  RAJOPADHYE, Milind

    IPC分类号： A61K49/00 ,  A61K49/18

    CPC分类号： A61K49/1866 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0056 ,  A61K49/0093 ,  A61K49/1833 ,  A61K49/186 ,  B82Y5/00

    摘要： The invention relates to highly fluorescent metal oxide nanoparticles to which biomolecules and other compounds can be chemically linked to form biocompatible, stable optical imaging agents for in vitro and in vivo applications. The fluorescent metal oxide nanoparticles may also be used for magnetic resonance imaging (MRI), thus providing a multi modality imaging agent.

    摘要翻译： 本发明涉及高度荧光的金属氧化物纳米颗粒，生物分子和其它化合物可以化学连接，以形成用于体外和体内应用的生物相容性，稳定的光学成像剂。 荧光金属氧化物纳米颗粒也可用于磁共振成像（MRI），从而提供多模式成像剂。