公开(公告)号：EP3383436A1

公开(公告)日：2018-10-10

申请号：EP16870081.3

申请日：2016-11-29

Applicant: Dishman Pharmaceuticals And Chemicals Limited

Inventor： VYAS, Janmejay, Rajnikant ,  DHOTRE, Himani ,  SARMA, Narasimha ,  PATEL, Babulal, R. ,  SHARMA, Dinesh, Kumar ,  PATEL, Dilip, N. ,  SONI, Ashish, A.

IPC: A61K47/50 ,  A61K49/00 ,  C07D209/00 ,  C07D209/58 ,  C07D209/60

CPC classification number: C09B23/086 ,  A61K49/0034 ,  C07D209/60 ,  C09B67/0092 ,  C09B67/0096

Abstract: The present invention involves an improved process for the preparation of Indocyanine green of Formula (I) having high purity of about 99%, wherein the process comprises steps of reacting 1,1,2-trimethyl-1H-benzo[e]indole with 1,4-butane sulfone in boiling solvent to give 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate. Followed by reacting 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate of Formula (IV) and N-phenyl-N-((1E,3E,5E)-5-(phenylimino)penta-1,3-dienyl)acetamide of formula (V) in presence of sodium acetate and alcohol; and extracting the title compound formula (I) with an ester solvent.

公开(公告)号：EP2393420B1

公开(公告)日：2018-05-30

申请号：EP10739160.9

申请日：2010-02-05

Applicant: Beth Israel Deaconess Medical Center, Inc. ,  Georgia State University Research Foundation, Inc.

Inventor： FRANGIONI, John, V. ,  HENARY, Maged M.

IPC: A61B5/00 ,  A61B6/00 ,  A61K49/00 ,  C07D209/02 ,  C07D209/42 ,  C07D255/02 ,  C09B23/01 ,  C12Q1/02 ,  G01N33/58 ,  C09B23/08

CPC classification number: A61K49/0032 ,  A61B6/00 ,  C07D209/02 ,  C07D209/42 ,  C07D255/02 ,  C09B23/0066 ,  C09B23/086 ,  C12Q1/02 ,  G01N33/582

Abstract: The present invention relates to compositions and methods of optically imaging tissues or cells using imaging agents have in vivo properties that result in signal-to-background ratios of at least about 1:1. TL is a targeting ligand and n is −1, 0 or +1.

公开(公告)号：EP1981846B1

公开(公告)日：2017-11-01

申请号：EP06794328.2

申请日：2006-08-11

Applicant: Laboratoires Synth-Innove

Inventor： SCHERNINSKI, François ,  GUYON, Vincent ,  RAGER, Marie-Noëlle

IPC: C07D209/60

CPC classification number: C09B11/08 ,  C07D209/10 ,  C07D209/60 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D487/22 ,  C07D493/10 ,  C09B23/083 ,  C09B23/086 ,  G01N33/582 ,  G01N33/583 ,  Y10T436/25

公开(公告)号：EP1934211B1

公开(公告)日：2017-01-11

申请号：EP06802829.9

申请日：2006-09-01

Applicant: VisEn Medical, Inc.

Inventor： NARAYANAN, Narasimhachari ,  GROVES, Kevin ,  PETERSON, Jeffrey, D. ,  RAJOPADHYE, Milind

IPC: C07D419/02 ,  C09B23/02 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D209/14 ,  C09B23/01 ,  C09B23/08 ,  G01N33/533 ,  G01N33/58 ,  G01N33/537 ,  A61K49/00

CPC classification number: C09B23/086 ,  A61K49/0032 ,  A61K49/0052 ,  C07D209/14 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C09B23/0066 ,  C09B23/083 ,  G01N33/533 ,  G01N33/537 ,  G01N33/582

Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.

公开(公告)号：EP2298838B1

公开(公告)日：2016-05-04

申请号：EP09754565.1

申请日：2009-05-13

Applicant: Adeka Corporation

Inventor： ISHIDA Tatsuya ,  YANAGISAWA Satoshi ,  MAEDA Yosuke

IPC: C09B67/02 ,  C08K3/34 ,  C08K5/46 ,  C08K5/56 ,  C08L101/00 ,  G02B5/22 ,  C09B45/20 ,  C09B23/01 ,  C09B23/04 ,  C09B23/06 ,  C09B23/08

CPC classification number: G02B5/223 ,  C08K5/0091 ,  C08K5/34 ,  C08K5/46 ,  C08K5/56 ,  C09B23/0066 ,  C09B23/04 ,  C09B23/06 ,  C09B23/083 ,  C09B23/086 ,  C09B45/20 ,  C09B63/00

公开(公告)号：EP2970674A2

公开(公告)日：2016-01-20

申请号：EP14721134.6

申请日：2014-03-14

Applicant: VisEn Medical, Inc.

Inventor： NARAYANAN, Narasimhachari

IPC: C09B23/01 ,  A61K51/00 ,  C09B23/08 ,  G01N21/47 ,  G01N33/52 ,  G01N33/533 ,  G01N33/58

CPC classification number: G01N33/56966 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  A61K51/0446 ,  C07B2200/05 ,  C07D403/08 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C09B23/0066 ,  C09B23/086 ,  G01N33/582

Abstract: The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.

公开(公告)号：EP2850061A4

公开(公告)日：2015-12-09

申请号：EP13758184

申请日：2013-03-02

Applicant: NANOQUANTUM SCIENCES INC

Inventor： JONES GARY W ,  TATARETS ANATOLIY L ,  PATSENKER LEONID D

IPC: C07D209/30 ,  A61K31/404 ,  A61K31/428 ,  A61P31/00 ,  A61P33/00 ,  A61P35/00 ,  A61P43/00 ,  C07D209/10 ,  C07D277/68 ,  C07D293/10 ,  C07D403/06 ,  C07D417/06 ,  C08G61/12 ,  C08G67/00 ,  C09B23/02

CPC classification number: A61K41/0057 ,  A61K31/403 ,  A61K31/404 ,  A61K31/438 ,  A61K41/0071 ,  A61N1/30 ,  A61N5/062 ,  A61N5/10 ,  A61N2005/0659 ,  A61N2005/0663 ,  C07D209/04 ,  C07D209/08 ,  C07D209/10 ,  C07D209/18 ,  C07D209/24 ,  C07D209/58 ,  C07D209/60 ,  C07D277/62 ,  C07D277/64 ,  C07D293/12 ,  C07D401/02 ,  C07D403/06 ,  C07D403/14 ,  C07D417/06 ,  C07D471/10 ,  C07D487/22 ,  C09B23/086 ,  C09B23/105 ,  C09B47/00 ,  C09B62/00

Abstract: Halo-organic heterocyclic compounds are described, which have the formulas Ring A is an aromatic ring bound to at least two halogen atoms, at least one of which is iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications.

Abstract translation: 描述了具有下式的卤代有机杂环化合物：环A是与至少两个卤素原子结合的芳环，其中至少一个是碘或溴。 还描述了基于这些杂环化合物的聚甲基染料，以及这些聚甲炔染料的树枝状大分子化合物和共轭物。 聚甲炔染料的特征在于在诸如光动力学治疗，光动力学抗微生物化学疗法的应用中增强的性质，例如亮度，光稳定性，敏感性和/或选择性亲和力，使其可用于靶向癌细胞，致病微生物和/或其他生物材料 （PACT），癌症治疗，选择性去除或附着生物材料，抗微生物涂层材料以及其他诊断，分析，频谱移位，沉积/生长和分析应用。

公开(公告)号：EP2371904B1

公开(公告)日：2015-11-11

申请号：EP09834661.2

申请日：2009-11-18

Applicant: Adeka Corporation

Inventor： MAEDA Yosuke ,  OTSUKI Ryoya ,  SHIGENO Koichi

IPC: C09B23/00 ,  C07D209/14 ,  C09K3/00 ,  G02B5/22 ,  G09F9/00

CPC classification number: C07D209/14 ,  C09B23/0008 ,  C09B23/0016 ,  C09B23/0033 ,  C09B23/0041 ,  C09B23/0058 ,  C09B23/0066 ,  C09B23/086 ,  G02B5/208

公开(公告)号：EP2535201B1

公开(公告)日：2014-10-15

申请号：EP11170294.0

申请日：2011-06-17

Applicant: Agfa-Gevaert

Inventor： Waumans, Bart ,  Callant, Paul

IPC: B41M3/14 ,  B41M5/26 ,  B41M5/337 ,  B41M7/00 ,  B41M5/327 ,  B41M5/333 ,  B41M5/41 ,  B41M5/44

CPC classification number: B41M3/144 ,  B41J2/442 ,  B41M3/142 ,  B41M5/267 ,  B41M5/327 ,  B41M5/3336 ,  B41M5/3372 ,  B41M5/3375 ,  B41M5/41 ,  B41M5/44 ,  B41M7/009 ,  B41M2205/04 ,  B41M2205/38 ,  B42D25/00 ,  B42D25/29 ,  C09B11/24 ,  C09B23/0008 ,  C09B23/0016 ,  C09B23/0066 ,  C09B23/086 ,  Y10S430/146 ,  Y10T428/24802

公开(公告)号：EP2661469A1

公开(公告)日：2013-11-13

申请号：EP11802452.0

申请日：2011-12-29

Applicant: Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Inventor： BERTHELOT, Thomas ,  ALOUINI, Mohamed Anis ,  ALBENQUE-RUBIO, Sandra ,  DELERIS, Gérard

IPC: C09B23/02 ,  C07C243/30 ,  C07C281/02 ,  G01N33/533 ,  G01N33/58 ,  C07H21/00 ,  C07C243/16 ,  C07C243/40 ,  C09B23/00

CPC classification number: C07C243/40 ,  C07C243/16 ,  C09B23/0066 ,  C09B23/086 ,  C09B69/00

Abstract: The present invention relates to a conjugate of the formula A−R
1 −N (H) −N (CH
2 −C (=O) −R
2 −B)
2 , in which A is a functional entity, B is a targeting entity, and R
1 and R
2 are identical or different and each represent a bond or a group of bonds including from 1 to 40 carbon atoms, in particular 1 to 30 carbon atoms. The present invention also relates to a method for preparing such a conjugate, and to the use thereof in medicine or diagnostics.