公开(公告)号：EP4353741A1

公开(公告)日：2024-04-17

申请号：EP22201705.5

申请日：2022-10-14

申请人： ONK Therapeutics Limited

发明人： The designation of the inventor has not yet been filed

IPC分类号： C07K14/47 ,  A61K35/17 ,  C07K14/705 ,  C12N5/0783

CPC分类号： A61K35/17 ,  C12N5/0646 ,  C12N2510/0020130101 ,  C07K14/7056 ,  C07K14/4718 ,  C07K14/4703

摘要： NK cells and NK cell lines are modified to increase their cytotoxicity, proliferation, metabolic profile and persistence, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to knockout expression of both CISH and NKG2A genes

公开(公告)号：EP3829551B1

公开(公告)日：2024-01-03

申请号：EP19845343.3

申请日：2019-07-29

发明人： SOMMADOSSI, Jean-Pierre ,  MOUSSA, Adel

IPC分类号： C07C55/08 ,  C07C215/60 ,  A61K31/00 ,  A61K31/137 ,  A61K47/12

公开(公告)号：EP4154015A1

公开(公告)日：2023-03-29

申请号：EP21807943.2

申请日：2021-05-18

申请人： Amprion, Inc. ,  Concha, Luis ,  Farris, Carly ,  Holguin, Bret ,  Ma, Yihua

发明人： CONCHA, Luis ,  FARRIS, Carly ,  HOLGUIN, Bret ,  MA, Yihua

IPC分类号： G01N33/68 ,  A61K45/00 ,  A61P25/28

公开(公告)号：EP4142896A1

公开(公告)日：2023-03-08

申请号：EP21796179.6

申请日：2021-04-26

申请人： Neozyme Inernational, Inc.

发明人： DALE, Parker D. ,  JOHNSTON, Jay

IPC分类号： A62D1/00 ,  C12P1/02

公开(公告)号：EP3907355A1

公开(公告)日：2021-11-10

申请号：EP21172080.0

申请日：2021-05-04

申请人： Gatemaster Ltd

发明人： Matthews, Mark ,  Napthine, Simon

IPC分类号： E05B57/00 ,  E05C3/30 ,  E05B15/10

摘要： A hook lock mechanism comprises a hook which pivots about an axis and is movable between at least a position in which it is locked and can act as a dead bolt for a lock and a position in which it is not locked but can act as a latch bolt for a lock. Locks comprising said hook lock mechanism, and methods of locking and unlocking gates with said locks are also disclosed.

公开(公告)号：EP3878950A1

公开(公告)日：2021-09-15

申请号：EP20216695.5

申请日：2015-11-25

申请人： Green Cross Lab Cell Corporation ,  Mogam Institute for Biomedical Research

发明人： MIN, Bo Kyung ,  CHOI, Hana ,  HWANG, Yu Kyeong

IPC分类号： C12N5/0783 ,  C12N5/02 ,  A61K35/14 ,  A61P31/00 ,  A61P35/00 ,  A61K35/17

摘要： The present invention relates to a method for producing natural killer cells using T cells, and more particularly, to a method for producing natural killer cells, which comprises culturing seed cells using CD4(+) T cells as feeder cells. The method for producing natural killer cells using T cells according to the present invention is a method capable of producing natural killer cells by selectively proliferating only natural killer cells from a small amount of seed cells while maintaining the high killing activity of the natural killer cells. The method of the present invention can produce a large amount of natural killer cells that can be frozen, and thus is useful for commercialization of cell therapeutic agents.

公开(公告)号：EP4405048A1

公开(公告)日：2024-07-31

申请号：EP22873866.2

申请日：2022-09-22

申请人： Iolyx Therapeutics, Inc.

发明人： JEFFORDS, Elizabeth W. ,  GUKASYAN, Hovhannes John ,  VERHOEVEN, Rozemarijn ,  HEMMATI, Houman David ,  ESTES, Daniel J.

IPC分类号： A61P27/02 ,  A61K9/10 ,  A61K31/44 ,  A61K31/573

CPC分类号： A61K31/573 ,  A61K31/335 ,  A61P27/02 ,  A61K31/4468

公开(公告)号：EP4355860A1

公开(公告)日：2024-04-24

申请号：EP22735385.1

申请日：2022-06-20

申请人： ONK Therapeutics Limited

发明人： O'DWYER, Michael Eamonn Peter

IPC分类号： C12N5/0783 ,  A61K35/17

CPC分类号： C12N5/0646 ,  C12N2501/59920130101 ,  C12N2510/0020130101 ,  C12N2500/8420130101 ,  C12N2501/231520130101 ,  C12N2501/51520130101 ,  A61K35/17 ,  A61P35/00

公开(公告)号：EP4313866A1

公开(公告)日：2024-02-07

申请号：EP22781743.4

申请日：2022-03-30

申请人： Ecostar-Nautech Co., Ltd

发明人： RIABTSEV, Aleksandr Dmitriyevich ,  NEMKOV, Nikolay Mikhaylovich ,  TITARENKO, Valeriy Ivanovich ,  KURAKOV, Andrey Aleksandrovich ,  LETUEV, Aleksandr Viktorovich

IPC分类号： C01D15/02 ,  C01D15/08 ,  C25B1/34 ,  C25B1/50

公开(公告)号：EP4253412A3

公开(公告)日：2023-11-22

申请号：EP23173594.5

申请日：2016-12-16

申请人： The Walter and Eliza Hall Institute of Medical Research

发明人： HUNTINGTON, Nicholas D. ,  NICHOLSON, Sandra E.

IPC分类号： A61K35/17 ,  A61K38/17 ,  A61K31/7088 ,  A61K39/395 ,  A61P35/00 ,  A61P31/12 ,  A61P37/04 ,  G01N33/566 ,  A61K31/506 ,  A61K31/713 ,  C07K16/18 ,  A61K39/00 ,  A61P35/02 ,  C07K16/28 ,  G01N33/68 ,  C07K16/22

摘要： The present invention relates to therapeutic and prophylactic methods based on inhibition of CIS in NK cells. In particular, the present invention relates to treating or preventing a NK-responsive condition by administering to a subject a CIS inhibitor, or administering CIS-inhibited NK cells. The invention further relates to methods for identifying a CIS inhibitor, and for determining a likelihood of cancer response to treatment with CIS inhibition