公开(公告)号：EP2414360A1

公开(公告)日：2012-02-08

申请号：EP10711972.9

申请日：2010-03-31

申请人： ArQule, Inc.

发明人： TANDON, Manish ,  LIU, Yanbin ,  NAMDEV, Nivedita ,  ASHWELL, Mark, A. ,  PALMA, Rocio

IPC分类号： C07D471/22 ,  A61K31/519 ,  A61P35/00 ,  C07D471/14

CPC分类号： C07D471/22 ,  C07D471/14

摘要： The present invention relates to substituted dipyrido-pyrimido-diazepine compounds of formula (I), substituted benzo-pyrido-pyrimido-diazepine compounds of formula (I) and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted dipyrido-pyrimido-diazepine compounds, substituted benzo-pyrido-pyrimido- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

摘要翻译： 本发明涉及式（I）的取代的二吡啶并 - 嘧啶并二氮杂化合物，式（I）的取代的苯并吡啶并 - 嘧啶并二氮杂化合物和合成这些化合物的方法。 本发明还涉及含有取代的二吡啶并嘧啶二氮杂化合物，取代的苯并吡啶并嘧啶二氮杂化合物和治疗细胞增殖性疾病如癌症的方法的药物组合物，通过将这些化合物和药物组合物给予有需要的受试者 。

公开(公告)号：EP2396003A2

公开(公告)日：2011-12-21

申请号：EP10704696.3

申请日：2010-02-11

申请人： ArQule, Inc. ,  Kyowa Hakko Kirin Co., Ltd.

发明人： CHAN, Thomas C.K. ,  FRANCE, Dennis S. ,  ISHII, Kenichi ,  PUCCI, Paolo

IPC分类号： A61K31/4745 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K31/4745 ,  A61K31/517 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or a pyrroloquinolinyl-pyrrolidine-2,5-dione compound in combination with a therapeutically effective amount of a second anti-proliferative agent.

摘要翻译： 本发明提供了治疗细胞增殖性疾病如癌症的方法，通过向有需要的受试者施用治疗有效量的吡咯并喹啉基 - 吡咯-2,5-二酮化合物或吡咯并喹啉基 - 吡咯烷-2,5 二酮化合物与治疗有效量的第二抗增殖剂组合。

公开(公告)号：EP2389446A1

公开(公告)日：2011-11-30

申请号：EP09839012.3

申请日：2009-07-13

申请人： Massachusetts Institute of Technology ,  The General Hospital Corporation d/b/a Massachusetts General Hospital

发明人： LOVE, John, Christopher ,  VARADARAJAN, Navin ,  JULG, Boris ,  WALKER, Bruce

IPC分类号： C12Q1/02 ,  G01N33/52 ,  G01N33/53 ,  G01N33/563

CPC分类号： G01N33/56972 ,  C40B30/06 ,  G01N33/5047 ,  G01N2333/16

摘要： The invention provides a method of analyzing interactions between pairs of target and effector cells utilizing high-throughput screenings methods for profiling large numbers of single cells in microarrays.

摘要翻译： 本发明提供了一种使用高通量筛选方法分析靶细胞和效应细胞对之间的相互作用的方法，用于在微阵列中分析大量单细胞。

公开(公告)号：EP2370814A2

公开(公告)日：2011-10-05

申请号：EP09799214.3

申请日：2009-12-04

申请人： Massachusetts Institute of Technology

发明人： LOVE, Christopher, J. ,  HAN, Qing ,  TRIPURANENI, Vinay

IPC分类号： G01N33/53

CPC分类号： G01N33/6863 ,  G01N33/5047 ,  G01N33/54366 ,  G01N33/6854

摘要： The invention provides a method for multiple cytokine detection from single cells for the purpose of generating immunological profiles of diseases.

公开(公告)号：EP2350654A2

公开(公告)日：2011-08-03

申请号：EP09822334.0

申请日：2009-10-22

申请人： Allocure, Inc.

发明人： WESTENFELDER, Christof

IPC分类号： G01N33/53 ,  G01N33/564

CPC分类号： G01N33/6893 ,  G01N2333/522 ,  G01N2800/347

公开(公告)号：EP2349332A2

公开(公告)日：2011-08-03

申请号：EP09826827.9

申请日：2009-11-13

申请人： The General Hospital Corporation

发明人： LIN, Herb ,  BABITT, Jodie

IPC分类号： A61K39/395 ,  A61K38/16 ,  A61P7/06

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2319/30

摘要： Modulation of iron homeostasis by regulating BMP-6 activity is provided. Methods of using BMP-6 and BMP-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided. Such antibodies are useful in pharmaceutical compositions for the prevention and treatment of hemochromatosis and anemia of inflammation.

摘要翻译： 提供了一种通过调节BMP-6活性铁稳态的调节。 提供了使用BMP-6和BMP-6蛋白特异性试剂，：如抗体，用于改变在人类中的血清铁水平的方法。 搜索抗体正处于血色素沉着症和炎症性贫血的预防和治疗药物组合物。

公开(公告)号：EP2548583A3

公开(公告)日：2013-02-27

申请号：EP12174847.9

申请日：2006-11-13

申请人： Curagen Corporation

发明人： Tse, Kam Fai ,  Pollack, Vincent A ,  MacDougall, John ,  Shenoy, Suresh G. ,  Mansfield, Traci ,  Lichenstein, Henri ,  Jeffers, Michael E. ,  LaRochelle, William J.

IPC分类号： A61K51/00 ,  G01N33/53 ,  A61K39/395 ,  C07K16/46 ,  A61K47/48 ,  A61K51/10 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

CPC分类号： C07K16/18 ,  A61K47/48469 ,  A61K47/48561 ,  A61K47/48607 ,  A61K47/48638 ,  A61K47/48746 ,  A61K47/6825 ,  A61K47/6849 ,  A61K47/6861 ,  A61K47/6869 ,  A61K47/6897 ,  A61K51/1027 ,  A61K51/106 ,  A61K51/1072 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/3038 ,  C07K16/3069 ,  C07K16/42 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57438 ,  G01N33/57449 ,  G01N2333/705

摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies for the treatment of cancer (e.g., renal and ovarian cancer). In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 though FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

公开(公告)号：EP2548583A2

公开(公告)日：2013-01-23

申请号：EP12174847.9

申请日：2006-11-13

申请人： Curagen Corporation

发明人： Tse, Kam Fai ,  Pollack, Vincent A ,  MacDougall, John ,  Shenoy, Suresh G. ,  Mansfield, Traci ,  Lichenstein, Henri ,  Jeffers, Michael E. ,  LaRochelle, William J.

IPC分类号： A61K51/00 ,  G01N33/53 ,  A61K39/395 ,  C07K16/46 ,  A61K47/48 ,  A61K51/10 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

CPC分类号： C07K16/18 ,  A61K47/48469 ,  A61K47/48561 ,  A61K47/48607 ,  A61K47/48638 ,  A61K47/48746 ,  A61K47/6825 ,  A61K47/6849 ,  A61K47/6861 ,  A61K47/6869 ,  A61K47/6897 ,  A61K51/1027 ,  A61K51/106 ,  A61K51/1072 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/3038 ,  C07K16/3069 ,  C07K16/42 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57438 ,  G01N33/57449 ,  G01N2333/705

摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies for the treatment of cancer (e.g., renal and ovarian cancer). In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 though FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

摘要翻译： 中描述的发明涉及指向抗原TIM-1抗体和寻求治疗癌症的抗体的用途（E. G.，肾癌和卵巢癌）。 特别地，设置有引导至抗原TIM -1完全人单克隆抗体。 分离的多核苷酸序列编码，和氨基酸序列，其包含重链和轻链免疫球蛋白分子，特别是序列对应于连续的重链和轻链序列跨越构架区（FR'S）和/或互补性决定区（CDR'S），具体地从FR1虽然FR4 或CDR1到CDR3，提供。 检验的杂交瘤或表达免疫球蛋白分子的其它细胞系和单克隆抗体因此提供。

公开(公告)号：EP2547795A2

公开(公告)日：2013-01-23

申请号：EP11756928.5

申请日：2011-03-16

申请人： Nanostring Technologies, Inc

发明人： HENGEN, Paul, Nevin ,  GEISS, Gary, K. ,  ELLIOT, Nathan, A. ,  WEBSTER, Phillppa, Jane

IPC分类号： C12Q1/68 ,  C12N15/11

CPC分类号： C12Q1/6816 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6834 ,  C12Q1/6841 ,  C12Q2523/303 ,  C12Q2537/16 ,  C12Q2565/102 ,  C12Q2537/125 ,  C12Q2537/143 ,  C12Q2539/107 ,  C12Q2563/155 ,  C12Q2563/179

摘要： The invention provides compositions and methods for the detection of gene copy number and/or chromosome copy number in a multiplexed reaction. The assays and kits described herein are applicable for the identification, diagnosing, and monitoring of disorders including, but not limited to cancer, developmental and degenerative disease, neurological disorders, and stem cell disorders.

公开(公告)号：EP2543250A1

公开(公告)日：2013-01-09

申请号：EP12187508.2

申请日：2008-02-19

申请人： President and Fellows of Harvard College ,  The United States Government as Represented by the Department of Veterans Affairs

发明人： Thatte, Hemant ,  Treanor, Patrick ,  Khuri, Shukri ,  Rousou, Laki

IPC分类号： A01N1/02

CPC分类号： A01N1/02 ,  A01N1/0226

摘要： Methods and compositions for resuscitating, storing, and preserving -functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function, cardiomyocyte contractility, prevention of acidosis, inhibition of induction of apoptosis, maintaining ionontrophy and lusiotrophy by regulating calcium, sodium, potassium and chloride ions.

摘要翻译： 用于复苏，储存和保存器官和组织的完整功能的方法和组合物。 代谢功能通过维持ATP水平，线粒体功能，心肌细胞收缩力，预防酸中毒，抑制细胞凋亡诱导，通过调节钙离子，钠离子，钾离子和氯离子维持离子萎缩和lusiotrophy来维持。