公开(公告)号：EP3108251B1

公开(公告)日：2018-04-11

申请号：EP15706914.7

申请日：2015-02-12

Applicant: Biomérieux

Inventor： BEDIN, Frédéric ,  FRAGNOUD, Romain

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  G01N2333/185 ,  G01N2333/522 ,  G01N2333/535 ,  G01N2333/81 ,  G01N2800/52 ,  Y02A50/53

公开(公告)号：EP3134730A4

公开(公告)日：2018-01-17

申请号：EP15782996

申请日：2015-04-24

Applicant: IMMUSANT INC

Inventor： ANDERSON ROBERT P

IPC: A61K38/10 ,  A61P1/00

CPC classification number: A61K39/0008 ,  A61K38/168 ,  A61K2039/55 ,  A61K2039/577 ,  C07K7/06 ,  C07K7/08 ,  C07K14/55 ,  G01N33/5091 ,  G01N33/564 ,  G01N33/6863 ,  G01N33/6893 ,  G01N2333/415 ,  G01N2333/521 ,  G01N2333/522 ,  G01N2333/55 ,  G01N2333/57 ,  G01N2800/06 ,  G01N2800/50

Abstract: Provided herein are methods and kits for assaying antigen-specific T cell responses, such as rare autoantigen-specific T cell responses, by measuring a level of IP-10 in a sample from a subject having or suspected of having an autoimmune disease, an allergy, an infectious disease or condition, or an adverse immune condition caused by administration of an isolated, recombinant or synthetic protein or peptide. Also provided herein are methods and kits for assaying a T cell response to an antigen peptide, such as an islet autoantigen peptide, such as measuring a T cell response to at least one antigen peptide, such as an islet autoantigen peptide, in a sample from a subject, such as one having or suspected of having Type 1 Diabetes (TID), Celiac disease or both.

公开(公告)号：EP3250927A2

公开(公告)日：2017-12-06

申请号：EP16704525.1

申请日：2016-01-28

Applicant: F. Hoffmann-La Roche AG

Inventor： TOWNSEND, Michael ,  SETIADI, Alvernia Francesca ,  STATON, Tracy

IPC: G01N33/564

CPC classification number: C12Q1/6883 ,  A61K2039/505 ,  C07K16/244 ,  C07K2317/76 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/564 ,  G01N2333/47 ,  G01N2333/522 ,  G01N2333/535 ,  G01N2333/5412 ,  G01N2333/5421 ,  G01N2333/8146 ,  G01N2800/285 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present invention concerns markers of multiple sclerosis, their use, and treatment with IL-17 antagonists, including IL-17 antibodies, of subjects with increased levels of such markers.

公开(公告)号：EP2720043B1

公开(公告)日：2016-01-20

申请号：EP14150638.6

申请日：2011-03-10

Applicant: INSTITUT PASTEUR

Inventor： Gougeon, Marie-Lise ,  Poirier-Beaudouin, Béatrice ,  Seffer, Valérie ,  Saidi, Héla

IPC: G01N33/569 ,  G01N33/68

CPC classification number: G01N33/6896 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/15 ,  A61B5/4029 ,  A61B5/4064 ,  A61B5/407 ,  A61B5/4082 ,  A61B5/4088 ,  A61B2010/0077 ,  G01N33/56988 ,  G01N33/6854 ,  G01N2333/16 ,  G01N2333/52 ,  G01N2333/522 ,  G01N2333/523 ,  G01N2800/28 ,  G01N2800/56

Abstract: The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a HIV-infected subject, and the use of this method to monitor the human immunodeficiency virus (HIV) infection of a subject who is known to be infected with HIV. The invention also concerns a prognostic method of the state of progression of Acquired immune deficiency syndrome (AIDS) or the state of progression toward AIDS, in particular the state of progression or the state of progression toward neurological disorders associated with AIDS. Finally, the invention is also about method to determine the immune deficiency or level of immune activation of a HIV-infected patient.

公开(公告)号：EP2946214A1

公开(公告)日：2015-11-25

申请号：EP14704011.7

申请日：2014-01-21

Applicant: AbbVie Inc.

Inventor： VOSS, Jeffrey, W. ,  CUFF, Carolyn, A.

IPC: G01N33/68 ,  G01N33/50

CPC classification number: G01N33/6863 ,  A61K39/3955 ,  C12Q1/6883 ,  G01N2333/522 ,  G01N2333/525 ,  G01N2333/54 ,  G01N2800/52

Abstract: The invention provides methods for predicting the efficacy of anti-TNF and anti- IL17 combination therapies in the treatment of a subject suffering from inflammatory disease by determining the level CXCL1 and/or CXCL5 markers in a sample derived from the subject.

公开(公告)号：EP2652507A2

公开(公告)日：2013-10-23

申请号：EP11848773.5

申请日：2011-12-13

Applicant: Morehouse School of Medicine

Inventor： LILLARD, James, W. ,  SINGH, Shailesh ,  SINGH, Rajesh

IPC: G01N33/574 ,  G01N33/68 ,  G01N33/53

CPC classification number: G01N33/57496 ,  C07K16/24 ,  C07K16/2866 ,  C07K2317/73 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57426 ,  G01N33/5743 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/521 ,  G01N2333/522 ,  G01N2333/7158 ,  G01N2800/52

Abstract: Methods for detecting cancer in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprise CCL25 or CCR9 or both CCL25 and CCR9.

公开(公告)号：EP2531620A1

公开(公告)日：2012-12-12

申请号：EP11740468.1

申请日：2011-02-04

Applicant: Astute Medical, Inc.

Inventor： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

IPC: C12Q1/68 ,  G01N33/567

CPC classification number: G01N33/6893 ,  G01N33/6863 ,  G01N33/86 ,  G01N2333/4745 ,  G01N2333/522 ,  G01N2333/96447 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Coagulation factor VII, CA 19-9, Insulin-like growth factor-binding protein 7, C-X-C motif chemokine 6, and C-C motif chemokine 13 as diagnostic and prognostic biomarkers in renal injuries.

Abstract translation: 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用一种或多种配置为检测选自凝血因子VII，CA 19-9，胰岛素样生长因子结合蛋白7，CXC基序趋化因子6， 和CC基序趋化因子13作为肾损伤中的诊断和预后生物标志物。

公开(公告)号：EP2144064A3

公开(公告)日：2010-05-26

申请号：EP09171902.1

申请日：2005-10-04

Applicant: Akers Biosciences, Inc.

Inventor： Milunic, David ,  Andrelczyk, Susan

IPC: G01N33/543

CPC classification number: G01N33/6863 ,  B01L3/5023 ,  B01L2200/16 ,  B01L2300/0681 ,  B01L2400/0683 ,  G01N33/54313 ,  G01N33/564 ,  G01N33/6893 ,  G01N33/86 ,  G01N2333/522 ,  G01N2400/40 ,  G01N2800/222

Abstract: Methods for determining the presence of heparin/platelet factor 4 antibodies in a sample suspected to contain heparin/platelet factor 4 antibodies are provided, along with apparatus suitable for performing the methods. Preferred methods comprise contacting the sample with particles being complexed to platelet factor 4 (PF4) and which particle-complexed PF4 reacts specifically with heparin/platelet factor 4 antibodies, passing the sample/particle mixture through a filter, and then analyzing the color of the filtrate.

公开(公告)号：EP1962092A3

公开(公告)日：2008-11-12

申请号：EP08010722.0

申请日：2005-12-09

Applicant: Renovar, Inc.

Inventor： Hu, Huaizhong ,  Knechtle, Stuart ,  Aizenstein, Brian D.

IPC: G01N33/53 ,  G01N33/68 ,  G01N33/574 ,  G01N33/74

CPC classification number: G01N33/6863 ,  G01N33/57442 ,  G01N33/6893 ,  G01N2333/522 ,  G01N2333/70578 ,  G01N2333/715 ,  G01N2800/245 ,  G01N2800/347 ,  G01N2800/60

Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.

公开(公告)号：EP1962092A2

公开(公告)日：2008-08-27

申请号：EP08010722.0

申请日：2005-12-09

Applicant: Renovar, Inc.

Inventor： The designation of the inventor has not yet been filed

IPC: G01N33/53 ,  G01N33/68 ,  G01N33/574 ,  G01N33/74

CPC classification number: G01N33/6863 ,  G01N33/57442 ,  G01N33/6893 ,  G01N2333/522 ,  G01N2333/70578 ,  G01N2333/715 ,  G01N2800/245 ,  G01N2800/347 ,  G01N2800/60

Abstract: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the efficacy of agents and interventions used to treat kidney disorders.

Abstract translation: 本发明涉及诊断，预测和监测肾脏疾病的方法。 特别地，本发明涉及通过检测尿中的细胞因子，细胞因子相关化合物和趋化因子来诊断，预测和监测肾脏疾病。 本发明还涉及用于评估用于治疗肾脏疾病的药剂和干预措施的功效的方法和组合物。