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31.发明公开SENSE OLIGONUCLEOTIDE CAPABLE OF CONTROLLING THE EXPRESSION OF iNOS AND COMPOSITION COMPRISING THE SAME 有权与控制能力iNOS和综合该组合物的表达义寡核苷酸
公开(公告)号：EP2031057A1
公开(公告)日：2009-03-04
申请号：EP07744893.4
申请日：2007-06-07
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/43 , A61K48/00 , A61P1/00 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P19/02 , A61P25/00 , A61P25/02 , A61P29/00 , A61P31/04 , A61P43/00
CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/3233
摘要： The invention relates to sense oligonucleotide having a sequence complementary to a single-stranded RNA (antisense transcript) having a sequence complementary to mRNA of iNOS gene in order to control expression of iNOS (inducible nitric oxide synthase). The sense oligonucleotide of the present invention can control expression of iNOS and is useful for biological defense and treatment and prevention of diseases related to excessive production of NO, such as cancerogenesis, inflammatory disease, endotoxin shock by bacterial infection and the like.
摘要翻译： 本发明涉及用于感测具有一个互补的序列的单链RNA（反义转录物）为了控制iNOS表达（诱导型一氧化氮合成酶），其具有与iNOS基因的mRNA互补的序列的寡核苷酸。 本发明的正义寡核苷酸可以控制iNOS表达，并且是生物防御和治疗和预防与过度产生NO引起的疾病：如致癌，炎性疾病，内毒素休克的细菌感染等。
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32.发明公开HEALTH FOOD AND PHARMACEUTICAL COMPOSITION FOR AMELIORATION OF DISEASE INDUCED BY METABOLIC DISORDER IN CARTILAGE 审中-公开健康食品和药物组合物，疾病方面，因代谢紊乱软骨的救济
公开(公告)号：EP1897551A1
公开(公告)日：2008-03-12
申请号：EP06746005.5
申请日：2006-05-02
发明人： UCHIDA, Atsumasa , WAKAME, Koji c/o Amino Up Chemical Co., Ltd. , ISHIDA, Tsuyoshi c/o Ishida Pharma Corporation
IPC分类号： A61K38/17 , A61K31/352 , A61K31/353 , A61K31/7008 , A61K31/7048 , A61P19/02 , A61P19/08 , A61P29/00 , A23L1/30 , A23L1/305 , A23L1/333
CPC分类号： A61K38/17 , A23L33/10 , A23L33/105 , A23L33/28 , A61K31/352 , A61K31/353 , A61K31/7008 , A61K31/7048
摘要： The invention relates to a health food and a pharmaceutical preparation, containing a composition for treating rheumatoid arthritis. The health food and pharmaceutical preparation in which glucosamine, a collagen and an isoflavone aglycone act synergically, which are useful for relieving symptoms or treatment of diseases related to abnormal cartilage metabolism, especially rheumatoid arthritis.
摘要翻译： 本发明涉及一种保健食品和药物制剂，包含用于治疗类风湿性关节炎的组合物。 在其中葡糖胺的保健食品和药物制剂，拼贴和协同地的异黄酮苷元的行为，这是缓解症状或治疗与异常软骨代谢，爱特别是类风湿性关节炎疾病。
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33.发明公开METHOD OF PRODUCING PROANTHOCYANIDIN OLIGOMER 审中-公开VERFAHREN ZUR HERSTELLUNG EINES PROANTHOCYANIDIN OLIGOMERS
公开(公告)号：EP1852430A1
公开(公告)日：2007-11-07
申请号：EP06714541.7
申请日：2006-02-24
发明人： TANAKA, Takashi , NONAKA, Gen-ichiro , KOHNO, Isao , FUJII, Hajime, c/o Amino Up Chemical Co., Ltd. , NAKAGAWA, Takashi, c/o Amino Up Chemical Co., Ltd. , NISHIOKA, Hiroshi c/o Amino Up Chemical Co., Ltd.
IPC分类号： C07D311/62 , A61P39/06 , A61P43/00
CPC分类号： A61K31/353 , A61K8/498 , A61K36/04 , A61K36/14 , A61K36/15 , A61K36/185 , A61K36/45 , A61K36/485 , A61K36/54 , A61K36/61 , A61K36/73 , A61K36/734 , A61K36/74 , A61K36/77 , A61K36/82 , A61K36/87 , A61K36/88 , A61K36/889 , A61K2800/522 , A61Q19/08 , C07D311/62 , A61K2300/00
摘要： The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.
摘要翻译： 本发明涉及含有原花色素聚合物或其提取物的含有原花青素聚合物或其提取物的含有原花青素环结构或间苯二酚环结构的物质作为其主要成分的分子量的组合物， 在酸性水溶液中具有间苯三酚环结构或间苯二酚环结构的物质，其制备方法以及保健品和药品中的组合物的用途。 根据本发明，具有生理活性的具有间苯三酚环结构或间苯二酚环结构的物质的原花色素寡聚物已经结合并分子量降低至低聚物可以吸收到生物体中的水平 通常难以从植物原料获得高产率，可以有效且容易地生产。
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34.发明公开NOVEL SUBSTANCE ORIGINATING IN BASIDIOMYCETE CULTURE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF 有权OFF担子菌文化起源物质，工艺生产同样及其用途
公开(公告)号：EP1154022A4
公开(公告)日：2004-06-09
申请号：EP00981704
申请日：2000-12-14
发明人： KOSUNA KEN-ICHI , YUAN LAN , MIURA TAKEHITO , SUN BUXIANG
IPC分类号： A23K1/00 , A23K1/16 , A23L1/30 , A61K31/352 , C12P17/06
CPC分类号： A61K36/074 , A23K10/12 , A23K20/121 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/07 , C12P17/06 , A23V2250/21172
摘要： A novel substance which is obtained by culturing a basidiomycete having a β-glucosidase activity in a medium having a material containing isoflavones, comprises the aglycons of the isoflavones and the culture product of the basidiomycete, and has synergistically enhanced physiological activity of the aglycons of the isoflavones with physiological activity of the basidiomycete; and foods, feeds and drugs containing the same. Because of having the synergistically enhanced physiological activity of the aglycons of the isoflavones and the physiological activity of the culture product of the basidiomycete, the above-described substance is useful not only as an antitumor agent but also as a remedy and/or preventive for osteoporosis and an immunopotentiating agent.
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35.发明公开NOVEL SUBSTANCE HAVING PHYSIOLOGICAL ACTIVITY, PROCESS FOR PRODUCING THE SAME, AND USE 有权具有生理活性，处理新的物质用于生产和它们的用途
公开(公告)号：EP1298137A1
公开(公告)日：2003-04-02
申请号：EP01955626.5
申请日：2001-08-09
发明人： FUJII, Hajime, Amino Up Chemical Co., Ltd. , NAKAGAWA, Takashi, Amino Up Chemical Co., Ltd. , SUN, Buxiang, Amino Up Chemical Co., Ltd.
摘要： A glucoside containing isomaltol represented by formula (I):
(wherein Sug represents a glucose residue or a sugar linkage composed of two or more glucose units) as an aglycon, a physiologically active substance containing the glucoside having human cytokine inducing ability increasing activity, a method for producing it, and food, medicine and feedstuff containing the substance.-
36.发明公开NOVEL SUBSTANCE ORIGINATING IN BASIDIOMYCETE CULTURE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF 有权OFF担子菌文化起源物质，工艺生产同样及其用途
公开(公告)号：EP1154022A1
公开(公告)日：2001-11-14
申请号：EP00981704.0
申请日：2000-12-14
发明人： KOSUNA, Ken-Ichi, c/o Amino Up Chemical Co., Ltd , YUAN, Lan, c/o Amino Up Chemical Co., Ltd , MIURA, Takehito, c/o Amino Up Chemical Co., Ltd , SUN, Buxiang, c/o Amino Up Chemical Co., Ltd
IPC分类号： C12P17/06 , A23L1/30 , A23K1/16 , A61K31/352 , A61P35/00
CPC分类号： A61K36/074 , A23K10/12 , A23K20/121 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/07 , C12P17/06 , A23V2250/21172
摘要： A novel substance that has the physiological activity of the aglycone of isoflavones and the physiological activity of the culture of the basidiomycetes with the physiological activities being synergistically enhanced, obtained by cultivating a basidiomycetes having a β-glucosidase activity in a medium containing an isoflavone, a method for producing it, and food, feedstuff and medicine containing it.
The substance of the invention is improved in the physiological effect of the aglycone of isoflavones and the physiological effect of the culture of the basidiomycetes, and is not only useful as an anti-tumor agent but also is useful for therapy and/or prevention of osteoporosis and also as an immune enhancement agent.摘要翻译： 一种新颖的物质确实已经异黄酮苷元和与所述生理活性的担子菌的培养物的生理活性的生理活性被协同增强，通过培养具有在介质中的β-葡糖苷酶活异黄酮的含，一个一个担子菌获得 制造方法是，与食品，饲料和药品含有它。 本发明的物质中的异黄酮糖苷配基和担子菌的培养物的生理作用的生理效果提高，并且不只是作为抗肿瘤剂有用的，但这样是用于治疗和/或预防骨质疏松症的有用 并以免疫增强剂。
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公开(公告)号：EP0733647A3
公开(公告)日：1997-05-02
申请号：EP95307113.1
申请日：1995-10-06
发明人： Kosuna, Kenichi
CPC分类号： C08B37/0006 , C12P19/04
摘要： A novel polysaccharide comprising (1->4) bonded α-D-glucose units represented by the following formula
wherein R is a hydrogen atom or an acetyl group in the ratio of ca. 7:3 is extracted and isolated from a liquid culture medium of a microorganism belonging to the genus Basidiomycetes in the presence of a plant tissue raw material. About 30% by mole of hydroxyl groups at the 2,3-positions of each unit is acetylated and the polysaccharide has a molecular weight of 500 to 10,000. The polysaccharide has properties of biological response modifiers (BRM) and is useful as an immuno-enhancing agent or immuno-activator.-
公开(公告)号：EP0733647A2
公开(公告)日：1996-09-25
申请号：EP95307113.1
申请日：1995-10-06
发明人： Kosuna, Kenichi
CPC分类号： C08B37/0006 , C12P19/04
摘要： A novel polysaccharide comprising (1->4) bonded α-D-glucose units represented by the following formula
wherein R is a hydrogen atom or an acetyl group in the ratio of ca. 7:3 is extracted and isolated from a liquid culture medium of a microorganism belonging to the genus Basidiomycetes in the presence of a plant tissue raw material. About 30% by mole of hydroxyl groups at the 2,3-positions of each unit is acetylated and the polysaccharide has a molecular weight of 500 to 10,000. The polysaccharide has properties of biological response modifiers (BRM) and is useful as an immuno-enhancing agent or immuno-activator.摘要翻译： 一种新型多糖，其包含由下式（CHEM）表示的（1-> 4）键合的α-D-葡萄糖单元，其中R为氢原子或乙酰基， 在植物组织原料存在下，从属于担子菌纲的微生物的液体培养基中提取和分离7:3。 每单位2,3位上约30摩尔％的羟基被乙酰化，多糖的分子量为500〜10000。 多糖具有生物反应调节剂（BRM）的特性，可用作免疫增强剂或免疫激活剂。
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