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    CELL DIFFERENTIATION INDUCER AND DIFFERENTIATION INDUCING METHOD
    34.
    发明公开
    CELL DIFFERENTIATION INDUCER AND DIFFERENTIATION INDUCING METHOD 审中-公开
    细胞分化诱导和分化诱导方法

    公开(公告)号：EP2711419A1

    公开(公告)日：2014-03-26

    申请号：EP12784895.0

    申请日：2012-05-14

    申请人： The University of Tokushima

    发明人： TSUJI, Daisuke ,  ITOH, Kohji ,  SANO, Shigeki ,  NAKAO, Michiyasu

    IPC分类号： C12N5/0793 ,  A61K31/166 ,  A61K31/203 ,  A61K31/235 ,  A61K31/277 ,  A61K31/426 ,  A61P25/00 ,  A61P43/00

    CPC分类号： C12N5/0618 ,  C12N2501/385 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/45

    摘要： The objective of the present invention is to provide a cell differentiation inducer which is a low-molecular compound, which can be chemically synthesized easily and which can efficiently induce a differentiation of an undifferentiated cell into a nervous system cell with high selectivity. In addition, the objective of the present invention is to provide use of a specific catechol derivative for efficiently inducing a differentiation of an undifferentiated cell into a nervous system cell with high selectivity, and a method for efficiently inducing a differentiation of an undifferentiated cell into a nervous system cell with high selectivity using a specific catechol derivative. The cell differentiation inducer of the present invention is characterized in comprising the catechol derivative having the specific chemical structure.

    摘要翻译： 本发明的目的是提供一种细胞分化诱导剂，它是一种低分子化合物，其可以容易地化学合成，并且可以高选择性地有效诱导未分化细胞向神经系统细胞的分化。 另外，本发明的目的在于提供特异性儿茶酚衍生物以高选择率有效诱导未分化细胞分化为神经系统细胞的用途，以及有效诱导未分化细胞分化为 神经系统细胞具有高选择性使用特定的儿茶酚衍生物。 本发明的细胞分化诱导剂的特征在于包含具有特定化学结构的儿茶酚衍生物。

    PROCESS FOR PREPARATION OF DIETHYLENETRIAMINEPENTAACETIC ACID DERIVATIVES, AND DIETHYLENETRIAMINEPENTAACETIC ACID DERIVATIVES
    35.
    发明公开
    PROCESS FOR PREPARATION OF DIETHYLENETRIAMINEPENTAACETIC ACID DERIVATIVES, AND DIETHYLENETRIAMINEPENTAACETIC ACID DERIVATIVES 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON二乙烯 - 三聚氰胺-PENTA-ESSIGSÄURE-DERIVATEN SOWIE二乙烯 - 三聚氰胺-PENTA-ESSIGSÄURE-DERIVATE

    公开(公告)号：EP2489655A1

    公开(公告)日：2012-08-22

    申请号：EP10823275.2

    申请日：2010-09-22

    申请人： The University of Tokushima

    发明人： NEMOTO, Hisao ,  KAWAMURA, Tomoyuki ,  YATSUZUKA, Kenji ,  KAMIYA, Masaki

    IPC分类号： C07C227/16 ,  C07C229/30 ,  C07C233/47 ,  C07C271/08 ,  C07C271/12 ,  C07D207/452

    CPC分类号： C07D207/452 ,  C07C227/16 ,  C07C233/47 ,  C07C271/08 ,  C07C271/12 ,  C07C229/30

    摘要： The objective of the present invention is to provide a process for simple and efficient preparation of an intermediate compound to synthesize a gadolinium complex having a substituent for improving a retention property in blood time and specificity to an intended organ. The objective of the present invention is also to provide an intermediate compound produced by the said production process. The process for preparation of the diethylenetriaminepentaacetic acid derivative (I):

    wherein R 1 to R 5 are independently C 1-6 alkyl groups;
    comprising the steps of:
    reacting a diethylenetriaminepentaacetic acid pentaester with a halogenated ally compound in an aprotic solvent;
    removing the excess halogenated ally compound (III); and
    reacting a reaction product of the diethylenetriaminepentaacetic acid pentaester and the halogenated ally compound with a base in a solvent.

    摘要翻译： 本发明的目的是提供简单有效地制备中间体化合物以合成具有取代基的钆络合物的方法，以提高对血液时间的保留性和对预期器官的特异性。 本发明的目的还在于提供通过所述制备方法制备的中间体化合物。 制备二亚乙基三胺五乙酸衍生物（I）的方法：其中R 1至R 5独立地为C 1-6烷基; 包括以下步骤：使二亚乙基三胺五乙酸五酯与卤素化合物在非质子溶剂中反应; 除去过量的卤代烯化合物（III）; 并将二亚乙基三胺五乙酸五酯与卤代烯化合物的反应产物与碱在溶剂中反应。

    ULTRAVIOLET STERILIZATION DEVICE FOR OUTDOOR WATER
    37.
    发明公开
    ULTRAVIOLET STERILIZATION DEVICE FOR OUTDOOR WATER 有权
    紫外线杀菌剂FERR WASSER IM AUSSENBEREICH

    公开(公告)号：EP2394963A1

    公开(公告)日：2011-12-14

    申请号：EP09827388.1

    申请日：2009-11-21

    申请人： The University of Tokushima ,  Silver Making Co., Ltd.

    发明人： TAKAHASHI, Akira ,  KINOUCHI, Yohsuke ,  AKUTAGAWA, Masatake

    IPC分类号： C02F1/32 ,  A01K63/04 ,  H01L33/00

    CPC分类号： A01K63/04 ,  C02F1/325 ,  C02F2103/007 ,  C02F2201/3221 ,  C02F2201/3222 ,  C02F2201/3225 ,  C02F2201/3227 ,  Y02W10/37

    摘要： [Problem to be solved] To kill bacteria with ultraviolet light that can effectively kill bacteria with ultraviolet light and to suppress bacteria increase due to photoreactivation after disinfection.
    [Means to solve the problem] Bacteria in water 9 exposed outdoors are effectively killed with ultraviolet (UV) light by suppressing post-treatment increase in the bacteria population due to photoreactivation. The apparatus shines UV light on the water 9 to kill bacteria and has UV light emitting diodes (LEDs) 1 that emit UVA light with a primary emission peak of 320nm-400nm. The antibacterial action of the UVA light emitted by the UV LEDs 1 prevents proliferation of bacteria in the disinfected water 9 due to photoreactivation.

    摘要翻译： [待解决的问题]用紫外线杀死细菌，可以用紫外线有效杀灭细菌，抑制消毒后光活化引起的细菌增多。 [解决问题的方法]通过抑制由于光活化而导致的细菌群体的后处理增加，室外暴露于水中的细菌9被紫外线（UV）光有效地杀死。 该装置将UV光照射在水9上以杀死细菌，并且具有发射具有320nm-400nm的主发射峰的UVA光的UV发光二极管（LED）1。 由UV LED1发出的UVA光的抗菌作用防止由于光激活而在消毒水9中细菌的增殖。

    Method of predicting risk of acquiring influenza
    39.
    发明公开
    Method of predicting risk of acquiring influenza 有权
    Verfahren zur Vorhersage des Risikos einer Infizierung mit Influenza

    公开(公告)号：EP2161576A1

    公开(公告)日：2010-03-10

    申请号：EP09011204.6

    申请日：2009-09-01

    申请人： Fujifilm Corporation ,  The University of Tokushima

    发明人： Kido, Hiroshi ,  Terashima, Kaoru

    IPC分类号： G01N33/53 ,  G01N33/569

    CPC分类号： G01N33/6854 ,  G01N33/56983 ,  G01N33/582 ,  G01N2333/11 ,  G01N2800/50

    摘要： An object of the present invention is to provide a method for predicting the risk of acquiring influenza, which is characterized by low price, low invasiveness, and applicability to total automation. The present invention provides a method for predicting the risk of acquiring influenza, which comprises measuring the ratio of anti-influenza IgA to the total IgA in a specimen collected from a subject.

    摘要翻译： 本发明的目的是提供一种用于预测感冒风险的方法，其特征在于价格低，侵入性低，适用于全自动化。 本发明提供一种预测获得流感的风险的方法，其包括测量从受试者收集的样本中抗流感IgA与总IgA的比例。

    LIGHT EMITTING DIODE AND METHOD OF FABRICATING THE SAME
    40.
    发明公开
    LIGHT EMITTING DIODE AND METHOD OF FABRICATING THE SAME 有权
    发光二极管与制造VEFAHREN

    公开(公告)号：EP2149162A1

    公开(公告)日：2010-02-03

    申请号：EP08753522.5

    申请日：2008-05-16

    申请人： Seoul Opto Device Co., Ltd. ,  The University of Tokushima

    发明人： SAKAI, Shiro ,  NAOI, Yoshiki

    IPC分类号： H01L33/00

    CPC分类号： H01L33/22 ,  H01L33/0095 ,  H01L33/44

    摘要： The present invention provides a method of fabricating a light emitting diode, which comprises the steps of forming a compound semiconductor layer on a substrate, the compound semiconductor layer including a lower semiconductor layer, an active layer and an upper semiconductor layer; and scratching a surface of the substrate by rubbing the substrate with an abrasive. According to the present invention, the abrasive is used to rub and scratch the surface of the light emitting diode, thereby making it possible to cause the light emitted from the active layer to effectively exit to the outside. Therefore, the light extraction efficiency of the light emitting diode can be improved.