公开(公告)号：EP1859041A1

公开(公告)日：2007-11-28

申请号：EP05770546.9

申请日：2005-07-21

申请人： Angiochem Inc.

发明人： BELIVEAU, Richard ,  DEMEULE, Michel ,  CHE, Christian ,  REGINA, Anthony

IPC分类号： C12N15/15 ,  C07K14/81 ,  A61K47/48 ,  A61K47/42 ,  A61K51/08 ,  A61K49/14 ,  A61P25/00

CPC分类号： A61K47/48246 ,  A61K31/337 ,  A61K38/00 ,  A61K39/44 ,  A61K47/64 ,  A61K2039/505 ,  C07K14/8117 ,  Y10S977/915

摘要： The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as conjugates and pharmaceutical compositions comprising these polypeptides or conjugates. The present invention also relates to the use of these polypeptide for transporting a compound or drug across the blood-brain barrier of a mammal and in the treatment and diagnosis of neurological diseases.