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公开(公告)号：EP3078753A1
公开(公告)日：2016-10-12
申请号：EP16167704.2
申请日：2011-05-09
IPC分类号： C12Q1/68 , C12N9/22 , C12N15/55 , C12Q1/34 , G01N33/573
CPC分类号： C12Q1/6823 , C07K1/22 , C07K14/8117 , C12N9/22 , C12N15/1003 , C12P19/34 , C12Q1/6806 , C12Q1/6816 , C12Q2521/313
摘要： The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.
摘要翻译： 本公开内容提供了变体Csy4内切核糖核酸酶，编码变体Csy4内切核糖核酸酶的核酸以及用该核酸遗传修饰的宿主细胞。 变体Csy4内切核糖核酸酶可用于各种应用中，其也提供。 本公开还提供了检测靶多聚核糖核苷酸中的特定序列的方法; 以及调节真核细胞中靶RNA产生的方法。
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公开(公告)号：EP2917244A1
公开(公告)日：2015-09-16
申请号：EP13853308.8
申请日：2013-11-12
申请人： Angiochem Inc.
CPC分类号： A61K38/57 , A61K47/6811 , A61K47/6843 , A61K47/6849 , A61K47/6855 , A61K47/6889 , C07K14/8117 , C07K2319/00
摘要： The present invention relates to protein conjugates comprising an aprotinin-derived polypeptide, which facilitates transport of the conjugate across the blood-brain barrier, and an antibody moiety that selectively binds a target within the CNS. The protein conjugates are further defined by the inclusion of a linker; by the number of polypeptides conjugated to each antibody moiety; by the positions at which the antibody moiety and the polypeptides are conjugated; and by the larger configuration of the conjugate (in which every polypeptide is linked only to the antibody moiety). Modified aprotinin-derived polypeptides, linker-bound antibody moieties, pharmaceutical compositions, kits, and methods of making and using the protein conjugates are also features of the invention.
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3.发明授权Aprotinin polypeptides for transporting a compound across the blood-brain barrier 有权Aprotininpolypeptide用于跨血脑屏障输送化合物
公开(公告)号：EP2360258B1
公开(公告)日：2014-10-08
申请号：EP11000946.1
申请日：2005-07-21
申请人： Angiochem Inc.
CPC分类号： A61K47/48246 , A61K31/337 , A61K38/00 , A61K39/44 , A61K47/64 , A61K2039/505 , C07K14/8117 , Y10S977/915
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4.发明公开
公开(公告)号：EP2569425A2
公开(公告)日：2013-03-20
申请号：EP11781086.1
申请日：2011-05-09
IPC分类号： C12N9/22 , C12N15/55 , C12Q1/34 , C12Q1/68 , G01N33/573
CPC分类号： C12Q1/6823 , C07K1/22 , C07K14/8117 , C12N9/22 , C12N15/1003 , C12P19/34 , C12Q1/6806 , C12Q1/6816 , C12Q2521/313
摘要： The present disclosure provides variant Csy4 endoribonucleases, nucleic acids encoding the variant Csy4 endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Csy4 endoribonucleases find use in a variety of applications, which are also provided. The present disclosure also provides methods of detecting a specific sequence in a target polyribonucleotide; and methods of regulating production of a target RNA in a eukaryotic cell.
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5.发明授权APROTININ POLYPEPTIDES FOR TRANSPORTING A COMPOUND ACROSS THE BLOOD-BRAIN BARRIER 有权APROTININPOLYPEPTIDE交通连接通血 - 脑屏障
公开(公告)号：EP1859041B1
公开(公告)日：2012-03-28
申请号：EP05770546.9
申请日：2005-07-21
申请人： Angiochem Inc.
CPC分类号： A61K47/48246 , A61K31/337 , A61K38/00 , A61K39/44 , A61K47/64 , A61K2039/505 , C07K14/8117 , Y10S977/915
摘要： The invention relates to improvements in the field of drug delivery. More particularly, the invention relates to polypeptides derived from aprotinin and from aprotinin analogs as well as conjugates and pharmaceutical compositions comprising these polypeptides or conjugates. The present invention also relates to the use of these polypeptide for transporting a compound or drug across the blood-brain barrier of a mammal and in the treatment and diagnosis of neurological diseases.
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公开(公告)号：EP0859852B1
公开(公告)日：2008-09-17
申请号：EP96942722.8
申请日：1996-10-31
申请人： Prodigene, Inc.
发明人： HOWARD, John, A. , BASZCYNSKI, Chris , CZAPLA, Thomas , HOOD, Elizabeth , MEYER, Terry, EuClaire , PETERSON, David , RAO, A., Gururaj , REGISTER, James, C., III , WITCHER, Derrick
CPC分类号： C07K14/8117 , C12N15/8257 , C12N15/8286 , Y02A40/162
摘要： A method for commercial production of aprotinin entails heterologous expression of the protein in plants, preferably at a level such that aprotinin accounts for at least 0.1% of the total extracted protein. An aprotinin-expressing plant also has potential of increased insecticidal resistance by virtue of producing the protein. A genetic map of the integration locus allows identification of plants derived from the transgenic plant. This approach also reveals genetic loci on a plant chromosome that support high levels of gene expression and can be used as site of integration for expression of other genes of interest.
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公开(公告)号：EP1752538A1
公开(公告)日：2007-02-14
申请号：EP06010363.7
申请日：1997-03-10
申请人： BAYER CORPORATION
发明人： Tamburini, Paul P. , Delaria, Katherine A. , Muller, Daniel K. , Davis, Gary , Marlor, Christopher W.
CPC分类号： C07K14/8117 , A61K38/00 , C07K14/8114
摘要： The instant invention provides for proteins, polypeptides, nucleic acid sequences, constructs, expression vectors, host cells, pharmaceutical compositions of, and methods for using human placental bikunin, serine protease inhibitor domains, and fragments thereof.
摘要翻译： 本发明提供蛋白质，多肽，核酸序列，构建体，表达载体，宿主细胞，药物组合物和使用人胎盘比肯宁，丝氨酸蛋白酶抑制物结构域及其片段的方法。
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公开(公告)号：EP1335931B1
公开(公告)日：2005-12-21
申请号：EP01931843.5
申请日：2001-05-14
CPC分类号： C12N9/0065 , C07K1/1077 , C07K14/62 , C07K14/8117 , C07K16/00 , C12Y111/01006
摘要： Proteins are derivatised by reaction of pendant groups, usually groups which are side chains in non-terminal amino acyl units of the protein, in aqueous reactions in the presence of a denaturant. The denaturant is preferably an amphiphilic compound, most preferably an anionic amphiphilic compound such as a long chain alkyl sulphate mono ester, preferably an alkaline metal salt, for instance sodium dodecyl sulphate. The degree of derivatisation is increased, whilst the protein retains activity, such as enzyme activity. The increase in the degree of derivatisation enhances the increase in circulation time in vivo and stability on storage and in vivo. Preferably the derivatising reagent is an aldehyde compound which reacts with primary amine groups, generally the epsilon-amino group of lysyl units. Derivatisation is conducted under reducing conditions to generate a secondary amine derivative.
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">9.发明公开Kallikrein-inhibiting "Kunitz Domain" proteins and nucleic acids encoding the same 失效激肽释放酶抑制“Kunitz结构域”的蛋白质的核酸编码
公开(公告)号：EP1484339A3
公开(公告)日：2005-03-02
申请号：EP04019920.0
申请日：1995-01-11
申请人： Dyax Corporation
CPC分类号： C07K14/8117 , A61K38/00 , C07K14/8114 , G01N2333/8114 , G01N2333/96455
摘要： This invention relates to nucleic acids encoding novel BPTI-homologous Kunitz domains, especially LACI homologues, which inhibit one or more plasma (and/or tissue) kallikreins, and to the therapeutic and diagnostic use of these novel proteins. In particular, the Kunitz domains are derived from Kunitz domains of human origin and especially to the first Kunitz domain of LACI. Additionally, the invention relates to recombinant expression vectors comprising a nucleic acid according to the invention, methods for producing a kallikrein binding domain, isolated polypeptides comprising a Kunitz domain structure, pharmaceutical compositions thereof as well as the use of the same and methods of assaying the presence of kallikrein or of purifying kallikrein.
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公开(公告)号：EP0859852A1
公开(公告)日：1998-08-26
申请号：EP96942722.0
申请日：1996-10-31
申请人： Prodigene
发明人： HOWARD, John, A. , BASZCYNSKI, Chris , CZAPLA, Thomas , HOOD, Elizabeth , MEYER, Terry, EuClaire , PETERSON, David , RAO, A., Gururaj , REGISTER, James, C., III , WITCHER, Derrick
CPC分类号： C07K14/8117 , C12N15/8257 , C12N15/8286 , Y02A40/162
摘要： A method for commercial production of aprotinin entails heterologous expression of the protein in plants, preferably at a level such that aprotinin accounts for at least 0.1% of the total extracted protein. An aprotinin-expressing plant also has potential of increased insecticidal resistance by virtue of producing the protein. A genetic map of the integration locus allows identification of plants derived from the transgenic plant. This approach also reveals genetic loci on a plant chromosome that support high levels of gene expression and can be used as site of integration for expression of other genes of interest.
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