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公开(公告)号：EP2507235B1
公开(公告)日：2014-10-22
申请号：EP10787274.9
申请日：2010-11-17
发明人： SCHULZE, Volker , KOPPITZ, Marcus , KOSEMUND, Dirk , SCHIROK, Hartmut , BADER, Benjamin , LIENAU, Philip , WENGNER, Antje, Margret , BRIEM, Hans , HOLTON, Simon , SIEMEISTER, Gerhard , PRECHTL, Stefan , BÖMER, Ulf
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A61K2300/00
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32.发明授权SULFOXIMINSUBSTITUIERTE ANILINOPYRIMIDINDERATIVE ALS CDK-INHIBITOREN, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZEINMITTEL 有权磺胺嘧啶取代的苯胺基吡啶作为CDK抑制剂，它们的制备和用作药物
公开(公告)号：EP2350026B1
公开(公告)日：2014-06-18
申请号：EP09778874.9
申请日：2009-10-09
IPC分类号： C07D239/47 , A61K31/505 , A61P35/00
CPC分类号： C07D239/47
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公开(公告)号：EP2714692A1
公开(公告)日：2014-04-09
申请号：EP12729041.9
申请日：2012-05-30
发明人： EIS, Knut , PÜHLER, Florian , ZORN, Ludwig , SCHOLZ, Arne , LIENAU, Philip , GNOTH, Mark Jean , BÖMER, Ulf , GÜNTHER, Judith , FANGHÄNEL, Jörg , KORR, Daniel
IPC分类号： C07D487/04 , C07D519/00 , A61K31/5025 , A61P35/00
CPC分类号： A61K31/5025 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present invention relates to substituted aminoimidazopyridazine compounds of general formula (I) : in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的取代的氨基咪唑并哒嗪化合物：其中A，R 1，R 2，R 3和R 4如权利要求中所定义，涉及制备所述化合物的方法，药物组合物和包含所述化合物的组合， 所述化合物用于制造用于治疗或预防疾病，特别是过度增殖和/或血管发生病症的药物组合物作为单独药剂或与其他活性成分组合的用途。
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公开(公告)号：EP2699575A1
公开(公告)日：2014-02-26
申请号：EP12721779.2
申请日：2012-04-16
发明人： SCHULZE, Volker , KOSEMUND, Dirk , WENGNER, Antje, Margret , SIEMEISTER, Gerhard , STÖCKIGT, Detlef , LIENAU, Philip , SCHIROK, Hartmut , BRIEM, Hans
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： The present invention relates to triazolopyridine compounds of general formula (I) : in which R
1 , R
2 , R
3 , R
4 , and R
5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.-
公开(公告)号：EP2507233B1
公开(公告)日：2013-11-06
申请号：EP10782198.5
申请日：2010-11-17
发明人： SCHULZE, Volker , KOPPITZ, Marcus , KOSEMUND, Dirk , BADER, Benjamin , LIENAU, Philip , BRIEM, Hans , HOLTON, Simon , SIEMEISTER, Gerhard , PRECHTL, Stefan , WENGNER, Antje, Margret
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
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36.发明公开6 SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS 审中-公开6-取代的咪唑并吡嗪FOR USE AS MPS-1和TKK抑制剂用于过度增殖性疾病的治疗
公开(公告)号：EP2651950A1
公开(公告)日：2013-10-23
申请号：EP11797314.9
申请日：2011-12-13
发明人： KOPPITZ, Marcus , KLAR, Ulrich , JAUTELAT, Rolf , KOSEMUND, Dirk , BOHLMANN, Rolf , BADER, Benjamin , LIENAU, Philip , SIEMEISTER, Gerhard
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to substituted imidazopyrazine compounds of general formula (I) in which R
1 , R
2 , R
3 , R
4 and R
5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.-
37.发明公开2-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS 有权2-取代的咪唑并吡嗪FOR USE AS MPS-1和TKK抑制剂用于过度增殖性疾病的治疗
公开(公告)号：EP2651946A1
公开(公告)日：2013-10-23
申请号：EP11794490.0
申请日：2011-12-13
发明人： KOPPITZ, Marcus , KLAR, Ulrich , JAUTELAT, Rolf , KOSEMUND, Dirk , BOHLMANN, Rolf , BADER, Benjamin , LIENAU, Philip , SIEMEISTER, Gerhard
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to substituted imidazopyrizine compounds of general formual (I): in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP2723748B1
公开(公告)日：2016-10-12
申请号：EP12733002.5
申请日：2012-06-21
发明人： EIS, Knut , PÜHLER, Florian , ZORN, Ludwig , SCHOLZ, Arne , LIENAU, Philip , GNOTH, Mark, Jean , BÖMER, Ulf , GÜNTHER, Judith , FANGHÄNEL, Jörg , KORR, Daniel
IPC分类号： C07D487/04 , A61K31/425 , A61P35/00
CPC分类号： C07D487/04
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39.发明授权SULFONSUBSTITUIERTE ANLINOPYRIMIDINDERIVATIVE ALS CDK-INHIBITOREN, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL 有权SULFONSUBSTITUIERTE ANLINOPYRIMIDINDERIVATIVE作为CDK抑制剂的，生产与应用，药物
公开(公告)号：EP2342185B1
公开(公告)日：2016-01-13
申请号：EP09778863.2
申请日：2009-10-08
IPC分类号： C07D239/47 , A61K31/505 , A61P35/00
CPC分类号： C07D239/47
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40.发明授权2-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS 有权2-取代的咪唑并吡嗪FOR USE AS MPS-1和TKK抑制剂用于过度增殖性疾病的治疗
公开(公告)号：EP2651946B1
公开(公告)日：2015-05-27
申请号：EP11794490.0
申请日：2011-12-13
发明人： KOPPITZ, Marcus , KLAR, Ulrich , JAUTELAT, Rolf , KOSEMUND, Dirk , BOHLMANN, Rolf , BADER, Benjamin , LIENAU, Philip , SIEMEISTER, Gerhard
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04
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