公开(公告)号：EP2710004A1

公开(公告)日：2014-03-26

申请号：EP12721826.1

申请日：2012-05-14

申请人： Bayer Intellectual Property GmbH

发明人： EIS, Knut ,  PÜHLER, Florian ,  ZORN, Ludwig ,  SCHOLZ, Arne ,  LIENAU, Philip ,  GNOTH, Mark, Jean ,  BÖMER, Ulf ,  GÜNTHER, Judith ,  FANGHÄNEL, Jörg ,  KORR, Daniel

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/5025 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K31/5377 ,  C07D519/00

摘要： The present invention relates to amino imidazopyridazine compounds of general formula (I): in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said 10 compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

公开(公告)号：EP2723748B1

公开(公告)日：2016-10-12

申请号：EP12733002.5

申请日：2012-06-21

申请人： Bayer Intellectual Property GmbH

发明人： EIS, Knut ,  PÜHLER, Florian ,  ZORN, Ludwig ,  SCHOLZ, Arne ,  LIENAU, Philip ,  GNOTH, Mark, Jean ,  BÖMER, Ulf ,  GÜNTHER, Judith ,  FANGHÄNEL, Jörg ,  KORR, Daniel

IPC分类号： C07D487/04 ,  A61K31/425 ,  A61P35/00

CPC分类号： C07D487/04

公开(公告)号：EP2714692A1

公开(公告)日：2014-04-09

申请号：EP12729041.9

申请日：2012-05-30

申请人： Bayer Intellectual Property GmbH

发明人： EIS, Knut ,  PÜHLER, Florian ,  ZORN, Ludwig ,  SCHOLZ, Arne ,  LIENAU, Philip ,  GNOTH, Mark Jean ,  BÖMER, Ulf ,  GÜNTHER, Judith ,  FANGHÄNEL, Jörg ,  KORR, Daniel

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/5025 ,  A61P35/00

CPC分类号： A61K31/5025 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

摘要： The present invention relates to substituted aminoimidazopyridazine compounds of general formula (I) : in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

摘要翻译： 本发明涉及通式（I）的取代的氨基咪唑并哒嗪化合物：其中A，R 1，R 2，R 3和R 4如权利要求中所定义，涉及制备所述化合物的方法，药物组合物和包含所述化合物的组合， 所述化合物用于制造用于治疗或预防疾病，特别是过度增殖和/或血管发生病症的药物组合物作为单独药剂或与其他活性成分组合的用途。

公开(公告)号：EP2714692B1

公开(公告)日：2017-03-22

申请号：EP12729041.9

申请日：2012-05-30

申请人： Bayer Intellectual Property GmbH

发明人： EIS, Knut ,  PÜHLER, Florian ,  ZORN, Ludwig ,  SCHOLZ, Arne ,  LIENAU, Philip ,  GNOTH, Mark Jean ,  BÖMER, Ulf ,  GÜNTHER, Judith ,  FANGHÄNEL, Jörg ,  KORR, Daniel

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/5025 ,  A61P35/00

CPC分类号： A61K31/5025 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

公开(公告)号：EP2723748A1

公开(公告)日：2014-04-30

申请号：EP12733002.5

申请日：2012-06-21

申请人： Bayer Intellectual Property GmbH

发明人： EIS, Knut ,  PÜHLER, Florian ,  ZORN, Ludwig ,  SCHOLZ, Arne ,  LIENAU, Philip ,  GNOTH, Mark, Jean ,  BÖMER, Ulf ,  GÜNTHER, Judith ,  FANGHÄNEL, Jörg ,  KORR, Daniel

IPC分类号： C07D487/04 ,  A61K31/425 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The present invention relates to heterocyclyl aminoimidazopyridazine compounds of general formula (I) : in which A, R1, R2, R3 and R4 are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

摘要翻译： 本发明涉及通式（I）的杂环基氨基咪唑并哒嗪化合物：其中A，R 1，R 2，R 3和R 4如权利要求中所定义，涉及制备所述化合物的方法，药物组合物和包含所述化合物的组合， 所述化合物用于制造用于治疗或预防疾病，特别是过度增殖和/或血管发生病症的药物组合物作为单独药剂或与其他活性成分组合的用途。