公开(公告)号：EP1007079A1

公开(公告)日：2000-06-14

申请号：EP98909981.7

申请日：1998-01-23

申请人： Epimmune Inc.

发明人： SETTE, Alessandro ,  SIDNEY, John ,  SOUTHWOOD, Scott

IPC分类号： A61K38/08 ,  A61K38/10 ,  A61K39/10 ,  A61K39/02 ,  A61K39/12 ,  C07K7/00 ,  C07K14/005 ,  C07K14/20 ,  C07K14/195 ,  C07K14/725 ,  C07H21/04

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/001 ,  C07K14/445 ,  C07K14/70539 ,  C12N2730/10122 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2770/24222 ,  C12N2770/24244 ,  G01N33/56977 ,  G01N2333/70539 ,  Y02A50/401 ,  Y02A50/412 ,  Y02A50/57 ,  Y10S530/868

摘要： The present invention is based on peptide binding specificities of HLA DR4w4, DR1 and DR7. Peptides binding to these DR molecules have a motif characterized by a large aromatic or hydrophobic residue in position 1 (Y, F, W, L, I, V, M) and a small, non charged residue in position 6 (S, T, C, A, P, V, I, L, M). In addition, allele-specific secondary effects and secondary anchors are defined, and these results were utilized to derive allele specific algorithms. By the combined use of such algorithms peptides capable of degenerate DR1, 4, 7 binding were identified.