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公开(公告)号：EP1320377B1
公开(公告)日：2011-03-23
申请号：EP00961444.7
申请日：2000-09-01
申请人： Epimmune Inc.
CPC分类号： C07K14/005 , C07K14/445 , C07K14/4746 , C07K14/4748 , C07K14/71 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , Y02A50/412
摘要： The present invention provides peptide compositions capable of binding glycoproteins encoded by HLA, HLA-B, and HLA-C alleles and inducing T cell activation in T cells restricted by the HLA allele. The peptides are useful to elicit an immune response against a desired antigen.
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公开(公告)号：EP0703783B1
公开(公告)日：2010-05-05
申请号：EP94910837.7
申请日：1994-03-04
申请人： Epimmune Inc.
CPC分类号： C07K14/005 , A61K38/00 , C07K14/70539 , C12N2730/10122 , C12N2770/24222
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公开(公告)号：EP1089757A1
公开(公告)日：2001-04-11
申请号：EP99928792.3
申请日：1999-06-17
申请人： Epimmune, Inc.
IPC分类号： A61K39/145 , C07K7/06
CPC分类号： C07K14/70539 , A61K38/00
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA alleles and inducing T cell activation in T cells restricted by the allele. The peptides are useful to elicit an immune response against a desired antigen.
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4.发明公开PEPTIDES AND PEPTIDE-LOADED ANTIGEN PRESENTING CELLS FOR THE ACTIVATION OF CTL 失效肽和用肽LOADED，抗原呈递细胞毒性T细胞的活化
公开(公告)号：EP1012238A1
公开(公告)日：2000-06-28
申请号：EP98906086.8
申请日：1998-01-30
申请人： Epimmune, Inc.
发明人： TSAI, Van , SOUTHWOOD, Scott , SIDNEY, John , SETTE, Alessandro , CELIS, Esteban
CPC分类号： C12N5/0636 , A61K39/0011 , A61K2039/5158 , A61K2039/57 , C12N2501/23 , C12N2502/11 , Y02A50/412
摘要： Methods for generating antigen-specific cytotoxic T lymphocytes (CTLs) in vitro are presented in conjuntion with methods for using these CTLs for therapy in vivo. The antigen presenting cells (APCs) used herein notably include dentritic cells pretreated with GM-CSF and IL-4. Antigen-specific CTLs were obtained by incubating CD8 preparations in the presence of APCs that bound desired peptides. IL-7 was generally added at day 1 of the incubation; IL-10 was generally added one day later and during restimulation. The invention also comprises methods for using peptide pulsed dentritic cells to identify novel MHC Class I-restricted tumor antigens and subdominant epitopes.
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公开(公告)号：EP0907370A1
公开(公告)日：1999-04-14
申请号：EP97918494.0
申请日：1997-03-21
申请人： Epimmune, Inc.
CPC分类号： C07K14/005 , A61K39/00 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded by HLA-A2.1 allele and inducing T cell activation in T cells restricted by the A2.1 allele. The peptides are useful to elicit an immune response against a desired antigen.
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6.发明授权PEPTIDES WITH INCREASED BINDING AFFINITY FOR AT LEAST THREE HLA-A3-LIKE MOLECULES 失效以增加的亲和力肽绑定至少三HLA-A3样分子
公开(公告)号：EP0914142B9
公开(公告)日：2012-01-04
申请号：EP97914975.4
申请日：1997-03-10
申请人： Epimmune Inc.
IPC分类号： A61K38/03 , A61K39/002 , A61K39/02 , A61K39/12
摘要： Ther present invention provides immunogenic peptides comprising an HLA-A3 supermotif. The peptides can be used to treat, diagnose, or monitor a number of pathological conditions.
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公开(公告)号：EP1578432A2
公开(公告)日：2005-09-28
申请号：EP03768519.5
申请日：2003-10-03
申请人： Epimmune Inc.
IPC分类号： A61K31/711 , A61K38/00 , C07H21/04 , C07K7/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/35 , C07K14/4746 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/70539 , C07K14/82 , C07K2319/01 , C12N2710/16222 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2770/24222
摘要： Provided herein are peptides in certian pathogens and/or human or murine proteins that are identified as capable of binding one or more MHC molecules and inducing an immume response in a system. Also provided are compositions that include one or more of the peptides and methods for inducing an immune reponse in a system by administering the compositions to the system.
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公开(公告)号：EP1368659A2
公开(公告)日：2003-12-10
申请号：EP02709233.7
申请日：2002-01-29
申请人： Epimmune, Inc.
IPC分类号： G01N33/68 , G01N33/569 , C07K14/00
CPC分类号： G01N33/6812 , G01N2500/04
摘要： Methods to design vaccines which are effective in individuals bearing A2 supertype alleles are described. Single amino acid substitution analogs of known A2-supertype binding peptides, and large peptide libraries were utilized to rigorously define the peptide binding specificities of A2-supertype molecules. While each molecule was noted to have unique preferences, large overlaps in specificity were found. The presence of the hydrophobic and aliphatic residues L, I, V, M, A, T, and Q in positon 2 of peptide ligands was commonly tolerated by A2-supertype molecules. L, I, V, M, A, and T were tolerated at the C-terminus. While examination of secondary influences on peptide binding revealed allele specific preferences, shared features could also be identified, and were utilized to define an A2-supermotif. Shared features also correlate with cross-reactivity; over 70% of the peptides that bound A*0201 with high affinity were found to bind at least 2 other A2-supertype molecules. Finally, the coefficients for use in the development of algorithms for the prediction of peptide binding to A2-supertype molecules are provided.
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公开(公告)号：EP1343819A1
公开(公告)日：2003-09-17
申请号：EP00964938.5
申请日：2000-09-01
申请人： Epimmune Inc.
CPC分类号： C07K14/005 , A61K39/0011 , A61K2039/57 , C12N9/90 , C12N2730/10122 , C12N2740/16222 , C12N2760/16122 , C12N2770/24222
摘要： The present invention provides the means and methods for selecting immunogenic peptides and the immunogenic peptide compositions capable of specifically binding glycoproteins encoded HLA-A2.1 allele and inducing T cell activation in T cells restricted by the A2.1 allele. The peptides are useful to elicit an immune response against a desired antigen.
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10.发明公开
公开(公告)号：EP1242049A1
公开(公告)日：2002-09-25
申请号：EP00986510.6
申请日：2000-12-13
申请人： Epimmune Inc.
发明人： FIKES, John , SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott , CELIS, Esteban , KEOGH, Elissa , CHESNUT, Robert
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K45/06 , C07K14/4748 , C07K14/705 , C07K14/70539
摘要： A composition or vaccine composition comprising at least one peptide that has less than 600 contiguous amino acids having 100 % identity to a native sequence of CEA, HER2/neu, MAGE2, MAGE3, or p53, the peptide further comprising at least one epitope selected from Table 6.
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