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61 条记录 (耗时 0.022 秒)

    USE OF A FLUORESCENT MATERIAL TO DETECT FAILURE OR DETERIORATED PERFORMANCE OF A FLUOROMETER
    31.
    发明公开
    USE OF A FLUORESCENT MATERIAL TO DETECT FAILURE OR DETERIORATED PERFORMANCE OF A FLUOROMETER 审中-公开
    荧光材料用于识别故障或性能干扰的荧光USE

    公开(公告)号：EP2861963A1

    公开(公告)日：2015-04-22

    申请号：EP13732308.5

    申请日：2013-06-07

    申请人： Gen-Probe Incorporated

    发明人： LI, Haitao ,  OPALSKY, David ,  HEINZ, R., Eric ,  HAGEN, Norbert, D.

    IPC分类号： G01N21/27 ,  G01N21/64

    摘要： A System and method for self-checking a fluorometer for failure or deteriorated performance includes fluorescent reference standards mounted on a support to move with respect to one or more fixed fluorometers. The intensity of the fluorescent emission of the fluorescent reference standard is initially measured with the fluorometer, and, after a prescribed interval of usage of the fluorometer, a test measurement of the intensity of the fluorescent emission of the fluorescent standard is taken with the fluorometer. The test measurement is compared to the initial measurement, and failure or deteriorated performance of the fluorometer is determined based on a deviation of the test measurement from the initial measurement.

    METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES
    35.
    发明公开
    METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES 审中-实审

    公开(公告)号：EP4372366A2

    公开(公告)日：2024-05-22

    申请号：EP24168644.3

    申请日：2016-06-08

    申请人： Gen-Probe Incorporated

    发明人： HAGEN, Norbert ,  OPALSKY, David ,  WALKER, George T. ,  KNIGHT, Byron J.

    IPC分类号： G01N21/64

    CPC分类号： G01N21/276 ,  G01N21/645

    摘要： There is described a method for calibrating or monitoring performance of an optical measurement device using an optical reference material that emits a reference emission: (a) moving, using a robotic arm, a first reference device comprising an optical reference material into a signal-detecting position of the optical measurement device; (b) detecting, using the optical measurement device, an emission emitted by the optical reference material of the first reference device in the signal-detecting position; (c) generating a reference signal representing a characteristic of the emission detected by the optical measurement device; and (d) comparing the reference signal to an expected reference signal for the emission to calibrate or monitor the performance of the optical measurement device; preferably, wherein the optical measurement device comprises a fluorometer.

    SYSTEMS AND METHODS FOR READING MACHINE-READABLE MARKS ON RACKS AND RECEPTACLES
    37.
    发明公开
    SYSTEMS AND METHODS FOR READING MACHINE-READABLE MARKS ON RACKS AND RECEPTACLES 审中-实审

    公开(公告)号：EP4336403A2

    公开(公告)日：2024-03-13

    申请号：EP24153425.4

    申请日：2016-10-24

    申请人： Gen-Probe Incorporated

    发明人： OPALSKY, David

    IPC分类号： G06K7/10

    摘要： A sample processing or assay instrument includes a moveable support. The moveable support defines a first pocket configured to receive a first object having a first machine-readable mark. The moveable support defines a second pocket configured to receive a second object having a second machine-readable mark. The moveable support also includes a first fiducial machine-readable mark and a second fiducial machine-readable mark. The instrument also includes an image capture device that captures a first image including the first fiducial machine-readable mark and the first machine-readable mark of the first object. The image capture device captures a second image that includes the second fiducial machine-readable mark and the second machine-readable mark of the second object. The instrument also includes a processor configured to associate information decoded from the first and second machine-readable marks with first and second locations on the moveable support.

    SYSTEM, METHOD, AND APPARATUS FOR AUTOMATED INCUBATION
    38.
    发明公开
    SYSTEM, METHOD, AND APPARATUS FOR AUTOMATED INCUBATION 审中-公开

    公开(公告)号：EP4309790A2

    公开(公告)日：2024-01-24

    申请号：EP23214994.8

    申请日：2013-07-31

    申请人： Gen-Probe Incorporated

    发明人： BUSE, David ,  COMBS, David ,  HAGEN, Norbert ,  OPALSKY, David ,  RICHARDSON, Bruce ,  PRASAD, Anita ,  MORAVICK, Keith ,  MOORE, Tyler ,  KNIGHT, Byron J.

    IPC分类号： B01L3/00

    摘要： There is disclosed an apparatus comprising: a receptacle holder comprised of a heat-conducting material and including a plurality of receptacle wells, wherein each receptacle well is configured to receive a receptacle therein and includes a through-hole extending from an inner surface of the receptacle well to an outer surface of the receptacle holder; a plurality of optical fibers, each optical fiber having first and second ends, wherein the first end is in optical communication with one of the receptacle wells, and the second end is in optical communication with at least one of an excitation signal source and an emission signal detector, wherein the first end of each optical fiber is disposed outside or within, or extends through, a corresponding through-hole in each receptacle well, and wherein the first end of each optical fiber is moveable within the corresponding through-hole relative to the surface of the receptacle well; one or more thermal elements positioned proximal to the receptacle holder for altering a temperature or temperatures of the receptacle holder, wherein the thermal element is positioned proximal to a side surface of the receptacle holder, and provides thermal energy through the receptacle holder to each of the plurality of receptacle wells; one or more support(s), each positioned proximal to the side surface of the receptacle holder, wherein the one or more thermal elements are positioned between the support and the receptacle holder, and wherein the support comprises a heat sink, or the support is provided in thermal communication with a heat sink; and one or more thermal devices disposed within the heat sink for pre-heating the heat sink.

    METHOD OF MEASURING AT LEAST ONE TIME-VARYING SIGNAL EMISSION FROM THE CONTENTS OF A RECEPTACLE
    39.
    发明公开
    METHOD OF MEASURING AT LEAST ONE TIME-VARYING SIGNAL EMISSION FROM THE CONTENTS OF A RECEPTACLE 审中-公开

    公开(公告)号：EP3940369A2

    公开(公告)日：2022-01-19

    申请号：EP21195541.4

    申请日：2014-03-07

    申请人： Gen-Probe Incorporated

    发明人： OPALSKY, David ,  HAGEN, Norbert D

    IPC分类号： G01N21/25 ,  G01N21/64

    摘要： There is disclosed a method of measuring at least one time-varying signal emission from the contents of a receptacle while the contents are subject to repeated cycles of temperature variations within a thermal cycling range, the method comprising: measuring the signal emission from the contents of the receptacle at repeating intervals of time and recording the signal emission measurement and a time stamp at each interval; recording a time stamp for each temperature of the thermal cycling range; and synchronizing the signal emission to a specific temperature within the thermal cycling range by comparing time stamps of the signal emission measurements to a time stamp for each temperature of the thermal cycling range.

    SYSTEM AND METHOD FOR MONITORING THE PERFORMANCE OF AN OPTICAL SIGNAL DETECTOR
    40.
    发明公开
    SYSTEM AND METHOD FOR MONITORING THE PERFORMANCE OF AN OPTICAL SIGNAL DETECTOR 审中-公开

    公开(公告)号：EP3764079A1

    公开(公告)日：2021-01-13

    申请号：EP20171886.3

    申请日：2016-12-22

    申请人： Gen-Probe Incorporated

    发明人： OPALSKY, David ,  RAGHUWANSHI, Srajan ,  BUI, James

    IPC分类号： G01N21/03 ,  G01N21/64 ,  G01N21/75 ,  G01N21/27

    摘要： A system for measuring optical signal detector performance includes an optical signal detector comprising a first detection channel having a first light source and a first sensor. The first detection channel is configured to emit and focus light generated by the first light source at a first detection zone, and to receive and focus light on the first sensor. The system also includes a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector based on at least one of (i) a first measured characteristic of light focused on the sensor while a first non-fluorescent surface portion is in the first detection zone and (ii) a second measured characteristic of light focused on the sensor while a void is in the first detection zone. The optical signal detector can be a fluorometer.