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公开(公告)号：EP2968492A1
公开(公告)日：2016-01-20
申请号：EP14718296.8
申请日：2014-03-17
CPC分类号： C07K16/40 , A61K35/17 , A61K39/0011 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K14/70514 , C07K14/70517 , C07K2317/622 , C07K2319/30
摘要： The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing an antigen recognizing receptor and an inhibitory chimeric antigen receptor (iCAR). Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
摘要翻译： 本发明提供表达抗原识别受体和抑制性嵌合抗原受体（iCAR）的免疫应答细胞，包括T细胞，细胞毒性T细胞，调节性T细胞和天然杀伤（NK）细胞。 使用免疫应答细胞的方法包括用于治疗需要增加抗原特异性免疫应答的瘤形成和其他病理的细胞。
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32.发明公开CONSTITUTIVE EXPRESSION OF COSTIMULATORY LIGANDS ON ADOPTIVELY TRANSFERRED T LYMPHOCYTES 有权辅助转化的T淋巴细胞的成员配体的本质表达
公开(公告)号：EP2141997A1
公开(公告)日：2010-01-13
申请号：EP08742463.6
申请日：2008-03-31
IPC分类号： A01N63/00
CPC分类号： A61K35/17 , A61K38/2013 , A61K38/217 , A61K39/0011 , A61K45/06 , A61K2035/122 , A61K2035/124 , A61K2039/5156 , A61K2039/5158 , C12N5/0636 , C12N7/00 , C12N15/85 , C12N2501/25 , C12N2501/51 , C12N2501/599 , C12N2510/00 , C12N2799/04
摘要： The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
摘要翻译： 本发明提供了表达至少一种抗原识别受体和共刺激配体的免疫应答细胞，包括T细胞，细胞毒性T细胞，调节性T细胞和自然杀伤（NK）细胞，以及因此用于 治疗需要增加抗原特异性免疫应答的瘤形成和其他病理。
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公开(公告)号：EP1287357A2
公开(公告)日：2003-03-05
申请号：EP01939874.2
申请日：2001-06-01
IPC分类号： G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： G01N33/56977 , A61K39/0011 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C12N5/0656 , C12N2510/00 , G01N33/505 , G01N33/567 , G01N33/56972 , G01N2333/70539 , G01N2500/20
摘要： The invention provides an artificial antigen presenting cell (AAPC) comprising a eukaryotic cell expressing an antigen presenting complex comprising a human leukocyte antigen (HLA) molecule of a single type, at least one exogenous accessory molecule and at least one exogenous T cell-specific epitope. Methods of use for activation of T lymphocytes are also provided.
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公开(公告)号：EP4453021A2
公开(公告)日：2024-10-30
申请号：EP22912465.6
申请日：2022-12-22
申请人： Memorial Sloan-Kettering Cancer Center , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases
发明人： SADELAIN, Michel , PERICA, Karlo
IPC分类号： C07K14/705 , C07K14/725 , C07K14/525 , A61K38/00
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公开(公告)号：EP4452298A2
公开(公告)日：2024-10-30
申请号：EP22912464.9
申请日：2022-12-22
申请人： Memorial Sloan-Kettering Cancer Center , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases
IPC分类号： A61K38/17 , A61P37/02 , A61K39/395 , C07K19/00 , A61P35/00
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公开(公告)号：EP4438115A2
公开(公告)日：2024-10-02
申请号：EP24178429.7
申请日：2015-09-04
发明人： SADELAIN, Michel , RIVIERE, Isabelle , MANSILLA-SOTO, Jorge , WANG, Xiuyan , STAMATOYANNOPOULOS, George , STAMATOYANNOPOULOS, John , LIU, Mingdong
IPC分类号： A61P7/06
CPC分类号： C07K14/805 , C12N9/22 , C12N15/86 , C12N2740/1504320130101 , C12N2830/4020130101 , C12N2740/1604320130101 , C12N2830/1520130101 , C12N2830/4820130101 , C12N2830/5020130101 , A61K48/0058 , C12N15/85 , C12N2830/00820130101 , C12N2830/3020130101 , C12N2830/4620130101 , A61K48/0066 , A61P7/06
摘要： The presently disclosed subject matter provides for expression cassettes that allow for expression of a globin gene or a functional portion thereof, vectors comprising thereof, and cells transduced with such expression cassettes and vectors. The presently disclosed subject matter further provides methods for treating a hemoglobinopathy in a subject comprising administering an effective amount of such transduced cells to the subject.
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公开(公告)号：EP4352106A1
公开(公告)日：2024-04-17
申请号：EP22821080.3
申请日：2022-06-10
申请人： Memorial Sloan-Kettering Cancer Center , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases , Tri-institutional Therapeutics Discovery Institute, Inc.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
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公开(公告)号：EP4351602A1
公开(公告)日：2024-04-17
申请号：EP22821086.0
申请日：2022-06-10
申请人： Memorial Sloan Kettering Cancer Center , Sloan-Kettering Institute for Cancer Research , Memorial Hospital for Cancer and Allied Diseases
IPC分类号： A61K35/17 , A61K39/395 , C07K14/705 , C07K16/28 , C07K19/00 , C12N5/0783
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公开(公告)号：EP4098275A1
公开(公告)日：2022-12-07
申请号：EP21213658.4
申请日：2014-03-17
摘要： The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing an antigen recognizing receptor and an inhibitory chimeric antigen receptor (iCAR). Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
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公开(公告)号：EP4031663A1
公开(公告)日：2022-07-27
申请号：EP20866833.5
申请日：2020-09-17
发明人： SADELAIN, Michel , ODAK, Ashlesha
IPC分类号： C12N15/09 , C12N15/90 , C12Q1/6809
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