公开(公告)号：EP3178494A1

公开(公告)日：2017-06-14

申请号：EP17152585.0

申请日：2010-07-09

申请人： Nanobiotix

发明人： LEVY, Laurent ,  POTTIER, Agnès ,  POUL, Laurence ,  MAGGIORELLA, Laurence

IPC分类号： A61K41/00 ,  A61P35/00

CPC分类号： A61K41/0038 ,  A61N5/10 ,  A61N2005/1098

摘要： The present application relates to activable nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cells, tissues or organs. It more particularly relates to nanoparticles which can generate a significantly efficient therapeutic effect, when exposed to ionizing radiations. The inventive nanoparticle is a metallic nanoparticle having, as the largest size, a size comprised between about 80 and 105 nm, the metal having preferably an atomic number (Z) of at least 25. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses.

摘要翻译： 本申请涉及可用于卫生部门，特别是人类健康的打乱，改变或破坏靶细胞，组织或器官的活性纳米粒子。 更具体地说，涉及当暴露于电离辐射时可产生显着有效的治疗效果的纳米颗粒。 本发明的纳米粒子是具有最大尺寸的金属纳米粒子，其尺寸在约80和105nm之间，所述金属优选具有至少25的原子序数（Z）。本发明还涉及药物组合物，其包含 如前所定义的纳米粒子以及它们的用途。

公开(公告)号：EP3150227A1

公开(公告)日：2017-04-05

申请号：EP16187263.5

申请日：2009-06-04

申请人： Nanobiotix

发明人： LEVY, Laurent ,  POTTIER, Agnès ,  ROUET, Annabelle ,  MARILL, Julie ,  DEVAUX, Corinne ,  GERMAIN, Matthieu

IPC分类号： A61K41/00 ,  A61P35/00 ,  B82Y5/00

CPC分类号： A61K41/0038 ,  B82Y5/00 ,  Y10S977/904

摘要： The present application relates to novel excitable particles which can be used in the health sector. It more particularly relates to particles which can generate electrons and/or high energy photon when excited by ionizing radiations such as X-Rays, γ-Rays, radioactive isotope and/or electron beams, and to the uses thereof in health, in particular in human health. The inventive particles are made of an inorganic material comprising oxygen, in particular an oxide, said material having an adequate density, and can be activated in vitro, ex vivo, or in vivo, by controllable external excitation, in order to disturb, alter or destroy target cells, tissues or organs. The invention also relates to methods for the production of said particles, and to pharmaceutical or medical device compositions containing same.

摘要翻译： 本申请涉及可用于健康部门的新型可兴奋颗粒。 更具体地说，涉及当通过电离辐射如X射线，3-射线，放射性同位素和/或电子束激发时能够产生电子和/或高能光子的颗粒，以及其在健康中的用途，特别是在 人类健康。 本发明的颗粒由包含氧，特别是氧化物的无机材料制成，所述材料具有足够的密度，并且可以通过可控的外部激发在体外，离体或体内活化，以便干扰，改变或 破坏靶细胞，组织或器官。 本发明还涉及生产所述颗粒的方法以及含有该颗粒的药物或医疗装置组合物。

公开(公告)号：EP2790682A1

公开(公告)日：2014-10-22

申请号：EP12806026.6

申请日：2012-12-17

申请人： Nanobiotix

发明人： POTTIER, Agnès ,  LEVY, Laurent ,  MEYRE, Marie-Edith

IPC分类号： A61K9/51 ,  A61K33/24 ,  A61P35/00

CPC分类号： A61K9/5115 ,  A61K9/0009 ,  A61K9/51 ,  A61K33/24 ,  A61K41/0038 ,  A61K41/0052 ,  A61K49/00 ,  A61K49/04 ,  A61K51/1244 ,  A61K2123/00 ,  A61N5/10

摘要： The present invention relates to novel nanoparticles which can be advantageously used in the health sector as diagnostic and/or therapeutic agents. Nanoparticles of the invention comprise a metallic material at least partly covered with an hafnium oxide material or embedded therein. When compared to existing products, these nanoparticles offer a remarkable benefit over risk ratio. Specifically, these nanoparticles potentiate the efficiency of known metallic nanoparticles. Indeed, they retain the metal intrinsic properties and are now in addition safely usable in a mammal, in particular in a human being. The invention also relates to methods for producing said nanoparticles, to compositions containing same, and to uses thereof.

公开(公告)号：EP2300054A2

公开(公告)日：2011-03-30

申请号：EP09757595.5

申请日：2009-06-04

申请人： Nanobiotix

发明人： LEVY, Laurent ,  POTTIER, Agnès ,  ROUET, Annabelle ,  MARILL, Julie ,  DEVAUX, Corinne ,  GERMAIN, Matthieu

IPC分类号： A61K41/00 ,  A61P35/00

CPC分类号： A61K41/0038 ,  B82Y5/00 ,  Y10S977/904

摘要： The present application relates to novel excitable particles which can be used in the health sector. It more particularly relates to particles which can generate electrons and/or high energy photon when excited by ionizing radiations such as X- Rays, γ-Rays, radioactive isotope and/or electron beams, and to the uses thereof in health, in particular in human health. The inventive particles are made of an inorganic material comprising oxygen, in particular an oxide, said material having an adequate density, and can be activated
in vitro ,
ex vivo , or
in vivo , by controllable external excitation, in order to disturb, alter or destroy target cells, tissues or organs. The invention also relates to methods for the production of said particles, and to pharmaceutical or medical device compositions containing same.