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    IRON OXIDE NANOPARTICLES COMPRISING TWO CENTERS OF ACTIVITIES OR FREE RADICAL CAPTURE/PRODUCTION FOR AN ENHANCED ACTIVITY
    3.
    发明公开
    IRON OXIDE NANOPARTICLES COMPRISING TWO CENTERS OF ACTIVITIES OR FREE RADICAL CAPTURE/PRODUCTION FOR AN ENHANCED ACTIVITY 审中-实审

    公开(公告)号：EP4371574A1

    公开(公告)日：2024-05-22

    申请号：EP23020496.8

    申请日：2023-11-08

    Applicant: Nanobacterie

    Inventor： Alphandery, Edouard ,  Chebbi, Imene

    IPC: A61K41/00 ,  A61P35/00

    CPC classification number: A61K41/0052 ,  A61P35/00 ,  A61K9/19 ,  A61K47/26 ,  A61K9/5094

    Abstract: The invention relates to a composition comprising at least one nanoparticle, wherein each nanoparticle preferentially comprises an iron oxide mineral core surrounded by a coating, wherein the composition further comprises a cryo-protectant or a compound that protects or maintains at least one property of the composition,
    wherein the core comprises a first center activity, CA1, and/or
    wherein the coating comprises a second center of activity, CA2,
    wherein CA1 and CA2 are preferentially selected in the group consisting of:
    A) a radio-sensitizer or amplifier of radiation, a radio-photosensitizer or amplifier of light radiation, an acoustic sensitizer or amplifier of acoustic radiation or wave, a sonosensitizer or amplificatory of acoustic wave, a particle radiation sensitizer or amplifier of particle radiation, where the particle comprises (or not) a mass, it is a thermal-sensitizer or amplifier of heat or cold or thermal treatment, an amplifier of the medical effect of a compound,
    and
    B) an attenuator of radiation, of light radiation, of acoustic radiation or wave, of particle radiation, where the particle comprises (or not) a mass, of heat or cold, of thermal treatment, and/or of the medical effect of a compound.

    IRON OXIDE NANOPARTICLES AND THEIR SYNTHESIS BY CONTROLLED OXIDATION
    7.
    发明公开
    IRON OXIDE NANOPARTICLES AND THEIR SYNTHESIS BY CONTROLLED OXIDATION 审中-公开

    公开(公告)号：EP3215131A4

    公开(公告)日：2018-07-04

    申请号：EP15856388

    申请日：2015-10-30

    Applicant: UNIV WASHINGTON

    Inventor： KRISHNAN KANNAN M ,  KHANDHAR AMIT PRAFUL ,  FERGUSON RICHARD M ,  KEMP SCOTT JEFFREY

    IPC: A61K9/16 ,  A61K9/00 ,  A61K9/51 ,  A61K41/00 ,  A61K49/18 ,  A61N1/40

    CPC classification number: A61K9/5115 ,  A61K9/0009 ,  A61K41/0052 ,  A61K49/1857 ,  A61K49/186 ,  A61N1/406

    Abstract: Disclosed herein are iron oxide nanoparticles having an iron (II) content in a metastable state that is intermediate the iron (II) content of wüstite and magnetite. The disclosed iron oxide nanoparticles exhibit unexpectedly beneficial magnetic properties (e.g., saturation magnetization) resulting from both the size of the nanoparticles and the iron (II) content. Accordingly, the iron oxide nanoparticles are attractive for magnetic imaging applications, such as magnetic particle imaging. Methods of forming the iron oxide nanoparticles are also provided, such methods including a controlled oxidation step wherein a small amount (e.g., 1%) of gaseous oxygen is exposed to wüstite nanoparticles for a defined period of time sufficient to partially oxidize the wüstite but prevent conversion entirely to magnetite. Finally, methods of using the iron oxide nanoparticles are also provided. Representative methods include magnetic particle imaging, magnetic resonance imaging, and hyperthermia.

    MAGNETIC NANOPARTICLES ASSOCIATED TO IMMUNOGENIC ENTITIES FOR DESTROYING PATHOLOGICAL CELLS IN AN INDIVIDUAL
    8.
    发明公开
    MAGNETIC NANOPARTICLES ASSOCIATED TO IMMUNOGENIC ENTITIES FOR DESTROYING PATHOLOGICAL CELLS IN AN INDIVIDUAL 无效
    与个体相关的磁性纳米粒子在个体中破坏病理细胞

    公开(公告)号：EP3311838A1

    公开(公告)日：2018-04-25

    申请号：EP16290202.7

    申请日：2016-10-21

    Applicant: Nanobacterie

    Inventor： The designation of the inventor has not yet been filed

    IPC: A61K41/00 ,  A61K49/18 ,  A61P35/00 ,  A61K33/26 ,  A61K47/69 ,  A61K35/74

    CPC classification number: A61K41/0052 ,  A61K47/6901 ,  A61K49/1896

    Abstract: This invention concerns a composition comprising at least one association of at least one magnetic nanoparticle and at least one substance, wherein the association is activated by radiation, for use in a treatment by radiation for destroying at least one pathological cell in an individual, comprising administering the composition at a body site of an individual and performing at least one type of activation of the association by radiation to activate magnetic nanoparticles without producing any temperature increase, whereby the pathological cell destruction occurs at the administration site and away from this site beyond the association diffusion region.

    Abstract translation: 本发明涉及包含至少一种磁性纳米颗粒和至少一种物质的缔合物的组合物，其中所述缔合物通过辐射活化，用于通过辐射进行治疗以破坏个体中的至少一种病理性细胞，所述方法包括给予 该组合物在个体的身体部位并通过辐射执行至少一种类型的关联活化以激活磁性纳米颗粒而不产生任何温度增加，由此病理性细胞破坏发生在给药部位并且远离该部位超过缔合 扩散区域。

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