公开(公告)号：EP2585445B1

公开(公告)日：2015-08-19

申请号：EP11727454.8

申请日：2011-06-24

申请人： Sandoz AG

发明人： HOTTER, Andreas ,  GRIESSER, Ulrich ,  ADAMER, Verena ,  LANGES, Christoph

IPC分类号： C07D277/56 ,  A61K31/425 ,  A61P19/06

CPC分类号： C07D277/56

公开(公告)号：EP2585445A2

公开(公告)日：2013-05-01

申请号：EP11727454.8

申请日：2011-06-24

申请人： Sandoz AG

发明人： HOTTER, Andreas ,  GRIESSER, Ulrich ,  ADAMER, Verena ,  LANGES, Christoph

IPC分类号： C07D277/56 ,  A61K31/425 ,  A61P19/06

CPC分类号： C07D277/56

摘要： The present invention relates to crystalline form I of Febuxostat as well as to pharmaceutical compositions comprising crystalline form I as an active pharmaceutical ingredient. Furthermore the present invention relates to a further polymorphic form of Febuxostat designated as form II and to a novel solvate of Febuxostat. The present invention also relates to methods of making crystalline form I, form II and the novel solvate of Febuxostat.

公开(公告)号：EP2376433A1

公开(公告)日：2011-10-19

申请号：EP09795765.8

申请日：2009-12-18

申请人： Sandoz AG

发明人： HOTTER, Andreas ,  WIESER, Josef ,  PICHLER, Arthur ,  DECRISTOFORO, Martin

IPC分类号： C07C237/26 ,  A61P31/00 ,  A61K31/65

CPC分类号： C07C237/26 ,  C07C2603/46

摘要： The present invention relates to crystalline form C of Tigecycline dihydrochloride and to methods for the preparation of the same. Furthermore the present invention relates to the use of crystalline form C of Tigecycline dihydrochloride as an intermediate for the preparation of an anti-infective medicament. Moreover the present invention relates to pharmaceutical compositions comprising crystalline form C of Tigecycline dihydrochloride in an effective amount and to the use of crystalline form C of Tigecycline dihydrochloride as an anti-infective medicament.

公开(公告)号：EP2318004A2

公开(公告)日：2011-05-11

申请号：EP09757457.8

申请日：2009-05-28

申请人： Sandoz AG

发明人： WIESER, Josef ,  PICHLER, Arthur ,  HOTTER, Andreas ,  GRIESSER, Ulrich ,  LANGES, Christoph ,  LASCHOBER, Christian

IPC分类号： A61K31/496 ,  A61P31/10

CPC分类号： A61K31/496

摘要： The present invention relates to a pharmaceutical composition comprising crystalline form Y of posaconazole. The pharmaceutical composition can be used to treat or prevent fungal infections.

公开(公告)号：EP2252579A2

公开(公告)日：2010-11-24

申请号：EP09703468.0

申请日：2009-01-19

申请人： Sandoz AG

发明人： DECRISTOFORO, Martin ,  WIESER, Josef ,  PICHLER, Arthur ,  HOTTER, Andreas

IPC分类号： C07C231/24 ,  C07C237/26

CPC分类号： C07C237/26 ,  C07B2200/13 ,  C07C231/24

摘要： The present invention relates to the new crystalline solid form Xl of Tigecycline and a process of preparing the same. Form Xl of Tigecycline is particularly suitable for the isolation of Tigecycline in the last step of the synthesis of Tigecycline. Further the present invention relates to a process of preparing amorphous Tigecycline by spray drying form Xl or another crystalline form of Tigecycline.

摘要翻译： 本发明涉及替加环素的新的结晶固体形式XI及其制备方法。 替加环素的形式X1特别适合于在替加环素合成的最后一步中分离替加环素。 进一步地，本发明涉及通过X形式或另一种替加环素结晶形式的喷雾干燥制备无定形替加环素的方法。