公开(公告)号：EP4402122A1

公开(公告)日：2024-07-24

申请号：EP22733028.9

申请日：2022-06-08

申请人： Zach System

发明人： FORCATO, Massimiliano ,  LEMERCIER, Aurélien ,  COQUEREL, Gérard ,  CARTIGNY, Yohann

IPC分类号： C07C231/24 ,  C07C237/06 ,  A61K31/165 ,  A61P25/16

CPC分类号： C07C231/24 ,  A61P25/16 ,  C07C237/06 ,  A61K31/165

公开(公告)号：EP4370499A1

公开(公告)日：2024-05-22

申请号：EP22748364.1

申请日：2022-07-14

申请人： Novo Nordisk A/S

发明人： VILHELMSEN, Thomas, Kvistgaard ,  DAMHOLT, Zacharias, Brimnes, Visby

IPC分类号： C07C231/24 ,  C07C235/60 ,  A61K47/00 ,  A61K9/20

CPC分类号： C07C235/60 ,  C07C231/24 ,  C07B2200/1320130101 ,  A61K9/1605 ,  A61K9/2004

公开(公告)号：EP2935204B1

公开(公告)日：2018-09-05

申请号：EP13864437.2

申请日：2013-11-19

申请人： GE Healthcare AS

发明人： CERVENKA, Jan ,  THANING, Mikkel ,  OLSSON, Andreas ,  GLOGARD, Christian

IPC分类号： C07C231/24 ,  C07C237/46 ,  A61K49/04

CPC分类号： C07C231/24 ,  A61K49/0438 ,  A61K49/0447 ,  C07C237/46

摘要： The present invention relates to a process for purification of iodinated X-ray contrast agents and in particular to purification of crude dimeric contrast agents, such as Iodixanol and Ioforminol. More particularly, the invention relates to purification of such X-ray contrast agents using membrane technology to remove monomeric impurities.

公开(公告)号：EP2870137B8

公开(公告)日：2018-07-18

申请号：EP13737357.7

申请日：2013-07-05

申请人： Kalvista Pharmaceuticals Limited

发明人： NORTHEN, Julian Scott ,  MYKYTIUK, John

IPC分类号： C07C237/22 ,  A61K31/166 ,  A61P29/00

CPC分类号： C07C237/22 ,  C07B2200/13 ,  C07C231/24

摘要： The invention provides new polymorphs of N—[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：EP3307720A1

公开(公告)日：2018-04-18

申请号：EP16731747.8

申请日：2016-06-10

申请人： Teva Pharmaceuticals International GmbH

发明人： LEKSIC, Edislav ,  SAMEC, Dijana, Skalec ,  SAHNIC, Damir ,  KISICEK, Dejan ,  HRKOVAC, Martina ,  TOPIC, Edi

IPC分类号： C07D257/04 ,  C07C233/47 ,  A61K31/225 ,  A61K31/41

CPC分类号： C07D257/04 ,  A61P9/04 ,  A61P9/12 ,  C07B2200/07 ,  C07B2200/13 ,  C07C231/24 ,  C07C233/47

摘要： Solid state forms of trisodium vaisartan:sacubitril, processes for their preparation, pharmaceutical compositions containing such solid state forms and treatment methods using the pharmaceutical compositions are described.

公开(公告)号：EP2997009A4

公开(公告)日：2017-01-18

申请号：EP14798293

申请日：2014-05-15

申请人： GLENMARK PHARMACEUTICALS LTD

发明人： BHIRUD SHEKHAR BHASKAR ,  KADAM SURESH MAHADEV ,  GAVHANE SACHIN BABAN ,  PAWASE SHAILESH SHRIRANG ,  DESHPANDE ANIKET ASHOKRAO ,  BHUJBAL ANIL SUBHASH

IPC分类号： C07C233/43 ,  C07C231/24

CPC分类号： C07C231/24 ,  C07B2200/07 ,  C07B2200/13 ,  C07C59/255 ,  C07C233/25

公开(公告)号：EP3031819A4

公开(公告)日：2017-01-04

申请号：EP14835250

申请日：2014-08-05

申请人： TSUGARU RINGO CERAM KK

发明人： SAKAI KENJI ,  TANAKA KIYOTO ,  KAKINAMI HIROKO ,  ITOKU KOU ,  KATAYAMA HISANOBU ,  YAMANO YUTAKA ,  ICHITA JUNJI ,  OSADA KYOICHI

IPC分类号： C07H15/10 ,  A61K8/68 ,  A61K8/73 ,  A61K8/97 ,  A61Q19/00 ,  A61Q19/02 ,  C07C231/24 ,  C07C233/20 ,  C07H1/08 ,  C08B37/00 ,  C08B37/06

CPC分类号： C08B37/0048 ,  A61K8/68 ,  A61K8/73 ,  A61K8/97 ,  A61K2800/10 ,  A61K2800/805 ,  A61Q19/00 ,  A61Q19/02 ,  C07C231/24 ,  C07C233/20 ,  C07H1/08 ,  C07H15/10 ,  C08B37/0003 ,  C08B37/0045

摘要： The object of the invention is to provide a method of extracting useful ingredients: ceramide and/or pectin from whole apples and/or apple juice residues. In this context, the invention also provides a method of regenerating and recycling spent ethanol. These objects are achievable by a method of extracting useful ingredients: ceramide and pectin from whole apples and/or apple juice residues and a method of recovering and regenerating, or recycling the ethanol used for extraction.

公开(公告)号：EP2807144A2

公开(公告)日：2014-12-03

申请号：EP13704179.4

申请日：2013-01-18

申请人： Robertet S.A.

发明人： CASAZZA, André ,  KORMANN, Karine

IPC分类号： C07C231/24 ,  C07C233/09

CPC分类号： A61K31/16 ,  A01N37/18 ,  A01N37/20 ,  A61K8/19 ,  A61K8/31 ,  A61K8/33 ,  A61K8/42 ,  A61K36/28 ,  A61K47/02 ,  A61K47/06 ,  A61K47/08 ,  A61Q19/08 ,  C07C231/24 ,  C07C233/09

摘要： The subject matter of the invention is a process for concentrating spilanthol contained in a composition, comprising the formation of an addition compound of spilanthol with a strong acid, then the hydrolysis of said addition compound. The process according to the invention makes it possible to easily obtain a composition which can comprise 100% of isolated actual spilanthol ((2E,6Z,8E)-N-(2-methylpropyl)deca-2,6,8-trienamide) or of a mixture of actual spilanthol with the isomers and/or homologues thereof that may accompany it.

公开(公告)号：EP2794553A1

公开(公告)日：2014-10-29

申请号：EP12790876.2

申请日：2012-11-20

申请人： Evonik Röhm GmbH

发明人： BRÖLL, Dirk ,  LAUX, Benedikt ,  MAUL, Christian ,  PETER, Patrick ,  ZIMMER, Claus

IPC分类号： C07C231/02 ,  C07C233/09 ,  C08F220/56

CPC分类号： C07C231/02 ,  C07C231/24 ,  C07C233/09

摘要： The invention relates to a process for preparing N-alkyl(meth)acrylamides by reaction of (meth)acrylic anhydride with corresponding alkylamines.

公开(公告)号：EP2504298A4

公开(公告)日：2013-05-01

申请号：EP09851564

申请日：2009-11-26

申请人： HOVIONE CHINA HOLDING LTD

发明人： HU ZHIQI ,  ZHANG HUOYING

IPC分类号： C07B63/00 ,  B01D15/08 ,  C07C231/24 ,  C07C237/46

CPC分类号： C07C231/24 ,  C07B63/00 ,  C07C237/46

摘要： An improved synthesis method for preparation of iodixanol, and a purification process through macroporous adsorption resin chromatographic column and recrystallization are provided. The synthesis method relates to dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (compound A) to prepare iodixanol, wherein excessive side reactions such as alkylation are effectively inhibited by controlling the pH of the reaction mixture with a boron-containing acidic substance or salts thereof such as boric acid. In this way, the conversion rate of compound A to iodixanol is 85-90%. The iodixanol crude product is purified by a macroporous adsorption resin chromatographic column, obtaining iodixanol product with recovery of 90-95% and purity of 96-98%. The iodixanol crude product is recrystallized in mixed solvent containing 2-methoxyethanol, obtaining iodixanol product with recovery of 90-95% and purity of greater than 99%.