公开(公告)号：EP0987022A1

公开(公告)日：2000-03-22

申请号：EP98912719.6

申请日：1998-04-08

申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI ,  TAIHO PHARMACEUTICAL CO., LTD.

发明人： ISHIZUKA, Masaaki ,  MAEDA, Kenji ,  TAKEUCHI, Tomio ,  SHIRAISHI, Tadayoshi ,  FUKUSHIMA, Masakazu

IPC分类号： A61K31/195

CPC分类号： A61K31/198 ,  Y10S514/885 ,  Y10S514/925 ,  Y10S514/926

摘要： Preventives and remedies for ulcerous colitis and/or Crohn's disease containing as the active ingredient conagenin or a pharmaceutically acceptable salt thereof and having prominent therapeutic effects and a high safety.

摘要翻译： 溃疡性结肠炎和/或克罗恩病的预防和治疗包含作为活性成分的连接蛋白或其药学上可接受的盐，具有突出的治疗效果和高安全性。

公开(公告)号：EP0627443B1

公开(公告)日：1997-03-26

申请号：EP93901539.2

申请日：1993-01-12

申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

发明人： TAKEUCHI, Tomio ,  UMEZAWA, Sumio ,  TSUCHIYA, Osamu ,  KAGEYAMA, Shunji ,  MIYAKE, Toshiaki ,  MATSUMOTO, Naoki ,  KOMINATO, Kaichiro ,  TANAKA, Hiroshi ,  YOSHIOKA, Takeo

IPC分类号： C07H17/08

CPC分类号： C07H17/08

摘要： A compound represented by general formula (1) which is useful for producing 3,4'-dideoxymycaminosyltylonolide useful as an antibacterial substance. In the said formula, A represents optionally protected carbonyl; B represents optionally protected formyl; R1 represents optionally protected hydroxy; R2 represents hydrogen or acyl; W represents hydrogen, hydroxy, lower alkanoyloxy or substituted sulfonyloxy; Y represents hydrogen, halogen, hydroxy or substituted sulfonyloxy; and symbol --- represents either a double or a single bond.

摘要翻译： 由通式（1）表示的化合物，其可用于制备可用作抗菌物质的3,4'-二脱氧碳霉糖基太乐内酯。 在所述式中，A表示任选被保护的羰基; B代表任选保护的甲酰基; R1代表任选被保护的羟基; R2代表氢或酰基; W代表氢，羟基，低级烷酰氧基或取代的磺酰氧基; Y代表氢，卤素，羟基或取代的磺酰氧基; 符号---代表双键或单键。

公开(公告)号：EP0423358A1

公开(公告)日：1991-04-24

申请号：EP90905686.3

申请日：1990-04-13

申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

发明人： TAKEUCHI, Tomio ,  AOYAGI, Takaaki ,  HAMADA, Masa ,  NAGANAWA, Hiroshi ,  MURAOKA, Yasuhiko ,  OGAWA, Keiji ,  NAGAI, Machiko,Syare Gakugeidai Kawabe 2-207 ,  TSUDA, Makoto, Nippon Kayaku Kabushiki Kaisha

IPC分类号： C07K5/08 ,  C12P21/02 ,  A61K37/02

CPC分类号： C07C229/22 ,  A61K38/00 ,  C07C271/22 ,  C07K5/0202 ,  C07K7/02

摘要： Postostatin, a new physiologically active substance represented by (I), can be isolated from the culture medium of an actinomycete belonging to the genus Streptomyces. It is a peptide compound having a new structure wherein a keto group is present in the peptide chain and it has a potent endopeptidase inhibitory activity. A postostatin-related compound having a keto group in the peptide chain can he synthesized chemically and this compound has a similar endopeptidase inhibitory activity.

摘要翻译： 由（I）表示的新的生理活性物质Postostatin可以从属于链霉菌属的放线菌的培养基中分离出来。 它是具有新结构的肽化合物，其中酮基存在于肽链中，并且其具有有效的内肽酶抑制活性。 肽链中具有酮基的抑制素相关化合物可以化学合成，该化合物具有相似的内肽酶抑制活性。