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103 条记录 (耗时 0.015 秒)

    HETEROMULTIMERS WITH REDUCED OR SILENCED EFFECTOR FUNCTION
    31.
    发明公开
    HETEROMULTIMERS WITH REDUCED OR SILENCED EFFECTOR FUNCTION 审中-公开
    具有减少或沉默效应的异源二聚体

    公开(公告)号：EP3004174A1

    公开(公告)日：2016-04-13

    申请号：EP14803370.7

    申请日：2014-05-30

    申请人： Zymeworks Inc.

    发明人： ESCOBAR-CABRERA, Eric

    IPC分类号： C07K16/46 ,  A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C12N15/13

    CPC分类号： C07K16/00 ,  C07K16/2887 ,  C07K16/32 ,  C07K2317/41 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/71 ,  C07K2317/92 ,  C07K2317/94

    摘要： Provided herein are heteromultimer constructs with reduced or silenced effector function. In an embodiment is provided a heteromultimer construct comprising an IgG Fc construct having a first and a second Fc polypeptide, each Fc polypeptide comprising a modified lower hinge region wherein: the modified lower hinge region of said first Fc polypeptide comprises at least one amino acid modification, the modified lower hinge region of said second Fc polypeptide comprises at least one amino acid modification which is different from at least one amino acid modification of said first Fc polypeptide, and the IgG Fc construct displays reduced binding to all Fcγ receptors and to C1q protein as compared to a corresponding parent IgG Fc construct. Also provided are methods of producing such heteromultimer constructs, and methods of reducing ADCC for an antibody construct by reducing effector function.

    SYSTEMS AND METHODS FOR MAKING TWO DIMENSIONAL GRAPHS OF COMPLEX MOLECULES
    33.
    发明公开
    SYSTEMS AND METHODS FOR MAKING TWO DIMENSIONAL GRAPHS OF COMPLEX MOLECULES 审中-公开
    系统和方法的复杂分子三维图形的生成

    公开(公告)号：EP2828779A4

    公开(公告)日：2015-12-02

    申请号：EP13763804

    申请日：2013-03-12

    申请人： ZYMEWORKS INC

    发明人： OHRN ANDERS ,  MACDONALD SCOTT PAUL

    IPC分类号： G06F19/00 ,  G06F19/26

    CPC分类号： G06F19/16 ,  G06F17/5009 ,  G06F19/26 ,  G06F19/708

    摘要： Systems and methods for two-dimensional visualization of a molecule, comprising the set of particles {p1, . . . , pN}, are provided. A set of N three-dimensional coordinates {x1, . . . , xN} is obtained, each xi in {x1, . . . , xN} describing a three-dimensional position for a corresponding particle pi in {p1, . . . , pN}. A cost function containing the error in a set of two-dimensional coordinates (c1, . . . , cN), where each Ci in (c1, . . . , cN) corresponds to a three-dimensional coordinate xi in {x1, . . . , xN}, is minimized until an exit condition is achieved. The minimization alters the values of (c1, . . . , cN). A set of physical properties SM is obtained, each Si,j in SM representing a physical property shared by a pair of particles (pi, pj) in {p1, . . . , pN}. Coordinates (c1, . . . , cN) are plotted as nodes of a two-dimensional graph after minimization. A plurality of edges for the graph is plotted. An edge in the plurality of edges connects a coordinate pair (ci, cj) in the graph that corresponds to a pair of particles (pi, pj) in {p1, . . . , pN}. A characteristic of the edge is determined by a physical property si,j in SM for the pair of particles (pi, pj).

    SYSTEMS AND METHODS FOR SAMPLING AND ANALYSIS OF POLYMER CONFORMATIONAL DYNAMICS
    35.
    发明公开
    SYSTEMS AND METHODS FOR SAMPLING AND ANALYSIS OF POLYMER CONFORMATIONAL DYNAMICS 审中-公开
    系统和方法进行取样和聚合物的构象动力学分析

    公开(公告)号：EP2885736A1

    公开(公告)日：2015-06-24

    申请号：EP13829560.5

    申请日：2013-08-16

    申请人： Zymeworks, Inc.

    发明人： DIXIT, Surjit B.

    IPC分类号： G06F19/16 ,  G06F19/20

    CPC分类号： G06F19/12 ,  G06F17/10 ,  G06F19/16 ,  G06F19/701

    摘要： Systems and methods for searching conformation space of a polymer to determine a three-dimensional conformation of the polymer that satisfies a performance metric is provided. The polymer comprises a plurality of domains and at least a first hinge. Initial three-dimensional coordinates of the polymer are altered by pivoting the first domain with respect to the second domain about the first hinge thereby obtaining an altered set of three-dimensional coordinates for the polymer. In this altering, atoms within the first domain are held fixed with respect to each other and atoms within the second domain are also held fixed with respect to each other. The altered set of coordinates is scored against a performance metric. Additional instances of the altering and scoring are performed, if necessary, until the altered set of three-dimensional coordinates satisfy the performance metric.

    DENSITY BASED CLUSTERING FOR MULTIDIMENSIONAL DATA
    37.
    发明公开
    DENSITY BASED CLUSTERING FOR MULTIDIMENSIONAL DATA 有权
    对多维数据基于密度聚类

    公开(公告)号：EP2504776A1

    公开(公告)日：2012-10-03

    申请号：EP10832469.0

    申请日：2010-11-23

    申请人： Zymeworks Inc.

    发明人： RODINGER, Tomas ,  LARIO, Paula I.

    IPC分类号： G06F17/30 ,  G06F19/24 ,  G06F19/00

    CPC分类号： G06F16/285 ,  G06F16/3331 ,  G06F16/9535 ,  G16B20/00 ,  G16B40/00

    摘要： A new density based clustering method for clustering data points in multidimensional space is described. Each point has a neighborhood consisting of all points that are within a preset cutoff radius or distance. Each point is assigned a density measure based on the number of points in its neighborhood. Any point that has a higher density than any of its neighboring points is the center of a cluster and is assigned a unique cluster ID. Every other point follows a path through the graph of neighboring points such that density is increasing as fast as possible until a cluster center is reached. The algorithm's performance is demonstrated on a one-dimensional, two-dimensional, and 18-dimensional dataset.