摘要:
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/II2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a yeloproliferative neoplasia.
摘要:
Ablegerkasten (10), mit einem aus einem Boden (20) und einer Mehrzahl von sich senkrecht vom Boden (20) erstreckenden Wänden (30) gebildeten Kasten und einem in einem bodennahen Abschnitt einer Wand (30) angeordneten Flugloch (40), wobei das Flugloch (40) durch eine in einem Teilbereich des Bodens (20) und einer Wand (30) gebildete L-förmige, einen Freiraum (40) zwischen Boden (20) und Wand (30) eröffnende Ausnehmung gebildet ist, und ein mit dem Ablegerkasten (10) lösbar zu verbindendes, zwei L-förmig miteinander verbundene Schenkel (50a, 50b) aufweisendes Element (50) vorgesehen ist, wobei das Element (50) das Flugloch (40) zum Transport des Ablegerkastens (10) in einer ersten Position die Ausnehmung mit beiden Schenkeln (50a, 50b) einnehmend verschließt und das Flugloch (40) in einer zweiten Position, in der ein Schenkel (50a) von der Ausnehmung aufgenommen und der andere Schenkel (50b) sich unter Bildung eines vor dem Flugloch (40) angeordneten Flugbretts (50b) vom Ablegerkasten erstreckt, freigibt.
摘要:
The invention relates to a cage (1) able to accommodate a queen bee when she needs to be temporarily separated from the nursery of the hive, comprising at least one wall having at least one inner portion constructed so as to perfectly reproduce the hexagonal cells (11) of a honeycomb.
摘要:
An insect holder for holding an insect of a particular type, e.g. a forager honey bee, comprises a housing with a chamber adapted to receive an insect of the particular type, an inlet to the chamber through which an insect of the particular type can pass to enter the chamber, a head opening to the chamber adapted to permit the head of an insect of the particular type in the chamber to pass therethrough to the exterior of the housing while retaining the insect in the housing, and retaining means for retaining an insect of the particular type in the chamber with the head of the insect protruding through the head opening to the exterior of the housing, such that the insect is unable to turn around in the chamber. In use, an insect of the particular type enters the chamber via the inlet, and is then retained in the holder by the retaining means. The insect is retained in the chamber, with its head protruding through the head opening of the chamber. The insect is constrained to be unable to turn around in the chamber or withdraw its head into the chamber, so the head of the insect must remain outside the chamber. The insect is thus held in the holder with the head visible, so that observations can be made on the insect head, e.g. monitoring proboscis movement in known manner. When observations are finished, the retaining means can be removed or deactivated so that the insect is able to leave the chamber, with the insect unharmed and undamaged.
摘要:
The invention features a method of inducing amyloid plaque deposition in a mammal by infusing into the brain of the mammal an amyloid peptide at a basic pH, a nontransgenic animal model for Alzheimer's disease, and methods of identifying compounds to treat Alzheimer's disease.
摘要:
A cage-type device (10) for trapping, storing, transporting and releasing a queen bee (50), possible with one or more worker bees (58). The cage comprises two slidingly attachable members (12,14) which constitute bottom and roof members and also side-walls, in which there are provided entry (16) and exit ports (18,22) for the queen bee and for worker bees, which can be opened or closed, as required, by changing the relative position of the two slideable members (12,14). There is also provided a comparatively large opening, preferably in the floor section, for scooping up the queen bee, which can also be closed by a sliding motion of the two members (12,14). According to one embodiment, a compartment (23) for a supply of bee food is provided. According to another embodiment, a slot of predetermined shape can be provided in one of the walls through which a movable member (103) can be inserted, which makes possible to move the queen bee (50) to a desired location in the cage (10).