COPOLYMER, ANTITHROMBOTIC COATING AGENT USING SAME AND MEDICAL DEVICE

    公开(公告)号:EP3424964A1

    公开(公告)日:2019-01-09

    申请号:EP17759472.8

    申请日:2017-01-24

    IPC分类号: C08F216/18 A61L33/06

    摘要: The present invention has an object to find a biocompatible material that has excellent film formation properties and resistance to water dissolution, and can be easily applied on various bases as a coating, while having excellent antithrombotic properties, and to provide an antithrombotic coating agent and an antithrombotic coating film produced by using the biocompatible material, and a medical device provided with the antithrombotic coating film. Means for achieving the object are a copolymer containing at least one repeating unit (A) represented by formula (1) (wherein, n represents an integer of 2 to 10 and R 1 represents a methyl group or an ethyl group), and at least one repeating unit (B) represented by formula (2) (wherein R 2 represents an aliphatic hydrocarbon group); an antithrombotic coating agent containing the copolymer and an organic solvent; an antithrombotic coating film formed of the copolymer; and a medical device provided with the coating film.

    Process for the preparation of a copolymer of maleic anhydride and an alkyl vinyl ether, copolymers of maleic anhydride and an alkyl vinyl ether and an apparatus
    33.
    发明公开
    Process for the preparation of a copolymer of maleic anhydride and an alkyl vinyl ether, copolymers of maleic anhydride and an alkyl vinyl ether and an apparatus 审中-公开
    一种用于马来酸酐和烷基乙烯基醚,马来酸酐和烷基乙烯基醚和装置的共聚物的共聚物的制备方法

    公开(公告)号:EP1331232A1

    公开(公告)日:2003-07-30

    申请号:EP02075333.1

    申请日:2002-01-28

    申请人: DSM N.V.

    摘要: Process for the preparation of a copolymer of maleic anhydride and an alkyl vinyl ether, comprising the steps of supplying maleic anhydride and the alkyl vinyl ether and an initiator, together forming a feed flow, through an inlet to a reactor wherein maleic anhydride and the alkyl vinyl ether react to a copolymer of maleic anhydride an alkyl vinyl ether thereby forming a reaction mixture with the maleic anhydride, the alkyl vinyl ether and the initiator characterized in that the process is a continuous process and the reactor is a loop reactor wherein the reaction mixture is internally circulated, whereby this reaction mixture arrives at the inlet before the maleic anhydride and alkyl vinyl ether have completely reacted while a remainder of initiator is still present.
    The invention further relates to copolymer of maleic anhydride and alkyl vinyl ether, including hydrolyzed or alcoholized copolymers, characterized in that a molecular weight distribution, expressed as Mw/Mn, is less than 2.
    The invention also relates to an apparatus for conducting the process of the invention.

    摘要翻译: 过程用于制备烷基乙烯基醚的马来酸酐和共聚物的方法,包括在入口到反应器中worin马来酸酐和烷基供给马来酸酐和烷基乙烯基醚的引发剂,并一起形成进料流,通过如下步骤 乙烯基醚反应,马来酸酐的共聚物与烷基乙烯基醚,从而形成与马来酸酐,烷基乙烯基醚和特征做了方法是连续过程,所述反应器是环管反应器的引发剂的反应混合物worin将反应混合物 在内部循环,由此该反应混合物到达入口之前的马来酸酐和烷基乙烯基醚已经完全呼叫反应,同时一个引发剂的剩余部分是静静地存在。 本发明还涉及到马来酸酐和烷基乙烯基醚,包括水解或醇解共聚物,在做了分子量分布,表示为Mw / Mn为特点的共聚物,是小于2。本发明因此涉及到对设备进行该处理 的本发明。

    MALEIC ANHYDRIDE/ALKYL VINYL ETHER POLYMERIZATION PROCESS
    35.
    发明授权
    MALEIC ANHYDRIDE/ALKYL VINYL ETHER POLYMERIZATION PROCESS 失效
    马来酸酐/烷基乙烯基醚POLYMERISIERUNGVERFAHREN。

    公开(公告)号:EP0542758B1

    公开(公告)日:1995-11-29

    申请号:EP91912312.5

    申请日:1991-07-11

    CPC分类号: C08F216/18 C08F222/06

    摘要: What is described herein is a process for making a copolymer of high specific viscosity by polymerisation of maleic anhydride and a C1-C4 alkyl vinyl ether monomer. The invention involves polymerizing said monomers to form a slurry of said copolymer in excess alkyl vinyl ether as solvent and toluene or an aliphatic organic compound as cosolvent, and is characterized by the steps of: (a) precharging a reactor with C1-C4 alkyl vinyl ether as solvent at a reaction temperature, (b) feeding a mixture of maleic anhydride and a C1-C4 alkyl vinyl ether in substantially stoichiometric amounts, preferably with a slight excess of the alkyl vinyl ether, and at a selected rate, into said precharged reactor, and (c) simultaneously feeding a predetermined mixture of toluene or an aliphatic organic compound and a polymerization initiator continuously over substantially the entire period of polymerization.

    A process for the preparation of an alkyl vinyl ether/maleic anhydride copolymer
    36.
    发明公开
    A process for the preparation of an alkyl vinyl ether/maleic anhydride copolymer 失效
    Verfahren zur Herstellung eines烷基乙烯基醚/马来酸酐聚合物。

    公开(公告)号:EP0522465A1

    公开(公告)日:1993-01-13

    申请号:EP92111312.2

    申请日:1992-07-03

    IPC分类号: C08F222/06 C08F216/18

    CPC分类号: C08F216/18 C08F222/06

    摘要: An improved process for the preparation of an alkyl vinyl ether/maleic anhydride copolymer in which copolymerization is carried out in an admixture of an ester and an hydrocarbon.
    The alkyl vinyl ether/maleic anhydride copolymer obtained by this process does not contain any harmful aromatic solvent such as benzene, etc. In addition, the alkyl vinyl ether/maleic anhydride copolymer has a higher apparent bulk density than can be obtained in prior processes.

    摘要翻译: 用于制备烷基乙烯基醚/马来酸酐共聚物的改进方法,其中以酯和烃的混合物进行共聚。 通过该方法获得的烷基乙烯基醚/马来酸酐共聚物不含任何有害的芳族溶剂如苯等。此外,烷基乙烯基醚/马来酸酐共聚物的表观堆积密度高于现有方法中可获得的表观堆积密度。