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公开(公告)号：EP2890705B1
公开(公告)日：2016-04-13
申请号：EP14755340.8
申请日：2014-07-23
CPC分类号： C07J43/003 , C07J31/006
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32.发明授权Process and intermediates for the production of 7-substituted antiestrogens 有权方法和中间体的7- substitiuerter抗雌激素剂的制备
公开(公告)号：EP1918295B1
公开(公告)日：2016-04-06
申请号：EP08150796.4
申请日：2001-10-09
申请人： AstraZeneca AB
发明人： Stevenson, Robert , Kerr, Fraser, Witton , Lane, Anthony, Raymond , Brazier, Eve, Joanne , Hogan, Philip, John , Laffan, David, Dermot, Patrick
IPC分类号： C07J31/00
CPC分类号： C07J31/006 , C07J31/00 , Y02P20/55
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33.发明公开A NOVEL CHOLESTEROL METABOLITE, 5-CHOLESTEN, 3beta-25-DIOL, DISULFATE (25HCDS) FOR THERAPY OF METABOLIC DISORDERS, HYPERLIPIDEMIA, DIABETES, FATTY LIVER DISEASES AND ATHEROSCLEROSIS 有权NOVEL胆固醇代谢物5-胆甾烯，烷-3β-25二醇，二硫酸盐（25HCDS）代谢紊乱，高血脂症，糖尿病，脂肪肝和动脉粥样硬化治疗
公开(公告)号：EP2836502A4
公开(公告)日：2015-08-19
申请号：EP13775974
申请日：2013-03-15
发明人： REN SHUNLIN
CPC分类号： C07J31/006 , A61J1/14 , C07J9/00 , C07J31/003
摘要： 5-cholesten-3, 25-diol, disulfate (25HCDS) has been found to be an authentic PPAR ³ agonist and LXR antagonist, and is used for the therapy of lipid disorders and inflammatory diseases, including without limitation fatty liver, inflammatory bowel, and atherosclerotic diseases.
摘要翻译： 5-胆甾烯，激动剂3.beta;，25-二醇，过二硫酸盐（25HCDS）已被证实是可靠PPAR和LXR拮抗剂，并用于脂质病症和炎性疾病的治疗，包括但不限于脂肪肝，炎性肠病， 和动脉粥样疾病。
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34.发明授权6.ALPHA.,9.ALPHA.-DIFLUORO-17.ALPHA.-(2-FURANYLCARBOXYL)OXY-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXO-ANDROST-1,4-DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER AS AN ANTI-INFLAMMATORY AGENT 有权6.ALPHA，9.ALPHA.二氟17.ALPHA .-（2- FURANYLCARBOXYL）OXY-11.BETA.羟基16.ALPHA.甲基-3-氧代雄甾-1,4-二烯 17硫代羧酸S-氟甲基酯作为抗炎药
公开(公告)号：EP1305329B2
公开(公告)日：2015-03-18
申请号：EP01953272.0
申请日：2001-08-03
申请人： GLAXO GROUP LIMITED
CPC分类号： C07J31/006
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35.发明授权METHOD FOR MONOFLUOROMETHYLATION OF ORGANIC SUBSTRATES TO PREPARE BIOLOGICALLY ACTIVE ORGANIC COMPOUNDS 有权方法MONOFLUORMETHYLATION有机基板来制造生物活性有机化合物
公开(公告)号：EP2576583B1
公开(公告)日：2015-01-14
申请号：EP11727730.1
申请日：2011-06-01
IPC分类号： C07J31/00
CPC分类号： C07J31/006
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36.发明公开3,3 DISUBSTITUTED 19-NOR PREGNANE COMPOUNDS, COMPOSITIONS, AND USES THEREOF 审中-公开3,3-二取代19-NOR孕化合物的组合物，使用体和
公开(公告)号：EP2766380A1
公开(公告)日：2014-08-20
申请号：EP12781534.8
申请日：2012-10-12
发明人： UPASANI, Ravindra, B. , ASKEW, Benny, C. , HARRISON, Boyd, L. , DISTEFANO, Peter, Scott , SALITURO, Francesco, G. , ROBICHAUD, Albert, J.
IPC分类号： C07J5/00 , C07J7/00 , C07J31/00 , C07J43/00 , A61K31/57 , A61K31/573 , A61K31/58 , A61P25/00
CPC分类号： C07J43/003 , C07J5/0015 , C07J7/002 , C07J7/008 , C07J7/0085 , C07J9/005 , C07J31/006
摘要： Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I) and (III): where R1, R2, R3, R3′, R4, R6a, R6a, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (TBI), stress, and epilepsy.
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37.发明授权ANIONIC PREGNANE COMPOUNDS, METHOD FOR THEIR PRODUCING AND USE OF THEM 有权阴离子PREGNANVERBINDUNGEN，制造方法及其应用
公开(公告)号：EP2313424B1
公开(公告)日：2014-04-23
申请号：EP09775815.5
申请日：2009-07-09
申请人： Ústav organické chemie a biochemie Akademie ved Ceské republiky, v.v.i. , Fyziologicky ústav Akademie ved Ceské republiky, v.v.i.
发明人： STASTNA, Eva , CHODOUNSKA, Hana , POUZAR, Vladimir , KAPRAS, Vojtech , CAIS, Ondrich , VYKLICKY, Ladislav , KOHOUT, Ladislav
CPC分类号： C07J41/0077 , C07J7/002 , C07J31/006
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公开(公告)号：EP2332960A3
公开(公告)日：2013-08-28
申请号：EP10194457.7
申请日：2010-12-10
发明人： Aqad, Emad , Li, Mingqi , Mattia, Joseph
IPC分类号： C07J9/00 , C07C381/12 , C07J31/00 , G03F7/004 , G03F7/038
CPC分类号： G03F7/0045 , C07C381/12 , C07J31/006 , G03F7/0046 , G03F7/0382
摘要： New photoacid generator compounds ("PAGs") are provided that comprise a cholate moiety and photoresist compositions that comprise such PAG compounds.
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39.发明公开METHODS AND COMPOUNDS FOR THE PREPARATION OF MONOFLUOROMETHYLATED BIOLOGICALLY ACTIVE ORGANIC COMPOUNDS 有权方法和化合物生产MONOFLUORMETHYLIERTER生物活性有机化合物
公开(公告)号：EP2576584A1
公开(公告)日：2013-04-10
申请号：EP11727731.9
申请日：2011-06-01
IPC分类号： C07J31/00
CPC分类号： C07J75/00 , C07J3/005 , C07J17/00 , C07J31/006
摘要： The present invention describes processes for the preparation of, monofluoromethylated organic biologically active compounds, such as Fluticasone Propionate and Fluticasone Furoate, in the presence of fluorodecarboxylating reagents such as XeF
2 and BrF
3 .-
公开(公告)号：EP2188299A4
公开(公告)日：2012-12-12
申请号：EP08829680
申请日：2008-09-08
申请人： GENAERA CORP
发明人： MCLANE MICHAEL , RUIZ-WHITE INEZ , WOLFE HENRY
CPC分类号： C07J41/0005 , C07J5/00 , C07J31/006 , C07J41/0011 , C07J41/005 , C07J41/0055 , C07J43/003
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